Gastroprotective effects of CoQ10 on ethanol-induced acute gastric lesions

Abstract

Abstract:Introduction: Alcohol consumption is frequently associated with gastric mucosal lesions. The purpose of this study was to determine the effect of Coenzyme-Q 10 (CoQ 10 ) supplementation on the ethanol-induced gastric mucosal damage in a rat model. Material and method: Sixty-four female wistar albino rats were randomly divided into 8 groups (n = 8). Studies were performed in ethanol induced gastric ulcer model in Wistar albino rats. Famotidine at a dose of 5 mg/kg or 20 mg/kg and CoQ 10 at a single dose of 10 mg/kg or 20 mg/kg and 30 mg/kg for 7 days were administered as pretreatment. All the rats in study groups received 2 ml/kg ethanol 95 % intragastrically, 30 minutes after pretreatment. Four hour after ethanol administration, all rats were sacrifi ced and their stomachs were removed under ketamin anaesthesia. Gastric protection was evaluated by measuring the ulcer index, MDA concentrations, and histopathological studies. Results and discussion: Rats pretreated either with famotidine or CoQ 10 had signifi cantly diminished gastric mucosal damage which was assessed with gross and microscopic analysis (p < 0.00625). MDA levels were signifi cantly lower in famotidine 20 mg/kg and CoQ 10 pretreatment for 7 days group (p < 0.00625). Conclusion: CoQ 10 affords gastroprotection against ethanol-induced gastric mucosal lesions in rats especially after repetitive administrations (Tab. 3, Fig. 2, Ref. 35). Text in PDF www.elis.sk.

Evaluation of Gastroprotective Effect of Coenzyme Q 10 and L - Glutamine in Stress and Ethanol-Induced Peptic Ulcer in Wistar Rats: A Novel Preclinical Study

“…We noted that CoQ10 group had no ulcer formation and its efficacy was better than pantoprazole and sucralfate. There is only one preclinical study reporting the use of CoQ10 on ethanol-induced ulcer in rats [8]. The results of that study showed that CoQ10 when used in combination with famotidine had better gastric protection.…”

“…The study also revealed single dose of CoQ10 was not useful and multiple doses are required to achieve therapeutic concentrations in gastric tissue [8]. In another study, CoQ10 at high dose was used in indomethacin-induced gastric ulcers in rats and was found to have good gastric protection [9].…”

“…Coenzyme Q 10 (CoQ10) and L-glutamine have antioxidant property, and their role as antioxidants has been documented in the literature in treating medical conditions [5,6]. Their role in peptic ulcer diseases is not well known with only few studies reporting the use of CoQ10 and L -glutamine in peptic ulcer treatment in animals and no human studies have been done so far [7,8]. Hence, the aim of present study is to evaluate the gastroprotective role of CoQ10 and L-glutamine in stress and ethanol-induced peptic ulcers in Wistar albino rats.…”

Pharmacotherapy of Peptic Ulcer Disease and Latest Research

“…Antioxidants help in scavenging the free radicals and controlling the oxidative stress responsible for the progression of peptic ulcer [2]. Coenzyme Q10 (CoQ10) and L-glutamine have antioxidant property, and their role as antioxidants has been documented in the literature in treating medical conditions [5][6][7][8].…”

Is Coenzyme Q₁₀ Effective in Protection against Ulcerative Colitis? An Experimental Study in Rats

“…14) We performed a pilot trial using 3 oral doses of Co-Q 10 , namely 20, 30 and 40 mg/kg/d once daily and presented a graph of inflammatory scoring. The dose of 30 mg/kg showed better results compared with that of 20 mg/kg.…”