Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Abstract

Abstract. Rhus tripartitum (sumac) is an Anacardiaceae tree with a wide phytotherapeutic application including the use of its roots in the management of gastric ulcer. In the present study the Rhus tripartitum root barks extract (RTE) was phytochemical studied, in vitro tested for their potential antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and reducing power assay and in vivo evaluated for its ability to prevent ethanol-induced gastric ulcer in rats. The RTE was rich in phenolics, flavonoids, tannins and polysaccharide contents and exhibited a low but not weak in vitro antioxidant activity when compared with (+)-catechin. Pre-treatment with RTE at oral doses 50, 200 and 400 mg/kg body weight was found to provide a dose-dependent protection against ethanolinduced ulcer by averting the deep ulcer lesions of the gastric epithelium, by reducing gastric juice and acid output, by enhancing gastric mucus production by preserving normal antioxidant enzymes activities, and inhibiting the lipid peroxidation. The antiulcerogenic activity of RTE might be due to a possible synergistic antioxidant and antisecretory effects.

Inter-species comparative antioxidant assay and HPTLC analysis of sakuranetin in the chloroform and ethanol extracts of aerial parts of Rhus retinorrhoea and Rhus tripartita

“…2004 , 2005 ; Alimi et al. 2013 ) which supports our findings of high-antioxidant property of RTEE. It was found that the sakuranetin content was more in RREE than RTEE.…”

Ethnobotanical study and phytochemical screening of six medicinal plants used in traditional medicine in the Northeastern Sahara of Algeria (area of Ouargla)

“…According to those surveyed for example S. tripartita (Anacardiaceae) known locally as "Djedari", aqueous decoction (67.96%), powder (16.50%) or infusion (15.53%) was considered as the most popular methods of preparation that can address several diseases such as digestive (F C = 66.90%), skin (F C = 11.27%) and circulatory (F C = 10.56%). Concerning the chemical studies of this plant, several compounds such as flavonoids, biflavonoids, isobiflavonoids, catechin, epicatechin-3-O-gallate, proanthocyanidin oligomers and polymers, polysaccharides, condensed tannins have been isolated from different parts of the plant (Tebourbi et al, 2006;Alimi et al, 2013). This plant has been used in Tunisian traditional medicine to treat diarrhoea and dysentery.…”

A combination of NMR and liquid chromatography to characterize the protective effects of Rhus tripartita extracts on ethanol-induced toxicity and inflammation on intestinal cells

“…Several plant extracts have been shown to have pharmacologic properties with applications to many disease models including EtOH-induced hepatotoxicity [8][9][10]. We have previously shown that treatment of rats with R. tripartita extracts provided a dose-dependent protection against EtOH-induced ulcer [11].…”

“…Plant extracts are multicomponent systems, and some have bioactive effects such as hepatoprotective and antioxidant properties in vivo against EtOH-induced toxicity [9,10]. For R. tripatita, we have previously shown that the root bark extract protects over EtOH-induced ulcer in rats, [11] while others demonstrated its antifungal and antibacterial properties [4,6].…”