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625This case shows that scleroderma may be associated with LVHT and neuromuscular disoerders. The frequent association of neuromuscular disorders with LVHT and the frequent association of cutaneous sclerosis with myopathy suggests a common aetiology of the described abnormalities. Isolated noncompaction of left ventricular myocardium. A study of eight cases. Circulation 1990; 82: 507-513. 5 Ringel R, Brick JE, Brick JF, Gutmann L, Riggs JE. Muscle involvement in the scleroderma syndromes. Arch Intern Med 1990; 150: 2550 -2552. 6 Lakhanpal S, Ginsburg WW, Michet CJ, Davis JA, Moore SB. Eosinophilic fasciitis: clinical spectrum and therapeutic response in 52 cases. Semin Arthritis Rheum 1988; 17: 221-231. 7 Chen L, Lee L, Kudlow BA et al. LMNA mutations in atypical Werner's syndrome. Lancet 2003; 362: 440 -445. 8 Margolin L. Non-L-tryptophan related eosinophiliamyalgia syndrome with hypoproteinemia and hypoalbuminemia. J Rheumatol 2003; 30: 628-629. 9 Finsterer J, Stöllberger C, Feichtinger H. Histological appearance of left ventricular hypertrabeculation / noncompaction. Cardiology 2002; 98: 162-164. 10 Stöllberger C, Finsterer J, Blazek G. Left ventricular hypertrabeculation/noncompaction and association with additional cardiac abnormalities and neuromuscular disorders. Am J Cardiol 2002; 90: 899 -902.

2 Hrushesky WJ. Unusual pigmentary changes associated with 5-fluorouracil therapy. Cutis 1980; 26 : 181-182. 3 Falkson G, Schulz EJ. Skin changes in patients treated with 5-fluorouracil. Br J Dermatol 1962; 74 : 229-236. 4 Vukelja SJ, Bonner MW, McCollough M et al. Unusual serpentine hyperpigmentation associated with 5fluorouracil. Case report and review of cutaneous manifestations associated with systemic 5-fluorouracil. J Am Acad Dermatol 1991; 25 : 905-908. 5 Bogenrieder T, Weitzel C, Scholmerich J et al. Eruptive multiple lentigo-maligna-like lesions in a patient undergoing chemotherapy with an oral 5-fluorouracil prodrug for metastasizing colorectal carcinoma: a lesson for the pathogenesis of malignant melanoma? Dermatology 2002; 205 : 174-175. 6 Tucker MA, Misfeldt D, Coleman CN et al. Cutaneous malignant melanoma after Hodgkin's disease. Ann Intern Med 1985; 102 : 37-41. 7 Duvic M, Lowe L, Rapini RP et al. Eruptive dysplastic nevi associated with human immunodeficiency virus infection. Arch Dermatol 1989; 125 : 397-401. 8 Betlloch I, Amador C, Chiner E et al. Eruptive melanocytic nevi in human immunodeficiency virus infection. Int J Dermatol 1991; 30 : 303. 9 Richert S, Bloom EJ, Flynn K, Seraly MP. Widespread eruptive dermal and atypical melanocytic nevi in association with chronic myelocytic leukemia: case report and review of the literature. J Am Acad Dermatol 1996; 35 : 326-329. 10 Fukushima S, Hatta N. Atypical moles in a patient undergoing chemotherapy with oral 5-fluorouracil prodrug.

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