Genetic polymorphisms associated with type 2 diabetes in the Arab world: A systematic review and meta-analysis

Abuhendi, Najat; Qush, Abeer; Naji, Fozieh; Abunada, Hanan; Buainain, Reeham Al; Shi, Zumin; Zayed, Hatem

doi:10.1016/j.diabres.2019.03.037

Cited by 24 publications

(10 citation statements)

References 72 publications

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“…Genome wide association studies have yielded several single nucleotide polymorphisms that appear to be associated with the development of diabetes. A recent meta-analysis reported that, for people in the MENA area, 71 single nucleotide polymorphisms in 32 genes increased the risk of T2D by 24%-69%[ 7 ]. There was a strong association with single nucleotide polymorphisms in the TCF7L2 (in 9 countries) and CDKAL1 genes (in 4 countries), in addition to a variety of other loci, including ADIPOQ , FTO , MC4R .…”

Section: Risk Factorsmentioning

confidence: 99%

“…Despite the heterogeneity within the MENA countries in terms of culture, income, population size, and sociopolitical stability[ 5 , 6 ], multiple common predisposing factors for diabetes have been implicated, including aging of the population, the change in lifestyle with reduction in physical activity, and increased consumption of calories and unhealthy food items, which have led to a rise in the prevalence of overweightness and obesity[ 2 ]. Genetic and epigenetic factors may also be contributing elements[ 7 ]; in a region that has a high rate of consanguinity[ 8 ], multiple gene loci that predispose to diabetes have been identified in the Eastern Mediterranean Region (EMR) population[ 9 ]. In addition to diabetes, prediabetes has been identified in a sizable proportion of the MENA population[ 2 ], out of whom a majority is expected to progress to diabetes over time[ 10 ].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Epidemiology of type 2 diabetes in the Middle East and North Africa: Challenges and call for action

El‐Kebbi¹,

Bidikian²,

Hneiny³

et al. 2021

WJD

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Type 2 diabetes continues to be a serious and highly prevalent public health problem worldwide. In 2019, the highest prevalence of diabetes in the world at 12.2%, with its associated morbidity and mortality, was found in the Middle East and North Africa region. In addition to a genetic predisposition in its population, evidence suggests that obesity, physical inactivity, urbanization, and poor nutritional habits have contributed to the high prevalence of diabetes and prediabetes in the region. These risk factors have also led to an earlier onset of type 2 diabetes among children and adolescents, negatively affecting the productive years of the youth and their quality of life. Furthermore, efforts to control the rising prevalence of diabetes and its complications have been challenged and complicated by the political instability and armed conflict in some countries of the region and the recent coronavirus disease 2019. Broad strategies, coupled with targeted interventions at the regional, national, and community levels are needed to address and curb the spread of this public health crisis.

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Section: Risk Factorsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Epidemiology of type 2 diabetes in the Middle East and North Africa: Challenges and call for action

El‐Kebbi¹,

Bidikian²,

Hneiny³

et al. 2021

WJD

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show abstract

“…SNP rs34872471, rs7901695, and rs35198068 reported to have a strong association with T2DM in Saudi Arabia, Danish, Iceland, America, and Malaysia. (Ghassibe-Sabbagh et al, 2014) (Cook & Morris, 2016) (Abuhendi et al, 2019)(Grant et al, 2006) (Huzaimi, 2009. The three SNP's also expected to be associated in Indonesia so it can be used as T2DM marker.…”

Section: Results and Discuss Tcf7l2 Gene Analysismentioning

confidence: 99%

Primers Designed For Amplifying TCF7L2 Gen

Syamsurizal¹,

Saputra²,

Putri³

et al. 2020

Biota

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Diabetes Mellitus (DM) is a disease characterized by high glucose levels because of the lack of insulin hormone in the body. Prevalence of Type-2 Diabetes Mellitus is associated with the variant of the TCF7L2 gene polymorphism, or SNP. The purpose of this study was to construct a specific primer to amplify the TCF7L2 gene fragment and their capabilities to detect the targeted area. This research was a descriptive study that design the primers using Geneious software version 5.4.7. The study was conducted at the Laboratory of Genetics and Biotechnology FMIPA Universitas Negeri Padang. Based on this research, a 10qF forward primer (NG_012631.1) and 10qR reverse primers (NG_012631.1) has successfully designed. The primers can amplify the targeted area of the TCF7L2 gene with 1208 bp length. The amplified gene region has many variants that are strictly related to the appearance of Type 2 Diabetes Mellitus.

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“…Despite the population heterogeneity in Middle East regarding the ethnic, income, and socioeconomic status, various risk factors are involved in diabetes such as aging, lifestyle change, reduced physical activity, and high calorie diet [ 13 ]. Genetic factors can also be associated with increased diabetes susceptibility [ 14 , 15 ]. Various genes are involved in the molecular mechanism of diabetes progression.…”

Section: Introductionmentioning

confidence: 99%

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

et al. 2022

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Diabetes is a chronic metabolic disorder that leads to the dysfunction of various tissues and organs, including eyes, kidneys, and cardiovascular system. According to the World Health Organization, diabetes prevalence is 8.8% globally among whom about 90% of cases are type 2 diabetes. There are not any significant clinical manifestations in the primary stages of diabetes. Therefore, screening can be an efficient way to reduce the diabetic complications. Over the recent decades, the prevalence of diabetes has increased alarmingly among the Middle East population, which has imposed exorbitant costs on the health care system in this region. Given that the genetic changes are among the important risk factors associated with predisposing people to diabetes, we examined the role of single-nucleotide polymorphisms (SNPs) in the pathogenesis of diabetes among Middle East population. In the present review, we assessed the molecular pathology of diabetes in the Middle East population that paves the way for introducing an efficient SNP-based diagnostic panel for diabetes screening among the Middle East population. Since, the Middle East has a population of 370 million people; the current review can be a reliable model for the introduction of SNP-based diagnostic panels in other populations and countries around the world.

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Genetic polymorphisms associated with type 2 diabetes in the Arab world: A systematic review and meta-analysis

Cited by 24 publications

References 72 publications

Epidemiology of type 2 diabetes in the Middle East and North Africa: Challenges and call for action

Epidemiology of type 2 diabetes in the Middle East and North Africa: Challenges and call for action

Primers Designed For Amplifying TCF7L2 Gen

Single-nucleotide polymorphisms as important risk factors of diabetes among Middle East population

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