Gastroprotective effect of standardized leaf extract from Argyreia speciosa on experimental gastric ulcers in rats

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

“…Pylorus ligation-induced ulcer is due to autodigestion of the gastric mucosa and breaks down of the gastric mucosal barrier (Sairam et al 2002). Ethanol-induced gastric ulcers was reported to stimulate the formation of leukotriene C4 (LTC4), the neutrophil cells activation, the production of reactive oxygen species which in turn produces a direct gastric necrotizing action and reduces defensive factors like the secretion of bicarbonate and production of mucus (Jaiswal et al 2011). Rather than inducing ulcer, ethanol could diffuse to the whole body and induced hematological and metabolism perturbation (Husain et al 2001), for these reasons we chose ethanol to induce gastric ulcer.…”

Medicinal plants with gastroprotective potential

“…Gastroprotective potential of butanol fraction of A. speciosa leaf against aspirin-, pylorus ligation-, ethanoland stress-induced ulcerative damage has been explored in rats (Jaiswal et al, 2011). Leaf extract was used at three different doses (50, 100 and 200 mg/kg).…”

Gastroprotective Effect of Vetiveria Zezanioides in Experimental Animals

“…Hence decrease in SOD and CAT levels may lead to increase in accumulation of these ROS therefore results in increased lipid peroxidation and tissue damage. Glutathione is scavenger of free radicals in the cytoplasm that inhibits free radical mediated lipid peroxidation and thus inhibits formation of ulcer 10 . This free radical scavenging activity is impaired in acute and chronic ulceration in gastric mucosa 11 .…”

“…4,5 Remedies from Ayurvedic or traditional medicinal system can be the alternative approach in recent days to overcome the adverse effects of drugs like NSAID's. The use of medicinal plants like Aloe, Terminalia Chebula, Ginseng, Capsicum 6,7 , Rubia cordifolia 8 , Capparis zeylanica 9 , Argyreia speciosa 10 , Jasminum grandiflorum 11 , Heliotropium indicum 12 as drug therapy to treat ulcers has proved to be clinically effective and less relatively toxic than the existing drugs and also reduces the offensive factors serving as a tool in the prevention of peptic ulcer.…”