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Since last couple of decades, C-2-formyl glycals have sustained interest in carbohydrate chemistry as they afford valuable chiral building blocks for many biological / pharmaceutical / industrial based important molecules. Basically, C-2-formyl glycals are a class of carbohydrates incorporating an α,β-unsaturated aldehyde. Therefore in many organic reactions, the C-2-formyl-glycals molecule could therefore serve as an α,β-unsaturated aldehyde core. In this review, we have compiled a literature survey on the synthesis of C-2-formyl-glycals and further their importance for the synthesis of many medicinal, supramolecular, biological, organic as well as material chemistry-based molecules.

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