Serum leptin levels in acute protein deprivation

Stapleton, P.C.; Barden, CB; McCarter,; Mackrell, PJ; Freeman, TA; Ha, Naama; Jm, Daly

doi:10.1177/0148607103027002132

Cited by 4 publications

(3 citation statements)

References 28 publications

(36 reference statements)

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“…Their ability to engulf pathogens and to produce cytokines and ROIs is impaired [51–54]. However, the suggestion that malnutrition suppresses macrophage functions due to elevated glucocorticoid levels was not supported by a recent study [55]. Further experiments are required to identify the mechanisms connecting PEM and immunosuppression.…”

Section: Malnutrition Leptin and Immunitymentioning

confidence: 99%

Malnutrition and Infection: Complex Mechanisms and Global Impacts

2007

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Section: Malnutrition Leptin and Immunitymentioning

confidence: 99%

Malnutrition and Infection: Complex Mechanisms and Global Impacts

2007

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“…Interestingly, however, we demonstrated that serum leptin was positively associated with food intake in these infected animals. Most studies have shown reduced serum leptin in PEM (Haluzik et al 1999; Soliman et al 2000; Palacio et al 2002) with the exception of Stapleton et al (2003). Our data in infected mice, if anything, suggest higher leptin in PD mice than in PS mice.…”

Section: Discussionmentioning

confidence: 99%

Re-feeding rapidly restores protection againstHeligmosomoides bakeri(Nematoda) in protein-deficient mice

Koski

Wykes

et al. 2007

Parasitology

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This study determined whether the timing of re-feeding of protein-deficient mice restored functional protection against the gastrointestinal nematode, Heligmosomoides bakeri. Balb/c mice were fed a 3% protein-deficient (PD) diet and then transferred to 24% protein-sufficient (PS) diet either on the day of primary infection, 10 days after the primary infection, on the day of challenge infection, or 7 days after the challenge infection. Control mice were fed either the PD or PS diet. Onset of challenge, but not primary, infection caused short-term body weight loss, anorexia and reduced feed efficiency. Weight gain was delayed in mice when re-feeding commenced on the day of challenge infection; alkaline phosphatase (ALP) was also elevated in these mice on day 28 post-challenge. In contrast, other re-feeding groups attained similar body weights to PS mice within 4 days and had similar ALP at day 28. Serum leptin was higher in PD than PS mice and positively associated with food intake. As expected, worm survival was prolonged in mice fed the PD diet. However, egg production and worm burdens were similar in all re-feeding groups to the PS mice, indicating that protein re-feeding during either the primary or challenge infection rapidly restored normal parasite clearance.

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“…BMI berkorelasi secara signifikan dengan leptin. Stapleton (2003) menemukan bahwa pada hewan coba yang diberi diet tanpa protein (0% kasein) mengalami peningkatan serum leptin yang signifikan dibandingkan kontrol yang diberi diet 24% kasein [21,22].…”

Section: Pendahuluanunclassified

Korelasi Pemberian Diet Rendah Protein Terhadap Status Protein, Imunitas, Hemoglobin, dan Nafsu Makan Tikus Wistar Jantan (The Correlation of Low Protein Diet Administration on Status of Protein, Immunity, Hemoglobin, and Appetite of Male Wistar Rats Rattus norvegicus)

Anggraeny

Dianovita²,

Putri³

et al. 2016

IJHN

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AbstrakKwashiorkor merupakan salah satu bentuk kekurangan energi protein (KEP) yang disebabkan oleh kurangnya asupan protein. Kwashiorkor sering dihubungkan dengan adanya penyakit infeksi dan anemia. Tingkat kematian akibat kwashiorkor dapat mencapai 10-30 persen. Penanganan kasus kwashiorkor melalui intervensi bahan makanan harus dilakukan secara hatihati karena terjadi penurunan imunitas. Perlu dilakukan uji kelayakan bahan makanan terlebih dulu pada hewan coba; tetapi karena di Indonesia belum ada diet standar untuk membuat model hewan coba kwashiorkor maka penelitian ini merupakan studi pendahuluan untuk membuat hewan coba kondisi kwashiorkor dengan mengetahui pengaruh pemberian diet rendah protein terhadap beberapa variabel yang merupakan indikator kondisi kwashiorkor. Metode yang digunakan adalah dengan pemberian diet rendah protein dengan berbagai konsentrasi (0%, 2%, 4%, dan 18% sebagai diet cukup protein) selama 2 dan 4 minggu. Albumin, IgG, leukosit, hemoglobin, dan leptin serta perubahan berat badan diukur sebagai indikator kondisi kwashiorkor. Analisis statistik menggunakan One-way ANOVA serta dilanjutkan dengan uji korelasi Pearson menggunakan SPSS 16. Regresi linear digunakan untuk mengetahui tren dari perubahan tiap nilai variabel dengan berbagai pemberian kadar protein. Jumlah protein berkorelasi dengan kadar albumin (2 minggu dan 4 minggu) dan dengan kadar IgG (2 minggu) serta ada beda kadar albumin antara kelompok perlakuan 4 minggu (p=0,007, p<0,05). Masih terlalu dini untuk menggunakan diet rendah protein dalam penelitian ini sebagai standar diet untuk membuat tikus model dengan kondisi defisiensi protein yang kronik seperti pada kwashiorkor namun diet rendah protein (0%) selama 4 minggu dalam penelitian ini dapat digunakan untuk mengetahui efektivitas pemberian intervensi gizi tertentu terhadap perubahan kadar albumin.

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Serum leptin levels in acute protein deprivation

Abstract: Leptin may be an important mediator of weight loss and decreased food intake in PEM. Elevated serum leptin in PEM may be secondary to elevated serum corticosterone, with other factors inherent in the host response to protein restriction also contributing to elevated serum leptin.

Cited by 4 publications

References 28 publications

Malnutrition and Infection: Complex Mechanisms and Global Impacts

Malnutrition and Infection: Complex Mechanisms and Global Impacts

Re-feeding rapidly restores protection againstHeligmosomoides bakeri(Nematoda) in protein-deficient mice

Korelasi Pemberian Diet Rendah Protein Terhadap Status Protein, Imunitas, Hemoglobin, dan Nafsu Makan Tikus Wistar Jantan (The Correlation of Low Protein Diet Administration on Status of Protein, Immunity, Hemoglobin, and Appetite of Male Wistar Rats Rattus norvegicus)

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