Protective roles of Vigna subterranea (Bambara nut) in rats with aspirin-induced gastric mucosal injury

Balogun, Morufu E.; Besong, E E; Obimma, Jacinta Nkechi; Mbamalu, Ogochukwu Sophia; Djobissie, Fankou Serges Athanase

doi:10.1016/j.joim.2018.07.004

Cited by 8 publications

(6 citation statements)

References 29 publications

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“…Balogun et al. (2018) also suggested that Bambara nut exerted a protective effect against gastric ulcers in Wistar rats, which was mediated via antioxidative mechanisms. Yang et al.…”

Section: Resultsmentioning

confidence: 99%

“…It was concluded that the oral liquid attenuated gastric mucosal damage induced by ethanol in rats through antioxidant mechanisms. Balogun et al (2018) also suggested that Bambara nut exerted a protective effect against gastric ulcers in Wistar rats, which was mediated via antioxidative mechanisms. Yang et al (2017) demonstrated that aucubin showed a protective effect against ethanol-induced acute gastric mucosal injury through its antioxidant effects.…”

Section: 83mentioning

confidence: 97%

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Development of a compound oral liquid containing herbal extracts and its effect on immunity and gastric mucosa

Pei

Lou

Zhang

et al. 2021

Journal of Food Science

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Nowadays, consumers have an increasing demand for health products. In this study, an oral liquid was developed using a compound extract consisting of three herbal extracts (Dendrobium nobile Lindl., Lycium barbarum, and Puerariae lobatae Radix) because the compound extract (a combination of all three extracts) was superior to every single extract in promoting the phagocytic capacity of RAW264.7 macrophages and the proliferation ability of GES‐1 cells. In this oral liquid, the dosage of the stabilizer and the sweetener was selected using a stability test and sensory quality evaluation. When 0.30% (m/v) xanthan gum and 0.20% (m/v) mogroside were added, the oral liquid had not only a good stability but also the highest sensory score for overall acceptability. The chemical composition analysis showed that the oral liquid had various functional ingredients including polysaccharides, phenols, alkaloids, and so forth. The immune‐enhancing efficacy of the oral liquid was evaluated in BALB/c mice by measuring the levels of different immune indicators. The results indicated that the oral liquid obviously enhanced nonspecific and specific immunity. A rat model with ethanol‐induced gastric ulcer was used to examine the protective effect of the oral liquid on the gastric mucosa and to explore the related mechanisms. The oral administration of the oral liquid for days significantly prevented the formation of gastric ulcer. This study provided an effective oral liquid that could enhance immunity and protect gastric mucosa.

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“…Balogun et al. (2018) also suggested that Bambara nut exerted a protective effect against gastric ulcers in Wistar rats, which was mediated via antioxidative mechanisms. Yang et al.…”

Section: Resultsmentioning

confidence: 99%

Section: 83mentioning

confidence: 97%

Development of a compound oral liquid containing herbal extracts and its effect on immunity and gastric mucosa

Pei

Lou

Zhang

et al. 2021

Journal of Food Science

View full text Add to dashboard Cite

show abstract

“…During the healing process, there is a need for complex biological responses such as reduced inflammation, reduced oxidative effect, gastric cell regeneration, cell proliferation, migration, differentiation, gland reconstruction, granulation tissue formation, and neovascularization [3,7,86]. These responses are modulated by CO, glutathione peroxidase enzyme (GSH-Px), Cu/Zn superoxide dismutase (SOD), catalase (CAT), PGs, NO, sulfhydryl compounds, epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) and the peroxisome proliferator-activator receptor gamma (PPAR-γ) [7,10,59,75,[89][90][91][92][93].…”

Section: Ability To Repair the Mucosamentioning

confidence: 99%

“…Increased production of endogenous PGs may result in increased gastric mucosal resistance against harmful agents, such as ethanol [51]. Particularly, PGs E 2 and I 2 amplify the secretion of bicarbonate and mucus contributing to the balance of gastric pH, maintain the blood flow of the gastric mucosa and coordinate the defense, renewal, and repair of the mucosal epithelial cells [45,70,[93][94][95]. In addition, PGE 2 via the EP receptor can inhibit acid secretion and histamine release by parietal cells and enterochromaffin-like cells, respectively [95].…”

Section: Ability To Repair the Mucosamentioning

confidence: 99%

Gastroprotective Mechanisms

Lima¹,

Lima²,

Souza³

et al. 2022

Peptic Ulcer Disease - What's New?

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Gastric ulcer (GU), a common type of peptic ulcer, results from an imbalance in the action of protective and aggressive agents. Gastroprotective mechanisms are mucus layer, gastric epithelium, gastric blood flow, gastric neurons, mucosal repair capacity, and immune system. Thus, the aim of this chapter was to provide an update on gastroprotective mechanisms. It was carried out through searches in PubMed covering the years 2016–2021 using several keywords. This survey resulted in 428 articles, of which 110 were cited in this chapter. It was reviewed the status of gastroprotective mechanisms and highlighted that mucins can act as a filter; gastric epithelial defenses are composed of the cell barrier, stem cells, and sensors on the mucosal surface; nitric oxide (NO) and hydrogen sulfide (H2S) act for gastric blood flow homeostasis (GBF); the main effector neurons in the gastric mucosa are cholinergic, nitrergic and VIPergic, and oxytocin can activate neurons; repair of the gastric mucosa requires complex biological responses; the immune system regulates the entry of antigens and pathogens. The main knowledge about gastroprotective mechanisms remains unchanged. However, we conclude that there has been progressing in this area.

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“…Vigna subterranea and V. unguiculata are native to the African region, whereas Phaseolus vulgaris and Vigna radiata originate from Latin and Central America, and India, respectively. Currently, they are extensively cultivated all over the world [6][7][8][9]. These beans have a high nutrient value, are crucial for nutritional and food security, and reduce mal-and sub-nutrition levels in developing countries, above all in sub-Saharan Africa [10,11] but also in densely populated countries such as India [12].…”

Section: Introductionmentioning

confidence: 99%

Food Security and Nutrition in Mozambique: Comparative Study with Bean Species Commercialised in Informal Markets

et al. 2021

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In Mozambique (South-eastern Africa), Phaseolus vulgaris and Vigna spp. are important staple foods and a major source of dietary protein for local populations, particularly for people living in rural areas who lack the financial capacity to include meat in their daily dietary options. This study focuses on the potential for improving diets with locally produced nutritious legumes whilst increasing food security and income generation among smallholder farmers. Using bean species and varieties commercialised as dry legumes in the country, it sets out to characterize and compare the chemical properties of Phaseolus vulgaris and Vigna spp. among the most commercialised dry legume groups in Mozambique. The principal component analysis showed a clear separation between Phaseolus and Vigna species in terms of proximate composition, whereas protein content was quite uniform in both groups. It concludes that the introduction of improved cultivars of Phaseolus vulgaris and Vigna species maize–legume intercropping benefits yield, diets and increases household income with limited and low-cost inputs while enhancing the resilience of smallholder farmers in vulnerable production systems affected by recurrent drought and the supply of legumes to urban informal markets.

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Protective roles of Vigna subterranea (Bambara nut) in rats with aspirin-induced gastric mucosal injury

Cited by 8 publications

References 29 publications

Development of a compound oral liquid containing herbal extracts and its effect on immunity and gastric mucosa

Development of a compound oral liquid containing herbal extracts and its effect on immunity and gastric mucosa

Gastroprotective Mechanisms

Food Security and Nutrition in Mozambique: Comparative Study with Bean Species Commercialised in Informal Markets

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