Gatifloxacin 200 mg or 400 mg once daily is as effective as ciprofloxacin 500 mg twice daily for the treatment of patients with acute pyelonephritis or complicated urinary tract infections

Clinical efficacy of oral administration of 200mg gatifloxacin once daily for 3 days for the treatment of patients with uncomplicated cystitis

“…Of note, A single dose of 400 mg gatifl oxacin may exhibit clinical efficacy and utility similar to that of 200 mg in Japanese women, as shown in previous studies. 4,9 In the present study, E. coli was found in in 76 of 102 patients (74.5%) as a single causative pathogen and as one of multiple pathogens in 13.7%, and the susceptibility rate of E. coli isolates to gatifl oxacin was 92.2%. In addition, gatifl oxacin demonstrated high in vitro inhibition rates for other pathogens, including both gram-positive and Grade Micturition pain Pollakisuria Urinary urgency Suprapubic pain 0 1 2 3 0 1 2 3 0 1 2 3 0 1 2 3 First visit 12 35 41 14 12 42 39 9 41 41 17 3 14 60 25 3 After treatment 96 5 1 0 85 14 2 1 98 3 1 0 93 7 1 1 -negative bacteria, showing that the overall susceptibility rate was 93.2%.…”

“…Recently, Naber et al 4 compared the effi cacy of two oral dosing regimens of gatifl oxacin (200 mg once daily for 3 days and 400 mg as a single dose) with ciprofl oxacin (250 mg twice daily for 3 days) for the treatment of acute uncomplicated cystitis, and they reported that both regimens of gatifl oxacin were equivalent to ciprofl oxacin. In that study, the clinical cure rates of the three treatment groups were 85.2%, 81.1%, and 84.5%, respectively, at 7-9 days after treatment, and 88.0%, 81.6%, and 85.8%, respectively, at 4-6 weeks after treatment.…”

“…3 The postantibiotic effects (PAEs) of gatifl oxacin against several pathogens ranged from 0.5 to 4.1 h, and pre-exposure concentrations of gatifl oxacin of 4 and 10 times the minimum inhibitory concentration (MIC), producing longer PAEs, were within clinically achievable gatifl oxacin concentrations for several strains, suggesting that serum gatifl oxacin concentrations exceed the MICs during the entire 24-h dosage interval recommended for the drug. 3 Recently, Naber et al 4 have reported that the administration of gatifl oxacin 200 mg once daily for 3 days, as well as a single dose of 400 mg, was equivalent to ciprofl oxacin 250 mg twice daily for 3 days for the treatment of acute lower UTI. In the present study, to assess the clinical effi cacy of gatifl oxacin for acute uncomplicated cystitis in Japanese women, 200 mg gatifl oxacin was administered once daily for 3 days and the short-and long-term clinical outcomes were evaluated.…”

Therapie der akuten unkomplizierten Harnweginfektion

“…Ciprofloxacin [49] 500 mg 2x/Tag 7 Ciprofloxacin XR [50] 1000 mg 1x/Tag 7-10 Cefpodoximproxetil [52] 200 mg 2x/Tag 10 Gatifloxacin [51] 400 mg 1x/Tag 10 Levofloxacin [33] 250(-500) mg 1x/Tag 10 Lomefloxacin [33] 400 mg 1x/Tag 10 TMP-SMX a [48,50] 160/800 mg 2x/Tag 14 a Nur bei sensibel getesteten Erreger. Ciprofloxacin XR Ciprofloxacin extended release, TMP Trimethoprim, SMX Sulfamethoxazol.…”

“…Die folgenden Schlussfolgerungen können für die Initialtherapie der akuten unkomplizierten Pyelonephritis aus der Analyse der IDSA und 5 neueren Studien [33,49,50,51] …”