Development of highly-reproducible hydrogel based bioink for regeneration of skin-tissues via 3-D bioprinting technology

Javed, Fatima; Mushtaq, Irrum; Rahman, Latifur; Ahmed, Nazir; Din, Israf Ud; Alotaibi, Mshari A.; Alharthi, Abdulrahman I.; Ahmad, Akil; Bakht, Md. Afroz; Khan, Fayyaz; Tasleem, S.

doi:10.1016/j.ijbiomac.2022.123131

Cited by 10 publications

(8 citation statements)

References 52 publications

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“…In this approach, the tissue thinness does not require printing a vascular network to nourish the it. Although keratinocytes have already been 3D-printed [39,40], there is no scientific evidence to date supporting the use of printed skin graft to replace traditionally harvested ones.…”

Section: Discussionmentioning

confidence: 99%

Stem Cells in Facial Regenerative Surgery: Current Clinical Applications. A Multidisciplinary, Systematic Review

Tel¹,

Miotti²,

Ius³

et al. 2023

Front. Biosci. (Landmark Ed)

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Background: Facial reconstruction represents one of the main challenges for surgeons. Stem cells (SC) represent the most studied solution for tissue regeneration. This approach appears particularly promising in combination with bioengineered scaffolds and 3D bioprinting. The purpose of this systematic review is to define the main domains of current application of SC therapy within contemporary clinical workflows, evaluate indications and limitations, report current knowledge in this innovative field of research, and define the landscape of evidence for such approaches. Methods: A systematic review was performed on the pertinent literature regarding stem cell-based cell therapies currently available in the reconstruction of the face. The review used the main databases for scientific literature based on the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: A total of 15 papers were selected after an independent search was performed. The two major domains for current application of stem cells in clinical practice were bone and skin categories. Conclusions: Cell therapy in the field of facial reconstruction represents a promising approach. The evidence regarding the current clinical use, however, seems to show this option to be limited. Bioengineering advances and the parallel development of 3D bioprinting technology can potentially enhance the role of stem cells in the future.

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Section: Discussionmentioning

confidence: 99%

Stem Cells in Facial Regenerative Surgery: Current Clinical Applications. A Multidisciplinary, Systematic Review

Tel¹,

Miotti²,

Ius³

et al. 2023

Front. Biosci. (Landmark Ed)

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“…Nanomaterials in bioinks improve flow behavior while maintaining mechanical properties, cytocompatibility, and biodegradability . Nanoclays like laponite contribute to good bioprintability, while GO, nicotinamide, and Fe 3+ influence properties like printability and stability. ,, These nanomaterials directly impact viscosity, biomaterial interaction, and cross-linking mechanisms, enhancing bioink functionality and performance.…”

Section: Effects Of Nanomaterials On Bioink Propertiesmentioning

confidence: 99%

“…Kilian et al explored a combination of alginate-methylcellulose (algMC) bioink and collagen-based artificial extracellular matrix (aECM), enhancing cell adhesion and differentiation potential . Ullah et al synthesized a bioink laden with human dermal fibroblasts and nicotinamide, achieving high cell survival and stable interactions . Sathish et al optimized a hydrogel bioink for cartilage tissue engineering, demonstrating reproducibility and high cell survival in meniscal scaffold fabrication .…”

Section: Nanomaterials-based Hybrid Bioinksmentioning

confidence: 99%

Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine

Chandra,

Reis,

Kundu

et al. 2024

ACS Biomater. Sci. Eng.

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3D bioprinting is recognized as the ultimate additive biomanufacturing technology in tissue engineering and regeneration, augmented with intelligent bioinks and bioprinters to construct tissues or organs, thereby eliminating the stipulation for artificial organs. For 3D bioprinting of soft tissues, such as kidneys, hearts, and other human body parts, formulations of bioink with enhanced bioinspired rheological and mechanical properties were essential. Nanomaterials-based hybrid bioinks have the potential to overcome the above-mentioned problem and require much attention among researchers. Natural and synthetic nanomaterials such as carbon nanotubes, graphene oxides, titanium oxides, nanosilicates, nanoclay, nanocellulose, etc. and their blended have been used in various 3D bioprinters as bioinks and benefitted enhanced bioprintability, biocompatibility, and biodegradability. A limited number of articles were published, and the above-mentioned requirement pushed us to write this review. We reviewed, explored, and discussed the nanomaterials and nanocomposite-based hybrid bioinks for the 3D bioprinting technology, 3D bioprinters properties, natural, synthetic, and nanomaterial-based hybrid bioinks, including applications with challenges, limitations, ethical considerations, potential solution for future perspective, and technological advancement of efficient and cost-effective 3D bioprinting methods in tissue regeneration and healthcare.

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“…Furthermore, this modification improved the self-healing properties of the bioink, making it suitable for skin injury treatments. 131 Constructing single-/multilayered 3D constructs resembling human skin structure and evaluating their functionality in vitro or in vivo is another interesting topic in the current research field. In 2017, Cubo et al used collagen matrix supplemented with human plasma to encapsulate fibroblasts and keratinocytes separately, creating a dermal−epidermal bilayer structure resembling human skin tissue.…”

Section: Neuralmentioning

confidence: 99%

“…By adding polyethylene glycol, the cross-link density of the bioink significantly increased, enhancing the viscosity and printability. Furthermore, this modification improved the self-healing properties of the bioink, making it suitable for skin injury treatments …”

Section: Bioinks For 3d Bioprinting Of Tissues and Organsmentioning

confidence: 99%

Recent Advancements of Bioinks for 3D Bioprinting of Human Tissues and Organs

He,

Deng,

et al. 2023

ACS Appl. Bio Mater.

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3D bioprinting is recognized as a promising biomanufacturing technology that enables the reproducible and high-throughput production of tissues and organs through the deposition of different bioinks. Especially, bioinks based on loaded cells allow for immediate cellularity upon printing, providing opportunities for enhanced cell differentiation for organ manufacturing and regeneration. Thus, extensive applications have been found in the field of tissue engineering. The performance of the bioinks determines the functionality of the entire printed construct throughout the bioprinting process. It is generally expected that bioinks should support the encapsulated cells to achieve their respective cellular functions and withstand normal physiological pressure exerted on the printed constructs. The bioinks should also exhibit a suitable printability for precise deposition of the constructs. These characteristics are essential for the functional development of tissues and organs in bioprinting and are often achieved through the combination of different biomaterials. In this review, we have discussed the cutting-edge outstanding performance of different bioinks for printing various human tissues and organs in recent years. We have also examined the current status of 3D bioprinting and discussed its future prospects in relieving or curing human health problems.

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Development of highly-reproducible hydrogel based bioink for regeneration of skin-tissues via 3-D bioprinting technology

Cited by 10 publications

References 52 publications

Stem Cells in Facial Regenerative Surgery: Current Clinical Applications. A Multidisciplinary, Systematic Review

Stem Cells in Facial Regenerative Surgery: Current Clinical Applications. A Multidisciplinary, Systematic Review

Nanomaterials-Based Hybrid Bioink Platforms in Advancing 3D Bioprinting Technologies for Regenerative Medicine

Recent Advancements of Bioinks for 3D Bioprinting of Human Tissues and Organs

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