Genetic parameters of milk productivity for three lactations of Holstein cattle with different genotypes of LEP gene

Ахметов, Т. М.; Safina, N.Yu.; Алимов, А. М.; Varlamova, M.I.

doi:10.1051/bioconf/20202700061

Cited by 3 publications

(3 citation statements)

References 10 publications

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“…The association of leptin gene polymorphism with the increase in milk yield and the quality of milk during three lactations of Holstein cows was revealed. Animals with the TT genotype for the LEP gene (c.73T > C) showed the best result for three lactations during the experiments [28]. Polymorphism of the LEP-Sau3AI was associated with the somatic cell count (SCC) (p ≤ 0.01), electrical conductivity (EC) (p ≤ 0.01), and pH (p ≤ 0.05) in Holstein cow milk.…”

Section: Candidate Genes With Predicted Functionsmentioning

confidence: 99%

Overview of SNPs Associated with Trans Fat Content in Cow’s Milk

2023

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Lipids consumed with milk derivatives are one of the main parts of the human diet. Trans fatty acids in milk are causing a debate about their impact on the incidence of cardiovascular disease, pathological abnormalities, and cancer. The fatty acid profile of milk is influenced by a large number of different factors, one of which is genetic. The development of genetic studies, including Genome-Wide Association Studies (GWAS), may help define genomic regions associated with fatty acid content in milk, including trans fatty acids. This article provides an overview of international studies on the identification of genomic regions and SNPs associated with the trans fatty acids in cow’s milk. The results are based on research of cattle such as Norwegian Red cattle, Holstein, Jersey, and Brown Swiss. The presented review shows that 68 SNPs were localized on chromosomes 1, 2, 4–6, 8–10, 12, 14–20, 22–25, and 27–29. Further research in this direction will provide new information that will serve as an impetus for the creation of modern breeding technologies and increase the performance of the manufacture of high-quality dairy products. The search for genetic markers associated with the content of TFA in milk is a promising direction in agricultural science and will allow more complete breeding work with cattle.

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Section: Candidate Genes With Predicted Functionsmentioning

confidence: 99%

Overview of SNPs Associated with Trans Fat Content in Cow’s Milk

2023

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“…Полученные данные указывают на разнообразие генетической структуры голштинской популяции крупного рогатого скота Республики Татарстан. Изучая ассоциации гена лептина с динамикой молочной продуктивности за три лактации коров голштинской породы выявлено, что наилучшие показатели по всем трем лактациям были выявлены в группе животных с генотипом TT гена LEP [ 19].…”

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Polymorphism of Lipid Metabolism Genes in Tatarstan-Type Cows

Lamara,

Ahmetov,

Shaydullin

et al. 2024

Agrobiotechnologies and Digital Farming

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The purpose of the research was to study the allelic polymorphism of lipid metabolism genes (OLR1, DGAT1 and LEP) in Tatarstan type cows. The object of the study was 79 first-calf heifers of the Kholmogory breed of the Tatarstan type, kept in the agricultural production complex “Agrofirm Rassvet” in the Kukmorsky district of the Republic of Tatarstan. As a result of molecular genetic studies (PCR-RFLP and AS-PCR), the animals were divided into groups taking into account their genotype at the loci of the low-density lipoprotein receptor (OLR1), diacylglycerol-O-acyltransferase (DGAT1) and leptin (LEP) genes. Animals with different genotypes of the studied genes were further divided into groups taking into account their linear affiliation. The studied sample of first-calf heifers consisted of individuals belonging to two leading genealogical lines of the Holstein breed, namely: Wis Ideal 933122 and Reflection Sovering 198998. In general, the studies showed that in the herd of first-calf heifers of the Tatarstan type, predominated allele C (0.73) and genotype CC 49.4% for OLR1 gene; allele A (0.77) and genotype AA 57.0% for DGAT1 gene; allele C (0.59) and genotype CT 57.0% for LEP gene. In the sample under study, the genetic balance is not shifted for any of the studied genes. In cows, the frequency of occurrence of alleles of the OLR1, DGAT1 and LEP genes, depending on linear affiliation (W. Ideal and R. Sovering), the trend remains. Similar data were obtained that, taking into account belonging to the Holstein breed, the highest occurrence of alleles in first-calf heifers: C (0.68-0.81) for OLR1 gene, A (0.74-0.83) for DGAT1 gene and C (0.57 -0.60) for LEP gene, respectively.

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“…Установлено, что в разрезе полиморфизма гена LEP в изученной голштинской выборке наилучшими продуктивными характеристиками, а также биологической эффективностью и полноценностью по качеству молока обладали первотёлки с генотипом CC [10]. Схожие результаты были получены на коровах татарстанского типа [11].…”

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Milk Productivity and Milk Quality of Cows With Different Lep Genotypes and Linear Affiliation

Lamara,

Zarubezhnova,

Ahmetov

et al. 2023

Agrobiotechnologies and Digital Farming

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A review of the scientific literature has shown that the genotype by loci of the Leptin (LEP) gene and linear affiliation to the leading Holstein breed of cows have an impact on milk productivity and the quality of their milk. The purpose of our research was to study the milk productivity and qualitative composition of the milk of Tatarstan-type cows with different genotypes according to the loci of the Leptin gene and linear belonging to the Holstein breed. The research was carried out in the conditions of the agricultural company "Agrofirma Rassvet" of the Kukmorsky district of the Republic of Tatarstan on the livestock of 79 cows of the Tatarstan type. The Tatarstan type is one of the leading dairy cattle breeds bred in the Republic of Tatarstan, and created by crossing the Kholmogorsky, Black and White, and Holstein breeds, while the bloodline was 1/8 Kholmogorsky + 1/16 Black and White + 13/16 Holstein. As a result of a molecular genetic study (PCR-RFLP), the animal population was sorted into groups, taking into account the genotype by the loci of the Leptin gene. The conducted studies have shown that in Tatarstan-type cows after the first lactation, the highest milk yield indicators, the amount of fat and protein in milk were noted in animals with the leptin gene genotypes LEP/CC and LEP/CT in comparison with peers of the LEP/TT genotype. However, in terms of the mass fraction of fat and protein in milk, the trend was reversed. Also, among the cows of the Tatarstan type, according to the first lactation, the highest values of milk productivity indicators (milk yield, amount of milk fat and protein) are in cows with the LEP/CC genotype of linear belonging to the Holstein breed, namely W. Ideal 933122 and R. Sovering 198998.

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Genetic parameters of milk productivity for three lactations of Holstein cattle with different genotypes of LEP gene

Cited by 3 publications

References 10 publications

Overview of SNPs Associated with Trans Fat Content in Cow’s Milk

Overview of SNPs Associated with Trans Fat Content in Cow’s Milk

Polymorphism of Lipid Metabolism Genes in Tatarstan-Type Cows

Milk Productivity and Milk Quality of Cows With Different Lep Genotypes and Linear Affiliation

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