Gastroprotective Effect of Vetiveria Zezanioides in Experimental Animals

Abstract

The aim of the study was to evaluate gastroprotective effect of Vetiveria zizanioides in experimental animals. The ethanolic extract of roots of Vetiveria zizanioides (VZ) was screened for gastroprotective activity by using Aspirin+ pylorus ligation induced peptic ulcers in rats in which ulcer index, gastric wall mucus, antioxidant enzyme level like SOD, GSH, Catalase, & LPO in stomach were determined. It was found that animals belonging to VZ group reduced the ulcer index, increased mucus content as well as restored the antioxidant parameters in stomach and increased pH of gastric juice, decreased gastric volume and total acidity significantly as compared to ulcerated group of animals. VZ showed significant gastroprotective activity which may be due to increase in mucus secretion as well as free radicals scavenging activity in stomach.