General Aspects of Adverse Cutaneous Drug Reactions

Özkaya, Esen; Yazganoğlu, Kurtuluş Didem

doi:10.1007/978-1-4471-6536-1_1

Cited by 3 publications

(1 citation statement)

References 110 publications

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“…Puede acompañarse de síntomas como ardor y picazón. Las lesiones generalmente curan con hiperpigmentación residual (12). siguientes: edad >40 años, malignidad asociada, frecuencia cardíaca >120/min, desprendimiento epidérmico >10%, uremia >28 mg/dL, glicemia >252 mg/dL, bicarbonato menor a 20 mEq/L.…”

Section: Net (Necrólisis Epidérmica Tóxica)unclassified

Farmacodermias por antibióticos

González

Brener

2020

SALUD MIL

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Antibiotic pharmacoderma RESUMENLas farmacodermias son enfermedades de la piel causadas por medicamentos. Constituyen una complicación frecuente en la práctica médica diaria. Este tipo de reacciones representan el 30% de las reacciones medicamentosas adversas y el 5% de las consultas dermatológicas. El médico clínico cumple un rol fundamental en el diagnóstico siendo el dermatólogo quien mejor puede definir los patrones clínicos de manifestaciones cutáneas y colaborar en la identificación del agente causal. Son consideradas como grandes simuladoras, desde formas leves en la mayoría de casos a reacciones cutáneas graves con riesgo vital que alcanzan un 2% de los casos. Todo tratamiento farmacológico puede causar una farmacodermia, la mayoría de episodios producidos por unos pocos grupos, destacando dentro de los más implicados a los antibacterianos. El diagnóstico está basado en la clínica, la asociación a algún fármaco y su correlación con los hallazgos histopatológicos. La piedra angular del tratamiento radica en la identificación y pronta retirada del fármaco sospechoso. Se realiza una revisión descriptiva de reacciones cutáneas adversas producidas por administración de antibacterianos, describiendo los frecuentemente implicados así como los distintos patrones morfológicos de presentación.

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Section: Net (Necrólisis Epidérmica Tóxica)unclassified

Farmacodermias por antibióticos

González

Brener

2020

SALUD MIL

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Eczematous Drug Eruptions

Blum

Burgin

2021

Am J Clin Dermatol

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In vitro antioxidant and antihypertensive properties of sesame seed enzymatic protein hydrolysate and ultrafiltration peptide fractions

et al. 2020

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The objective of this study was to determine the in vitro antioxidant and antihypertensive potentials of sesame seed protein hydrolysate and its membrane ultrafiltration peptide fractions in comparison to the unhydrolyzed protein. Sesame seed protein isolate (SESPI) was prepared from the defatted sesame seed meal and then hydrolyzed using consecutive additions of pepsin and pancreatin to yield sesame protein hydrolysate (SESPH). The SESPH was subjected to membrane ultrafiltration consecutively to obtain fractions with peptide sizes of <1, 1-3, 3-5, and 5-10 kDa, respectively, which were then assayed for in vitro antioxidant and antihypertensive properties. The results showed that protein hydrolysis and fractionation led to significant (p < .05) increases in the content of hydrophobic amino acids. Radical scavenging and metal ion chelation were also significantly (p < .05) enhanced by these treatments. Inhibition of linoleic acid oxidation was stronger with the 1.0 mg/ml of sesame peptide samples in comparison to the mild inhibitory effect exhibited by the 0.5 mg/ml of samples. The <1 kDa peptide fraction was the most active inhibitor (81%) against angiotensin converting enzyme, whereas the bigger peptides (>3-5 and 5-10 kDa) were the most effective (75%-85%) inhibitors against renin. These sesame products could be used as therapeutic agents in the development of health enhancing foods for the prevention and management of chronic diseases. Practical applications Bioactive peptides have been produced from plant protein sources through in vitro enzymatic activities. Sesame seed peptides have demonstrated multifunctional potential to act as antioxidative and antihypertensive agents that could be utilized as ingredients for the development of novel functional foods and nutraceuticals.

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General Aspects of Adverse Cutaneous Drug Reactions

Cited by 3 publications

References 110 publications

Farmacodermias por antibióticos

Farmacodermias por antibióticos

Eczematous Drug Eruptions

In vitro antioxidant and antihypertensive properties of sesame seed enzymatic protein hydrolysate and ultrafiltration peptide fractions

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