Background/Aim: Pre-eclampsia (PE) and eclampsia are major obstetric problem in developing countries and remains an important cause of maternal mortality worldwide. The study aimed to evaluate/compare the platelet count and platelet indices in pre-eclampsia and normal pregnancies Methods: This prospective case control study was conducted in Khartoum state at Omdurman Maternity Hospital, during the period from March to June 2016. Pregnant women (N/87) with 28 weeks' gestation or more who attended at antenatal care unit or admitted into the Department of Obstetrics and Gynecology, were selected as population of the study. Among them 37 patients with either mild or sever PE, 50 normal pregnancies as controls were enrolled. EDTA-venous blood sample was collected from each patient and control for platelet count and platelet indices measurement by automated blood cells counter . Results: In the present study the mean platelet counts was 236.16±82.33, 261.34 ±62.69 X10 9 /L in patients and controls respectively. The mean MPV was 10.15±1. 10 and 9.48±0.87/fl, whereas mean PDW was 13.37±2.84, 12.15±2.35 /fl as well as mean P-LCR% was 26.71±7.87, 22.32±6.52% in patients and controls respectively. The present study found that MPV(P; 0.02), PDW (P; 0.03) and P-LCR (P; 0.05) of PE group was significantly higher than normal group. The platelets count (P; 0.1) and plateletcrit (PCT%) (P; 0.64) were lower in PE group but didn't show significant variation. Conclusion: Platelet indices of MPV, PDW and P-LCR increases in PE in comparison to normal pregnancy Key.

Seropositivity for H. pylori IgG was associated with LBW.

Hemoglobin A1c (HbA1c) is affected by the red blood cell (RBC) lifespan. The association of HbA1c with RBC indices in pregnant women is not widely investigated. In this study, we investigated the association between HbA1c and Hb/RBCs count and RBCs indices; specifically, Hb/RBCs count and indices in non- diabetic pregnant women. Across-sectional study was carried- out at the antenatal care of Saad Abu Elela Hospital, Khartoum, Sudan. Obstetrics history was gathered using questionnaire and body mass index was calculated. Fasting blood sugar, at one hour, at two hours post prandial and HbA1c were investigated. Complete blood count parameters of RBCs count was performed, including, hematocrit, Hb, RBCs indices of MCV, MCH, and MCHC. One hundred twenty three women were enrolled. The mean age of the participants was 28±5.6 years and a mean body mass index was 27.65±6.8 k/m². There was significant positive correlation between HbA1c and Hb (r=0.174, P=0.037), Hct (r=0.174, P=0.037), and MCHC (r=0.180, P=0.031). A negative correlation between HbA1c and the platelet index PDW (r= –0.198, P=0.017) was documented. The rest of the other factors showed no correlation with HbA1c. In linear regression analysis, HbA1c correlated positively with Hb (P=0.044) and Hct (P=0.047). The present study shows a significant positive correlation between HbA1c value with Hb, Hct, and MCHC. No significant correlation between HbA1c and other RBCs parameters was observed.

BackgroundThe pathogenesis of malaria during pregnancy is not completely understood. There are few published data on complement activation and malaria during pregnancy. This study aimed to investigate complement activation and malaria during pregnancy, and their association with hemoglobin and birth weight.MethodsA cross-sectional study was conducted at Medani, Sudan. Soluble terminal complement complex (TCC) levels were measured using ELISA in maternal and cord blood samples from 126 parturient women.ResultsThere were no Plasmodium falciparum-positive blood films from maternal peripheral blood, the placenta, or cord blood samples. Three (2.4%) and 22 (17.5%) of the placentas showed chronic and previous infection with histopathological examination, respectively, while 101 (80.2%) of them had no malaria infection. The mean [SD] of the maternal (22.4 [6.1] vs. 26.5 [3.5] ng/ml, P < 0.001) and cord blood (24.5 [4.5] vs. 26.8 [4.4] ng/ml, P = 0.024) TCC levels were significantly lower in cases of placental malaria infection (n = 25) than in those without placental malaria infection (n = 101). Linear regression showed that placental malaria infection was significantly associated with birth weight (−0.353 g, P = 0.013), but there were no associations between maternal and cord TCC levels and maternal hemoglobin, or between TCC levels and birth weight.ConclusionMaternal and cord blood TCC levels are lower in women with placental malaria infection than in those without placental malaria infection.Virtual SlideThe virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9600054761463915

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