Glucocorticoids mediate macrophage dysfunction in protein calorie malnutrition*

Hill, A. D. K.; Naama, Hassan A.; Gallagher, H. J.; Shou, Jian; Calvano, Steven E.; Daly, J.M.

doi:10.1016/s0039-6060(05)80315-0

Cited by 28 publications

(15 citation statements)

References 19 publications

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“…Corticosteroids are known to suppress the phagocytic capacity of both macrophages and polymorphonuclear cells [13]. Moreover, Hill et al [14] succeeded in preventing the stimulated superoxide and IL-6 production by peritoneal macrophages of malnourished mice blocking the stress corticosterone response by adrenalectomy.…”

Section: Discussionmentioning

confidence: 99%

Effect of Three Days Starvation on the Phagocytic Activity of Rat Peritoneal Macrophages

Salman

Bergman²,

Bessler³

et al. 1998

Acta Haematol

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To examine the effect of starvation on the phagocytic activity of rat peritoneal macrophages, 8 animals were kept for 3 days on water supply only. The cells showed an increased capacity for superoxide anion production and a marked decrease in their ability to engulf latex particles. The corticosterone level of the fasting animals was markedly increased, an observation suggesting that the alteration of macrophage function could be hormonally mediated. The findings in the present study indicate that the decreased phagocytic capacity of peritoneal macrophages following starvation may be one of the factors responsible for the increased susceptibility to infections in malnourished individuals.

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Section: Discussionmentioning

confidence: 99%

Effect of Three Days Starvation on the Phagocytic Activity of Rat Peritoneal Macrophages

Salman

Bergman²,

Bessler³

et al. 1998

Acta Haematol

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“…Glucocorticoids may control inflammation by inhibiting many aspects of the inflammatory process via an increase in the transcription of anti-inflammatory genes and a decrease in the transcription of inflammatory genes [147,149,150] .…”

Section: Leptin and Glucocorticoids In Malnutritionmentioning

confidence: 99%

Modulation of Lung Allergic Inflammation and Malnutrition

Landgraf¹,

Landgraf

Carvalho³

et al. 2008

Neuroimmunomodulation

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Nutritional deficiency is commonly associated with a significantly impaired immune response, particularly in relation to cell-mediated immunity, the complement system, cytokine production and phagocyte function. However, there are few data on the consequences of nutritional deficiency in allergic diseases of the lung. In fact, malnutrition is the most common cause of immunodeficiency worldwide. Several studies have indicated that the incidence of alterations in lung functions can be associated with birth weight, specifically with maternal malnutrition, but data linking intrauterine undernutrition with allergic diseases of the lung are lacking. The purpose of this review is to associate malnutrition, including intrauterine malnutrition, with the establishment of immune responses and the development of lung allergic inflammation.

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“…Previous studies have identified the glucocorticoid response as an important mediator of the effects of PEM in a murine model; however, blockade of the glucocorticoid response only partially reverses PEMrelated host impairment. 1 Other factors, therefore, must contribute to the multifold effects of protein deprivation. Given that leptin is a regulator of food intake and body mass, and has hormone-like activity in the HPA, 15,16 we hypothesized that serum leptin levels are altered in PEM and that the glucocorticoid response may play a role in regulating these levels.…”

Section: As Recorded Inmentioning

confidence: 99%

“…1 In hospitalized patients, the persistent weight loss of PEM is associated with altered immune functions, leading to increased morbidity and mortality that is manifested by delayed wound healing and increased infectious complications. 1 Because hospitalized patients frequently have important comorbidities such as age, injury, and use of immunosuppressive agents, it is difficult to differentiate the independent effect of PEM in this group. 2,3 Animal models of PEM are useful to dissect the physiologic dysfunction associated with PEM. Work in this laboratory has previously shown in a murine model that a protein-free diet for 7 days significantly increases serum corticosterone, the major stress-induced murine glucocorticoid.…”

mentioning

confidence: 99%

“…2,3 Animal models of PEM are useful to dissect the physiologic dysfunction associated with PEM. Work in this laboratory has previously shown in a murine model that a protein-free diet for 7 days significantly increases serum corticosterone, the major stress-induced murine glucocorticoid. 1 This model is characterized by an approximate 15% weight loss in PEM mice and significant immune impairment, whereas the control mice do not show these impairments. Moreover, other studies have reported that rats fed a protein-deficient diet have reduced food intake, but this remains a poorly understood phenomenon.…”

mentioning

confidence: 99%

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