Medicinal plants with gastroprotective potential

Majeed, Wafa; Khaliq, Tanweer; Aslam, Bilal; Khan, Junaid; Iftikhar, Asra

doi:10.3329/bjp.v10i3.23578

Cited by 6 publications

(5 citation statements)

References 62 publications

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“…Our results were also comparable with previous reports of other natural gastroprotective agents i.e. Acanthus ilicifolius, Anogeissus latifolia, Berberis vulgaris & Argyreia speciose etc [38]. Based upon the findings of the present investigation, it is quite evident that Lavandula stoechas L. extract possessed antimicrobial activity against Proteus mirabilis and also proved effective against ethanol-induced ulcers in animal model.…”

Section: Discussionsupporting

confidence: 92%

Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer

Javed

Khan

Arshad³

et al. 2020

RADS J. Pharm. Pharm. Sci.

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Background: The constituents of Lavandula stoechas L. possess antioxidant properties that help in protecting the mucosal cells from oxidative damage and speed up the healing process however, its role in the treatment of ethanol-induced peptic ulcers is not clear. Objectives: We aimed to evaluate the pharmacological potential of Lavandula stoechas L. extracts for anti-ulcer activity, and compare with the standard drugs and to explore novel treatment for peptic ulcer. Methods: We evaluated anti-ulcer potential of plant extract in ethanol-induced ulcer model in rats. Omeprazole and ranitidine were standard drugs. After 5 h of disease induction, animals were sacrificed to get tissues for histological evaluation and ulcer index was measured. While the antimicrobial potential of Lavandula stoechas L. aqueous and methanolic extracts was evaluated against different bacterial stains using standard antibiotic discs. Qualitative phytochemical and GCMS analysis were performed to identify novel constituents. Results: The methanolic extract of Lavandula stoechas L. showed antimicrobial activity against Proteus Mirabilis while the GCMS based analysis revealed the presence of 10 phytochemicals including camphor (antimicrobial agent). The aqueous extract showed significant anti-ulcer activity in ethanol-induced gastric (P < 0.001) and duodenal (P < 0.01) ulcers when compared with controls. Aqueous and methanolic Lavandula stoechas L. extracts showed strong free radical scavenging activity. Conclusion: Lavandula stoechas L. extract possess antimicrobial and anti-ulcer activity in alcohol-induced ulcer model in experimental animals.

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Section: Discussionsupporting

confidence: 92%

Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer

Javed

Khan

Arshad³

et al. 2020

RADS J. Pharm. Pharm. Sci.

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“…Such a lower response at higher dose could be due to 'therapeutic windows' effect of the extract [18]. The gastro-protective effect of Z. abyssinica root could be due to the presence of biological compounds such as flavonoids, alkaloids, tannins, saponins and other polyphenols present in extracts [19,20]. Alkaloids have been shown to possess gastroprotective and ulcer healing activity by inhibiting acid secretion and gastric motility, stimulation of mucus/bicarbonate secretion and increase mucosal blood flow [21].…”

Section: Discussionmentioning

confidence: 99%

Gastro-protective effect of Ziziphus abyssinica root extracts in ethanol-induced acute ulcer in Wistar rats

Yau

Abdulazeez

Anigo

et al. 2017

JAD

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“…Peptic ulcer disease (PUD) is one of the main illnesses and deaths around the globe. Mucosal lining erosions in the stomach and duodenum are its hallmarks (Majeed et al 2015 ). Histamine receptor blockers and proton pump inhibitors are the two most often used drugs to treat peptic ulcers.…”

Section: Gastroprotective Activitymentioning

confidence: 99%

Therapeutic potential of Lawsonia inermis Linn: a comprehensive overview

Batiha,

Teibo,

Shaheen

et al. 2023

Naunyn-Schmiedeberg's Arch Pharmacol

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Lawsonia inermis Linn, commonly known as henna, is a member of the Lythraceae family and has been found to contain a variety of compounds with both industrial and medicinal applications in its stem, bark, roots, flowers, and seeds. This report provides a comprehensive review of the bioactive components, pharmacological activities, pharmacokinetics, and pharmacological side effects of Lawsonia inermis. Relevant materials were gathered from Google Scholar, PubMed, Scopus, and Web of Science and reviewed for important properties and updates about the plant. Lawsonia inermis contains a variety of bioactive compounds, including flavonoids, coumarins, triterpenoids, steroids, xanthones, polyphenols, fatty acids, alkaloids, quinones, tannins, leucocyandin, epicatechin, catechin, and quercetin. The plant is been traditionally used to treat numerous conditions, including ulcers, bronchitis, lumbago, hemicrania, leukoderma, scabies, boils, ophthalmic disorders, hair loss, and jaundice. It has also been found to possess a range of pharmacological activities, including antioxidant, anti-inflammatory, analgesic, antiparasitic, hepatoprotective, antifungal, antitumor, wound healing, and hypoglycemic effects. The potential of Lawsonia inermis for various biological applications is promising, and further studies are needed to fully explore its therapeutic benefits for various diseases of public health. Concern advances in drug development could enable the characterization of various bioactive constituents and facilitate their development and application for the benefit of humanity.

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Medicinal plants with gastroprotective potential

Cited by 6 publications

References 62 publications

Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer

Pharmacological Evaluation of Lavandula stoechas L. for Ethanol-induced Gastric Mucosal Ulcer

Gastro-protective effect of Ziziphus abyssinica root extracts in ethanol-induced acute ulcer in Wistar rats

Therapeutic potential of Lawsonia inermis Linn: a comprehensive overview

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