Generation of an Adequate Perfusion Network within Dense Collagen Hydrogels Using Thermoplastic Polymers as Sacrificial Matrix to Promote Cell Viability
Abstract:Dense collagen hydrogels are promising biomaterials for several tissue-engineering applications. They exhibit high mechanical properties, similar to physiological extracellular matrices, and do not shrink under cellular activity. However, they suffer from several drawbacks, such as weak nutrient and O2 diffusion, impacting cell survival. Here, we report a novel strategy to create a perfusion system within dense and thick collagen hydrogels to promote cell viability. The 3D printing of a thermoplastic filament … Show more
“…A 600 µm diameter corresponds to the physiological range of a muscle bundle. Generating large channels by 3D printing is difficult without using sacrificial ink as channels tend to collapse [50]. For this reason, we used a molding method.…”
“…A 600 µm diameter corresponds to the physiological range of a muscle bundle. Generating large channels by 3D printing is difficult without using sacrificial ink as channels tend to collapse [50]. For this reason, we used a molding method.…”
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