Clinical efficacy of oral administration of 200mg gatifloxacin once daily for 3 days for the treatment of patients with uncomplicated cystitis

Current therapy of acute uncomplicated cystitis

“…This suggests that strains that belong to these two clonal groups play a major role in determining the high rate of fluoroquinolone‐resistant E. coli strains observed in the community 30 . In Japan, it has been reported that fluoroquinolone‐resistant E. coli accounted for 8% of isolates from patients with uncomplicated UTI in 2001, 31 and this resistance rate was similar to that in our previous study in 2008 12 . However, in South Korea, it has been shown that the resistance rates of E. coli isolated from AUC to ciprofloxacin increased from 15.2% in 2002 to 23.4% in 2006, which indicates that re‐evaluation of the guidelines for empirical therapy for AUC is required 32 …”

“…In recent studies from the United States, TMP/SMX resistance rates have accounted for 15–23% of isolates from patients with AUC 28,29 . In our recent study, 17% of isolates from patients with AUC showed TMP/SMX resistance, which indicated that TMP/SMX might no longer be a candidate for first‐line therapy of AUC in Japan 12 …”

“… Pathogens isolated from 102 patients with uncomplicated cystitis in Japan 12 . CNS, coagulase negative staphylococci.…”

Current Management Strategies for Uncomplicated and Complicated Cystitis

“…Recent studies from the United States have demonstrated TMP-SMX resistance rates of 15% to 23% in isolates from patients with acute uncomplicated cystitis (Colgan et al 2008, Hames andRice 2007). In a study from Japan 17% of isolates from patients with cystitis showed resistance to TMP-SMX and abandonment of TMP-SMX as first line therapy for acute uncomplicated cystitis is currently under consideration in this region (Yamamoto et al 2009). Resistant strains can be partially predicted from a history of recent antimicrobial usage.…”

“…This implies that strains belonging to these two clonal groups play a major role in determining the increasing rate of flouroquinolone resistant E. coli strains in the community. One study from Japan reported fluoroquinolone resistance in 8% of isolates from patients with acute uncomplicated cystitis (Yamamoto et al 2009). Worryingly, resistance rates for E. coli isolated from acute uncomplicated cystitis to ciprofloxacin increased from 15.2% in 2002 to 23.4% in 2006 in South Korea (Yamamoto et al 2010) (Fig.…”