Collagen scaffold impregnated with borosilicate bioactive glass for endometrial healing

Rezaeipour, Yashar; Alizadeh, Parvin; Keshavarz, Mozhgan

doi:10.1016/j.apmt.2022.101727

Cited by 3 publications

(1 citation statement)

References 110 publications

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“…It is also crucial for preserving the biological and structural integrity of ECM. The development and wound healing of organs and tissues, including skin, bone, the neurological system, and the vascular system, have all benefited from its exceptional biocompatibility and bioresorbability [ 50 , 51 ].…”

Section: Materials Used For 3d Scaffold Engineeringmentioning

confidence: 99%

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Vach Agocsova,

Culenova,

Birova

et al. 2023

Materials

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This article provides a thorough overview of the available resorbable biomaterials appropriate for producing replacements for damaged tissues. In addition, their various properties and application possibilities are discussed as well. Biomaterials are fundamental components in tissue engineering (TE) of scaffolds and play a critical role. They need to exhibit biocompatibility, bioactivity, biodegradability, and non-toxicity, to ensure their ability to function effectively with an appropriate host response. With ongoing research and advancements in biomaterials for medical implants, the objective of this review is to explore recently developed implantable scaffold materials for various tissues. The categorization of biomaterials in this paper includes fossil-based materials (e.g., PCL, PVA, PU, PEG, and PPF), natural or bio-based materials (e.g., HA, PLA, PHB, PHBV, chitosan, fibrin, collagen, starch, and hydrogels), and hybrid biomaterials (e.g., PCL/PLA, PCL/PEG, PLA/PEG, PLA/PHB PCL/collagen, PCL/chitosan, PCL/starch, and PLA/bioceramics). The application of these biomaterials in both hard and soft TE is considered, with a particular focus on their physicochemical, mechanical, and biological properties. Furthermore, the interactions between scaffolds and the host immune system in the context of scaffold-driven tissue regeneration are discussed. Additionally, the article briefly mentions the concept of in situ TE, which leverages the self-renewal capacities of affected tissues and highlights the crucial role played by biopolymer-based scaffolds in this strategy.

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Section: Materials Used For 3d Scaffold Engineeringmentioning

confidence: 99%

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Vach Agocsova,

Culenova,

Birova

et al. 2023

Materials

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Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration

Chen,

Li,

Zheng

et al. 2024

Exploration

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Scaffold‐based tissue engineering provides an efficient approach for repairing uterine tissue defects and restoring fertility. In the current study, a novel trilayer tissue engineering scaffold with high similarity to the uterine tissue in structure was designed and fabricated via 4D printing, electrospinning and 3D bioprinting for uterine regeneration. Highly stretchable poly(l‐lactide‐co‐trimethylene carbonate) (PLLA‐co‐TMC, “PTMC” in short)/thermoplastic polyurethane (TPU) polymer blend scaffolds were firstly made via 4D printing. To improve the biocompatibility, porous poly(lactic acid‐co‐glycolic acid) (PLGA)/gelatin methacryloyl (GelMA) fibers incorporated with polydopamine (PDA) particles were produced on PTMC/TPU scaffolds via electrospinning. Importantly, estradiol (E2) was encapsulated in PDA particles. The bilayer scaffolds thus produced could provide controlled and sustained release of E2. Subsequently, bone marrow derived mesenchymal stem cells (BMSCs) were mixed with gelatin methacryloyl (GelMA)‐based inks and the formulated bioinks were used to fabricate a cell‐laden hydrogel layer on the bilayer scaffolds via 3D bioprinting, forming ultimately biomimicking trilayer scaffolds for uterine tissue regeneration. The trilayer tissue engineering scaffolds thus formed exhibited a shape morphing ability by transforming from the planar shape to tubular structures when immersed in the culture medium at 37°C. The trilayer tissue engineering scaffolds under development would provide new insights for uterine tissue regeneration.

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Advances in Nanomedicine and Biomaterials for Endometrial Regeneration: A Comprehensive Review

Liu,

Jia,

et al. 2024

IJN

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The endometrium is an extremely important component of the uterus and is crucial for individual health and human reproduction. However, traditional methods still struggle to ideally repair the structure and function of damaged endometrium and restore fertility. Therefore, seeking and developing innovative technologies and materials has the potential to repair and regenerate damaged or diseased endometrium. The emergence and functionalization of various nanomedicine and biomaterials, as well as the proposal and development of regenerative medicine and tissue engineering techniques, have brought great hope for solving these problems. In this review, we will summarize various nanomedicine, biomaterials, and innovative technologies that contribute to endometrial regeneration, including nanoscale exosomes, nanomaterials, stem cell-based materials, naturally sourced biomaterials, chemically synthesized biomaterials, approaches and methods for functionalizing biomaterials, as well as the application of revolutionary new technologies such as organoids, organ-on-chips, artificial intelligence, etc. The diverse design and modification of new biomaterials endow them with new functionalities, such as microstructure or nanostructure, mechanical properties, biological functions, and cellular microenvironment regulation. It will provide new options for the regeneration of endometrium, bring new hope for the reconstruction and recovery of patients’ reproductive abilities.

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Collagen scaffold impregnated with borosilicate bioactive glass for endometrial healing

Cited by 3 publications

References 110 publications

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Resorbable Biomaterials Used for 3D Scaffolds in Tissue Engineering: A Review

Biomimicking trilayer scaffolds with controlled estradiol release for uterine tissue regeneration

Advances in Nanomedicine and Biomaterials for Endometrial Regeneration: A Comprehensive Review

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