Modulation of Lung Allergic Inflammation and Malnutrition

Abstract

Nutritional deficiency is commonly associated with a significantly impaired immune response, particularly in relation to cell-mediated immunity, the complement system, cytokine production and phagocyte function. However, there are few data on the consequences of nutritional deficiency in allergic diseases of the lung. In fact, malnutrition is the most common cause of immunodeficiency worldwide. Several studies have indicated that the incidence of alterations in lung functions can be associated with birth weight, specifically with maternal malnutrition, but data linking intrauterine undernutrition with allergic diseases of the lung are lacking. The purpose of this review is to associate malnutrition, including intrauterine malnutrition, with the establishment of immune responses and the development of lung allergic inflammation.

Mast cells and eosinophils: the two key effector cells in allergic inflammation

“…The proximity of mast cells and eosinophils in allergic inflammation and the fact that they can stimulate each other even in the absence of an exogenously added activator [30][31][32] has generated several hypotheses on a crosstalk between the two cells. In fact, some in vitro studies have suggested possible pathways of soluble cross-talk between these cells [33][34][35][36][37][38].…”

Geoepidemiology of COPD and idiopathic pulmonary fibrosis

“…Malnutrition is associated with a poor COPD prognosis and may be associated with the development of pulmonary allergic inflammation [25]. Zinc and nitrogen monoxide protect against autoimmunity, cancer, infection, and allergies under Th1 conditions [26].…”

Influência do exercício sobre a resposta imunológica de ratos desnutridos.

“…Foi também relatada depressão da resposta imune cutânea em testes de hipersensibilidade tardia (CHANDRA, 1997;LANDGRAF et al, 2008), redução do número absoluto de linfócitos T no sangue periférico e diminuição da resposta proliferativa desta população de linfócitos em cultura (SCHAIBLE e KAUFFMAN, 2007). Além disso, a proporção de linfócitos T auxiliadores/indutores (CD4 + ) apresentou-se reduzida, com pouca alteração na subpopulação de células T supressoras/citotóxicas CD8 + (CHANDRA, 1997;CHATRAW et al, 2008).…”