Glucantime-loaded electrospun core-shell nanofibers composed of poly(ethylene oxide)/gelatin-poly(vinyl alcohol)/chitosan as dressing for cutaneous leishmaniasis

Electrospun Nanofibers for Wound Dressing and Tissue Engineering Applications

“…The observed results of the study demonstrated the potency of developed nanofibers as competitive candidates for their use in effective wound dressings [95]. Likewise, accountable progresses intensely being made in this aspect, especially in the very recent time several studies reported the use of bovine serum albumin/polyacrylonitrile biohybrid nanofibers [96], poly(ethylene oxide)/gelatin-poly(vinyl alcohol)/chitosan nanofibers [97], PCL/gelatin nanofibers [98], PVA/ hyaluronic acid/L-arginine nanofibers [99] and cellulose acetate/poly(lactic acid) nanofibrous mats [100] for effective wound dressing applications. Therefore, the electrospinning approach has been undoubtedly advanced the wound dressing application for effective wound care management.…”

Fabrication of Hybrid Nanofibers from Biopolymers and Poly (Vinyl Alcohol)/Poly (ε-Caprolactone) for Wound Dressing Applications

“…The mechanical characterization of nanofibers demonstrated ultimate tensile strength of 7.11 ± 0.38 MPa, Young’s modulus of 253.41 ± 12.13 MPa, and elongation at a break of 3.02 ± 0.11%, indicating good mechanical performance for wound dressing application. The in vitro drug release profile at the physiological conditions demonstrated approximately 84% of the encapsulated drug was released from the nanofibers in the initial 2 h and then after 5 h. Almost all the encapsulated drug was released [ 101 ]. The anti-Leishmania analysis using the flow cytometry method showed that the pristine nanofibers possessed almost antileishmanial efficacy (4.4 ± 0.3% cell death), which was similar to the untreated leishmanial parasites (0.7 ± 0.0% death) as the negative reference.…”

“…However, glucantime-encapsulated hybrid nanofibers displayed leishmanicidal activity in a dose-dependent mode and destroyed 73.8 ± 2.3%, and 79.6 ± 2.2% of parasites with 4 and 6-cm 2 of glucantime-incorporated nanofiber, respectively, with no toxic effects on the human fibroblast cells. These results demonstrated gelatin–PVA–chitosan nanofibers encapsulated with glucantime as the potential scaffolds for treating Leishmania wounds [ 101 ].…”

A bio‐inspired gelatin‐based pH‐ and thermal‐sensitive magnetic hydrogel for in vitro chemo/hyperthermia treatment of breast cancer cells

“…2,[10][11][12] The intense interest in the case of Gel for pharmaceutical applications rises form its relative low cost, excellent biodegradability and biocompatibility, antimicrobial and antioxidant activities, as well as chemical modification opportunity owing to its available reactive groups (e.g., carboxyl, amine, and hydroxyl). 13,14 However, Gel has poor mechanical strength, high solubility, and somewhat high degradation rate that can be modified through various chemical or physical techniques. In this regard, the chemical modification of Gel using stimuli-responsive synthetic polymers and its crosslinking can be considered as powerful approaches to the development of "smart" DDSs based on this natural polypeptide.…”

“…It isolated from animal collagen through partial acidic (type A), alkaline (type B), or enzymatic hydrolysis that can be utilize in pharmaceutical technology as hard or soft capsules 2,10–12 . The intense interest in the case of Gel for pharmaceutical applications rises form its relative low cost, excellent biodegradability and biocompatibility, antimicrobial and antioxidant activities, as well as chemical modification opportunity owing to its available reactive groups (e.g., carboxyl, amine, and hydroxyl) 13,14 . However, Gel has poor mechanical strength, high solubility, and somewhat high degradation rate that can be modified through various chemical or physical techniques.…”