Gender and age prevalence distributions of morphea en plaque and anogenital lichen sclerosus

Abstract

2 Hrushesky WJ. Unusual pigmentary changes associated with 5-fluorouracil therapy. Cutis 1980; 26 : 181-182. 3 Falkson G, Schulz EJ. Skin changes in patients treated with 5-fluorouracil. Br J Dermatol 1962; 74 : 229-236. 4 Vukelja SJ, Bonner MW, McCollough M et al. Unusual serpentine hyperpigmentation associated with 5fluorouracil. Case report and review of cutaneous manifestations associated with systemic 5-fluorouracil. J Am Acad Dermatol 1991; 25 : 905-908. 5 Bogenrieder T, Weitzel C, Scholmerich J et al. Eruptive multiple lentigo-maligna-like lesions in a patient undergoing chemotherapy with an oral 5-fluorouracil prodrug for metastasizing colorectal carcinoma: a lesson for the pathogenesis of malignant melanoma? Dermatology 2002; 205 : 174-175. 6 Tucker MA, Misfeldt D, Coleman CN et al. Cutaneous malignant melanoma after Hodgkin's disease. Ann Intern Med 1985; 102 : 37-41. 7 Duvic M, Lowe L, Rapini RP et al. Eruptive dysplastic nevi associated with human immunodeficiency virus infection. Arch Dermatol 1989; 125 : 397-401. 8 Betlloch I, Amador C, Chiner E et al. Eruptive melanocytic nevi in human immunodeficiency virus infection. Int J Dermatol 1991; 30 : 303. 9 Richert S, Bloom EJ, Flynn K, Seraly MP. Widespread eruptive dermal and atypical melanocytic nevi in association with chronic myelocytic leukemia: case report and review of the literature. J Am Acad Dermatol 1996; 35 : 326-329. 10 Fukushima S, Hatta N. Atypical moles in a patient undergoing chemotherapy with oral 5-fluorouracil prodrug.

Evidence‐based (S3) Guideline on (anogenital) Lichen sclerosus

“…Women seem more affected than men, with a reported female: male ratio between 3:1 and 10:1; however, an equal gender distribution was observed in a Greek general hospital (Wallace 1971;Meffert 1995;Leibovitz 2000;Jensen 2012;Kyriakis 2007;Garcia-Bravo 1988;Steigleder 1976;).…”

Quality of life in Dutch women with lichen sclerosus

“…4 LS can occur at any age, but there are two main peaks in incidence in both women and men. 9,10 In children 11 the female ⁄ male ratio appears to be reversed. 5,6 Although LS affects female and male individuals, the incidence in women is much higher; some studies have shown a female ⁄male ratio of 10 : 1, others of 6 : 1.…”

“…7,8 The prevalence is estimated to be between 1 in 30 and 1 in 1000. 9,10 In children 11 the female ⁄ male ratio appears to be reversed. The estimated prevalence in girls aged 2-16 years is estimated to be 1 in 900; 12 in boys aged 0-14 years it is estimated to be 1 in 200.…”

The Aetiopathogenesis of Male Genital Lichen Sclerosus (MGLSc)

“…The epidemiology will necessarily vary between countries and racial groups because MGLSc is essentially a disease of the uncircumcised; indeed it is a common reason for circumcision in boyhood and adulthood and there is a bimodal age incidence with peaks in young boys and in adult men, late in the fourth decade. [3][4][5][6][7] The presentation of MGLSc of the penis varies. It may be asymptomatic.…”