Endocrinology: Advances through omics and related technologies

García-Reyero, Natàlia; Tingaud‐Sequeira, Angèle; Cao, Mengxi; Zhang, Zhu; Perkins, Edward J.; Hu, Wei

doi:10.1016/j.ygcen.2014.03.042

Cited by 12 publications

(9 citation statements)

References 171 publications

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“…We linked these changes with altered biological endpoints caused by exposure to EE2. Transcriptomics approaches have been used to identify specific modes of action associated with biological responses to chemical exposures (Garcia-Reyero et al 2014; Levi et al 2009; Miller et al 2012). Identifying genes and pathways that may result in specific phenotypic alterations in organisms provides valuable insight into the mechanism of action of EE2.…”

Section: Introductionmentioning

confidence: 99%

Dietary exposure of 17-alpha ethinylestradiol modulates physiological endpoints and gene signaling pathways in female largemouth bass (Micropterus salmoides)

et al. 2014

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17alpha-ethinylestradiol (EE2), used for birth control in humans, is a potent estrogen that is found in wastewater at low concentrations (ng/L). EE2 has the ability to interfere with the endocrine system of fish, affecting reproduction which can result in population level effects. The objective of this study was to determine if dietary exposure to EE2 would alter gene expression patterns and key pathways in the liver and ovary and whether these could be associated with reproductive endpoints in female largemouth bass during egg development. Female LMB received 70 ng EE2/g feed (feed administered at 1% of body weight) for 60 days. EE2 dietary exposure significantly reduced plasma vitellogenin concentrations by 70%. Hepatosomatic and gonadosomatic indices were also decreased with EE2 feeding by 38.5% and 40%, respectively. Transcriptomic profiling revealed that there were more changes in steady state mRNA levels in the liver compared to the ovary. Genes associated with reproduction were differentially expressed such as vitellogenin in the liver and aromatase in the gonad. In addition, a set of genes related with oxidative stress (e.g. glutathione reductase and glutathione peroxidase) were identified as altered in the liver and genes associated with the immune system (e.g. complement component 1, and macrophage-inducible C-type lectin) were altered in the gonad. In a follow-up study with 0.2 ng EE2/g feed for 60 days, similar phenotypic and gene expression changes were observed that support these findings with the higher concentrations. This study provides new insights into how dietary exposure to EE2 interferes with endocrine signaling pathways in female LMB during a critical period of reproductive oogenesis.

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Section: Introductionmentioning

confidence: 99%

Dietary exposure of 17-alpha ethinylestradiol modulates physiological endpoints and gene signaling pathways in female largemouth bass (Micropterus salmoides)

et al. 2014

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“…While this trend has gained traction in the biomedical sciences community, it has recently surged in the environmental monitoring and comparative endocrinology arena (Garcia-Reyero et al, 2014; Jungnickel et al, 2014; Scanlan et al, 2015; Schneider and Orchard, 2011). In this study, we created a new ‘eicosanomic’ strategy for the quantitation of the eicosanoid milieu in non-traditional species, models, and/or matrices.…”

Section: Discussionmentioning

confidence: 99%

Alterations in eicosanoid composition during embryonic development in the chorioallantoic membrane of the American alligator (Alligator mississippiensis) and domestic chicken (Gallus gallus)

Cantu

Bowden

Scott

et al. 2016

General and Comparative Endocrinology

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Eicosanoids are signaling lipids known to regulate several physiological processes in the mammalian placenta, including the initiation of parturition. Though all amniotes construct similar extraembryonic membranes during development, the composition and function of eicosanoids in extraembryonic membranes of oviparous reptiles is largely unknown. The majority of effort placed in eicosanoid investigations is typically targeted toward defining the role of specific compounds in disease etiology; however, comprehensive characterization of several pathways in eicosanoid synthesis during development is also needed to better understand the complex role of these lipids in comparative species. To this end, we have examined the chorioallantoic membrane (CAM) of the American alligator (Alligator mississippiensis) and domestic chicken (Gallus gallus) during development. Previously, our lab has demonstrated that the CAM of several oviparous species shared conserved steroidogenic activity, a feature originally attributed to mammalian amniotes. To further explore this, we have developed a liquid chromatography/tandem mass spectrometry method that is used here to quantify multiple eicosanoids in the CAM of two oviparous species at different stages of development. We identified 18 eicosanoids in the alligator CAM; the cyclooxygenase (COX) pathway showed the largest increase from early development to later development in the alligator CAM. Similarly, the chicken CAM had an increase in COX products and COX activity, which supports the LC-MS/MS analyses. Jointly, our findings indicate that the CAM tissue of an oviparous species is capable of eicosanoid synthesis, which expands our knowledge of placental evolution and introduces the possibility of future comparative models of placental function.

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“…Protein-protein interaction [31] Hypertension [32] Renal diseases [33,34] Tuberculosis [35] Cardiovascular homeostasis [36] Endocrine processes [37] Atherosclerosis [38] Chronic pulmonary obstruction [39] Cancer [40][41][42][43][44] Virus infection [45] Arthritis [46] Doping [47] Process/Disease Protein-protein interaction [31] Hypertension [32] Renal diseases [33,34] Tuberculosis [35] Cardiovascular homeostasis [36] Endocrine processes [37] Atherosclerosis [38] Chronic pulmonary obstruction [39] Cancer [40][41][42][43][44] Virus infection [45] Arthritis [46] Doping [47] Citation: Plaza Table 1). This technical-analytical boom, among others, led to the development of the called "human genome project" for instance (Https://www.genome.gov/10001772/allabout-the--human-genome-project-hgp/).…”

Section: Process/diseasementioning

confidence: 99%

Impact of the “Omics Sciences” in Medicine: New Era for Integrative Medicine

Martínez-Espinosa¹

2017

J Clin Microbiol Biochem Technol

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Background and objective: This work collects and analyses information about the evolution of medical practice during the last centuries. The main aim is to summarise new insights on "omics sciences" and their impact in medicine. Methods: Use of appropriate keywords, use of different engines of research information and the subsequent bibliometric analysis of the information. Results: The impact of the "omics sciences" in the early diagnosis of diseases is highly signifi cant. Consequently, the implementation of "omics sciences" in medical practises contribute to the improvement of the monitoring and treatment of several diseases (particularly those based on molecular disorders). Conclusions: Advances in the techniques of biotechnology, analytical chemistry, biochemistry, and molecular biology are the source of the emergence and rapid evolution of a new omics era. This omic era has allowed the introduction and development of a medicine much more optimised and personalised, which is considered by many professionals as the medicine of the 21st century. This work is timely due to the high international interest for personalised medicine, healthcare and quick medical diagnosis.

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Endocrinology: Advances through omics and related technologies

Cited by 12 publications

References 171 publications

Dietary exposure of 17-alpha ethinylestradiol modulates physiological endpoints and gene signaling pathways in female largemouth bass (Micropterus salmoides)

Dietary exposure of 17-alpha ethinylestradiol modulates physiological endpoints and gene signaling pathways in female largemouth bass (Micropterus salmoides)

Alterations in eicosanoid composition during embryonic development in the chorioallantoic membrane of the American alligator (Alligator mississippiensis) and domestic chicken (Gallus gallus)

Impact of the “Omics Sciences” in Medicine: New Era for Integrative Medicine

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