The Aetiopathogenesis of Male Genital Lichen Sclerosus (MGLSc)

Shim, TN; Bunker, C.B.

doi:10.3126/njdvl.v11i1.7929

Cited by 1 publication

(2 citation statements)

References 41 publications

(62 reference statements)

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“…Our understanding of the role of occlusional contact with urine in the pathogenesis is fundamental to the effective management and the prognosis of MGLSc. [ 65 89 ]…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

“…Short, trimmed pubic hair is recommended to avoid hair trapping between the foreskin and the glans penis and hence minimize irritation, abrasion and consequent inflammation. [ 89 ] Early aggressive treatment may prevent disease progression. [ 91 ] An ultrapotent topical corticosteroid (usually clobetasol propionate (level evidence I)) used under supervision for a finite course is effective[ 2 92 93 94 ] and usually problem free, but herpes simplex and wart reactivation do occur.…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Male genital lichen sclerosus

Bunker

Shim²

2015

Indian J Dermatol

104

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Male genital lichen sclerosus (MGLSc) is a chronic inflammatory skin disease responsible for male sexual dyspareunia and urological morbidity. An afeared complication is squamous cell carcinoma (SCC) of the penis. The precise etiopathogenesis of MGLSc remains controversial although genetic, autoimmune and infective (such as human papillomavirus (HPV) hepatitis C (HCV), Epstein-Barr virus (EBV) and Borrelia) factors have been implicated: Consideration of all the evidence suggests that chronic exposure of susceptible epithelium to urinary occlusion by the foreskin seems the most likely pathomechanism. The mainstay of treatment is topical ultrapotent corticosteroid therapy. Surgery is indicated for cases unresponsive to topical corticosteroid therapy, phimosis, meatal stenosis, urethral stricture, carcinoma in situ (CIS) and squamous cell carcinoma.

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“…Our understanding of the role of occlusional contact with urine in the pathogenesis is fundamental to the effective management and the prognosis of MGLSc. [ 65 89 ]…”

Section: Diagnosis and Treatmentmentioning

confidence: 99%