Glycated Hemoglobin and Red Blood Cell Indices in Non-diabetic Pregnant Women

Abass, Awad-Elkareem; Musa, Imad R.; Rayis, Duria A.; Gasim, Gasim I.

doi:10.4081/cp.2017.999

Cited by 13 publications

(9 citation statements)

References 36 publications

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“…These ndings suggest that up-regulation of metallothionein gene might be involved in insulin resistance through the modulation of insulin action in type 2 diabetes. Consistently, a previous study showed a signi cant positive correlation between glycohemoglobin (HbA1c) value with Hb, HCT, and MCHC in non-diabetic pregnant women [30].…”

Section: Discussionsupporting

confidence: 84%

Association of Metallothionein 2A rs10636 with low mean cor-puscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese

Chen

Pan

et al. 2022

Preprint

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Human metallothionein-2A (MT2A) protein participates in metal homeostasis, detoxification, oxidative stress reduction, and immune defense. It decreases heavy metal ions and reactive oxygen species (ROS) during injury of cells and tissues. The single nucleotide poly-morphisms at the MT2A gene have been associated in various human diseases including cancer.; The current study aimed to elucidate associations between MT2A genotypes with the clinical, biochemical, and molecular characteristics that potentially related to lowered MT2A ex-pression. One hundred and twenty-one healthy Taiwanese subjects were enrolled from Changhua Show-Chwan Memorial Hospital. Clinical, biochemical and molecular characteristics including the frequent minor allele SNPs, rs28366003 and rs10636, within the MT2A gene were determined.; The genotype distribution of MT2A rs10636 fits the Hardy-Weinberg equilibrium. The significant associations with gradually decline of mean corpuscular volume (MCV) and mean corpuscular hemoglobin (MCH) were identified with MT2A rs10636 using analysis of variance (ANOVA) with Tukey’s analysis as a post hoc test. We further validated the correlations between the expressions of genes in erythropoiesis, cholesterol synthesis, platelet synthesis, insulin with MT2A using the web-based Gene Expression Profiling Interactive Analysis (GEPIA) databases. The results revealed that hypoxia-inducible factor 1α (HIF-1α), erythropoietin (EPO), lipoprotein lipase (LPL), and lecithin-cholesterol acyltransferase (LCAT) mRNA ex-pression are significantly correlated with MT2A mRNA expression.; In conclusion, these results suggested that genetic variations of MT2A rs10636 might be an important risk factor for erythropoiesis in the Taiwanese general population.

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Section: Discussionsupporting

confidence: 84%

Association of Metallothionein 2A rs10636 with low mean cor-puscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese

Chen

Pan

et al. 2022

Preprint

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“…Intriguingly, data from non-diabetic pregnant women have suggested that there is a positive correlation between HbA1c and haemoglobin, haematocrit and MCHC. 36 Because HbA1c is only tested in seroconverted children in TEDDY, future studies should determine whether this association occurs before or after seroconversion.…”

Section: Discussionmentioning

confidence: 99%

“…This information together with our results of the inverse association between MCV and MCH with HbA1c represents a process that takes place already during an autoimmune attack on the beta cells and may remain until after diagnosis of type 1 diabetes. Intriguingly, data from non‐diabetic pregnant women have suggested that there is a positive correlation between HbA1c and haemoglobin, haematocrit and MCHC 36 …”

Section: Discussionmentioning

confidence: 99%

Complete blood counts with red blood cell determinants associate with reduced beta‐cell function in seroconverted Swedish TEDDY children

Salami

Tamura

Larsson

et al. 2021

Endocrino Diabet & Metabol

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Objectives: To investigate whether changes in complete blood count (CBC) in islet autoantibody positive children with increased genetic risk for type 1 diabetes are associated with oral glucose tolerance tests (OGTT) and HbA1c over time. Methods:The Environmental Determinants of Diabetes in the Young (TEDDY) study follows children with increased risk for type 1 diabetes in the United States, Germany, Sweden and Finland. In the current study, 89 Swedish TEDDY children (median age 8.8 years) positive for one or multiple islet autoantibodies were followed up to 5 (median 2.3) years for CBC, OGTT and HbA1c. A statistical mixed effect model was used to investigate the association between CBC and OGTT or HbA1c.Results: HbA1c over time increased by the number of autoantibodies (p < .001).Reduction in mean corpuscular haemoglobin (MCH) and mean cell volume (MCV) was both associated with an increase in HbA1c (p < .001). A reduction in red blood cell (RBC) counts (p = .003), haemoglobin (p = .002) and haematocrit (p = .006) levels was associated with increased fasting glucose. Increased red blood cells, haemoglobin, haematocrit and MCH but decreased levels of red blood cell distribution widths (RDW) were all associated with increased fasting insulin. Conclusions:The decrease in RBC indices with increasing HbA1c and the decrease in RBC and its parameters with increasing fasting glucose in seroconverted children may reflect an insidious deterioration in glucose metabolism associated with islet beta-cell autoimmunity. K E Y W O R D Sautoimmunity, glucose metabolism, HbA1c, red blood cells, type 1 diabetesThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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“…19,20 Also, this finding is contradictory with similar study done by Li et al, among pregnant women and concluded that there was no significant difference of hemogram changes. [21][22] Also, our result showed no clinically significant (≥ 0.05) in RBCs, MCH and MCHC among those women. This finding supported that during pregnancy, the total blood volume increases by about 1.5 L, mainly to supply the demands of the new vascular bed and to compensate for blood loss occurring at delivery.…”

Section: Discussionmentioning

confidence: 47%

Changes in blood and urine parameters among pregnant women during third trimester

Osman

Eltom

Ismail

et al. 2019

Int J Reprod Contracept Obstet Gynecol

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Background: During pregnancy, the pregnant lady undergoes significant anatomical and physiological changes in order to nurture and accommodate the developing fetus. These changes begin after conception and affect every organ system in the body.Methods: The study was carried out in the United Arab Emirates - Ajman (Thumbay Hospital) during the period of (March - Jun) in the year of 2018 to estimate HbA1c% levels, hematological blood parameters and urine culture in healthy pregnant women during 3rd trimester. The study was conducted on (108) healthy pregnant women during3rd trimester. Urine culture was performed to detect the growth of bacteria after the culture, gram stain was done to differentiate the bacteria followed by biochemical test to detect the type of bacteria.Results: A total 26 (79%) of patients had normal HbA1c% result while 7(21%) had elevated HbA1c% result. The results of HbA1c% in last trimester mean±SD (range) HbA1c% (n=33) were 5.5±0.52% (111.5±14.8 mg/dL). Also, our results showed strong positive correlation between HbA1% with estimated Average blood glucose (r=0.78, P value=0.00), and weak positive correlation between HbA1 with age (years) (r=0.2, P value=0.02). Bacterial culture showed that two positive results of stenotrophomonas maltophilia was isolated, three cases of Staphylococcus aureus was isolated and three cases of staphylococcus saprophyticus. Hematological profile showed a clinically significant (≤ 0.05) in Hb mean 11.47, P value 0.001, HCT mean, 33.9 P value 0.001 and MCV mean 73.7 value 0.001. No clinically significant (≥ 0.05) in RBCs mean 3.93, P value 0.010, MCH mean 27.3 P value 0.061 and MCHC mean 30.9 P value 0.134.Conclusions: Our study conclude that estimation of HbA1c%, hematological blood parameters and urine culture level in last trimester will be helpful in diagnosis, monitoring and predicting fetal distress.

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Glycated Hemoglobin and Red Blood Cell Indices in Non-diabetic Pregnant Women

Cited by 13 publications

References 36 publications

Association of Metallothionein 2A rs10636 with low mean cor-puscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese

Association of Metallothionein 2A rs10636 with low mean cor-puscular volume (MCV), low mean corpuscular haemoglobin (MCH) in healthy Taiwanese

Complete blood counts with red blood cell determinants associate with reduced beta‐cell function in seroconverted Swedish TEDDY children

Changes in blood and urine parameters among pregnant women during third trimester

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