C-Glycopyranosyl aldehydes: emerging chiral synthons in organic synthesis

Abstract

Herein, we have summarized the vast array of synthetic processes that have been developed for the synthesis of C-glycopyranosyl aldehydes and diverse C-glycoconjugates derived from them by covering the literature reported during 1979 to 2023.

Vinyl Esters and Vinyl Sulfonates as Green Alternatives to Vinyl Bromide for the Synthesis of Monosubstituted Alkenes via Transition-Metal-Catalyzed Reactions

“…The Sonogashira reaction Cross-coupling reactions are also useful for the introduction of simple fragmentsnamely, the vinyl group. Traditionally, dehydrohalogenation [77], the Wittig reaction [78][79][80][81][82], or the Peterson olefination [83,84] were commonly used to introduce the vinyl group, although the discovery of cross-coupling reactions has expanded the available vinylation methods. In principle, vinylation can be performed via the reaction of metalated ethylene with an electrophilic reagent in the presence of a catalytic amount of a transition metal complex (Scheme 3).…”