GH overexpression decreases spermatic parameters and reproductive success in two-years-old transgenic zebrafish males

Figueiredo, Márcio Azevedo; Fernandes, Raíssa V.; Studzinski, Ana Lupe Motta; Rosa, Carlos Eduardo da; Corcini, Carine Dahl; Varela, Antônio Sérgio; Marins, Luís Fernando

doi:10.1016/j.anireprosci.2013.03.012

Cited by 18 publications

(15 citation statements)

References 36 publications

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“…This demonstrates the balance between the networks regulating somatic growth and reproduction Analysis of the global gene expression patterns in the zebrafish pituitary during the juvenile and sex maturation stages revealed that luteinizing hormone β (lhb) is the only pituitary hormone transcript to exhibit a significant change in expression between 45 and 90 dpf [48]. A decrease in spermatic parameters and reproductive success has been observed in GH overexpressing zebrafish males [124]. Additionally, GH overexpression in grass carp (Ctenopharyngodon idellus) females is associated with delayed gonadal development, and is accompanied by elevated GH and decreased LH levels in serum [103].…”

Section: Interaction Between the Endocrine Regulations On Somatic Gromentioning

confidence: 98%

Neuroendocrine regulation of somatic growth in fishes

Dai

Zhang

Zhuo

et al. 2015

Sci. China Life Sci.

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Growth is a polygenic trait that is under the influence of multiple physiological pathways regulating energy metabolism and muscle growth. Among the possible growth-regulating pathways in vertebrates, components of the somatotropic axis are thought to have the greatest influence. There is growing body of literature focusing on the somatotropic axis and its role regulating growth in fish. This includes research into growth hormone, upstream hypothalamic hormones, insulin-like growth factors, and downstream signaling molecules. Many of these signals have both somatic effects stimulating the growth of tissues and metabolic effects that play a role in nutrient metabolism. Signals of other endocrine axes exhibit profound effects on the function of the somatotropic axis in vivo. In this review we highlight recent advances in our understanding of the teleost fish endocrine somatotropic axis, including emerging research using genetic modified models. These studies have revealed new aspects and challenges associated with regulation of the important steps of somatic growth. somatic growth, endocrine regulation, fish Citation:

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Section: Interaction Between the Endocrine Regulations On Somatic Gromentioning

confidence: 98%

Neuroendocrine regulation of somatic growth in fishes

Dai

Zhang

Zhuo

et al. 2015

Sci. China Life Sci.

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“…Growth hormone ( GH ), growth hormone receptor ( GHR ), and insulin-like growth factor-1 ( IGF-1 ) are candidate genes for evaluating pig growth traits (2). GH is a polypeptide produced by the adenohypophysis, and is a main factor that promotes somatic growth in vertebrates (3). GH is also involved in morphology, physiology, metabolism, immunology, reproduction, and behavior (4), and it promotes skeletal system growth and facilitates amino acid incorporation during protein synthesis (5).…”

Section: Introductionmentioning

confidence: 99%

Single-nucleotide polymorphism analysis of GH, GHR, and IGF-1 genes in minipigs

Tian

Yue

et al. 2014

Braz J Med Biol Res

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Tibetan (TB) and Bama (BM) miniature pigs are two popular pig breeds that are used as experimental animals in China due to their small body size. Here, we analyzed single-nucleotide polymorphisms (SNPs) in gene fragments that are closely related to growth traits [growth hormone (GH), growth hormone receptor (GHR), and insulin-like growth factor (IGF)-1)] in these pig breeds and a large white (LW) control pig breed. On the basis of the analysis of 100 BMs, 108 TBs, and 50 LWs, the polymorphic distribution levels of GH, GHR, and IGF-1 were significantly different among these three pig breeds. According to correlation analyses between SNPs and five growth traits - body weight (BW), body length (BL), withers height (WH), chest circumference (CC), and abdomen circumference (AC) - three SNP loci in BMs and four SNP loci in TBs significantly affected growth traits. Three SNP sites in BMs and four SNP sites in TBs significantly affected growth traits. SNPs located in the GH gene fragment significantly affected BL and CC at locus 12 and BL at locus 45 in BMs, and also BW, WH, CC, and AC at locus 45 and WH and CC at locus 93 in TBs. One SNP at locus 85 in the BM GHR gene fragment significantly affected all growth traits. All indices were significantly reduced with a mixture of alleles at locus 85. These results provide more information regarding the genetic background of these minipig species and indicate useful selection markers for pig breeding programs.

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“…Recent research indicates that GH interacts with the HPG axis at the hypothalamus, pituitary, and gonadal levels. Besides effects on the HPG axis, GH exerts its impact by affecting metabolism and energy allocation (Bartke et al, 1999;Figueiredo et al, 2013). Because the neuroendocrine system is a complex system that might involve many different gene regulatory networks, analysis of large amounts of omics data will be needed to infer those networks and connections so that we can better understand the involvement of GH on reproduction.…”

Section: Interaction Of Gh and Reproductionmentioning

confidence: 99%