Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models

Arun, Mehmet Zuhuri; Asha, V.V.

doi:10.1016/j.jep.2008.05.026

Cited by 64 publications

(46 citation statements)

References 29 publications

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“…The pathophysiology of these ulcers involves an imbalance between offensive (acid and pepsin) and defensive factors (mucin, prostaglandin and bicarbonate, etc.) (Arun and Asha 2008). The infection with Helicobacter pylori and the uses of non-steroid anti-inflammatory drugs (NSAIDs) are identified as promoters of gastric ulcer development (O'Malley 2003).…”

Section: Phytochemical Antioxidant and Protective Effect Of Rhus Trimentioning

confidence: 99%

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Alimi¹,

Mbarki²,

Barka³

et al. 2013

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Abstract. Rhus tripartitum (sumac) is an Anacardiaceae tree with a wide phytotherapeutic application including the use of its roots in the management of gastric ulcer. In the present study the Rhus tripartitum root barks extract (RTE) was phytochemical studied, in vitro tested for their potential antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) and reducing power assay and in vivo evaluated for its ability to prevent ethanol-induced gastric ulcer in rats. The RTE was rich in phenolics, flavonoids, tannins and polysaccharide contents and exhibited a low but not weak in vitro antioxidant activity when compared with (+)-catechin. Pre-treatment with RTE at oral doses 50, 200 and 400 mg/kg body weight was found to provide a dose-dependent protection against ethanolinduced ulcer by averting the deep ulcer lesions of the gastric epithelium, by reducing gastric juice and acid output, by enhancing gastric mucus production by preserving normal antioxidant enzymes activities, and inhibiting the lipid peroxidation. The antiulcerogenic activity of RTE might be due to a possible synergistic antioxidant and antisecretory effects.

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Section: Phytochemical Antioxidant and Protective Effect Of Rhus Trimentioning

confidence: 99%

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Alimi¹,

Mbarki²,

Barka³

et al. 2013

gpb

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“…Gastric mucosal injury was assessed semi-quantitatively using the previously described histopathological changes such as ulceration, hemorrhage, focal necrosis, mucosal congestion, glandular cell degeneration, infl ammation, and edema. Microscopic scoring of the tissue samples was performed on a scale ranging from 0 to 3 (0: None, 1: Mild, 2: Moderate, 3: Severe) (16,17). Histopathological score for each group was determined as the sum of the scores for each parameter (Tab.…”

Section: Histopathological Analysismentioning

confidence: 99%

Gastroprotective effects of CoQ10 on ethanol-induced acute gastric lesions

Karakaya¹,

Barut²,

Hancı³

et al. 2015

BLL

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Abstract:Introduction: Alcohol consumption is frequently associated with gastric mucosal lesions. The purpose of this study was to determine the effect of Coenzyme-Q 10 (CoQ 10 ) supplementation on the ethanol-induced gastric mucosal damage in a rat model. Material and method: Sixty-four female wistar albino rats were randomly divided into 8 groups (n = 8). Studies were performed in ethanol induced gastric ulcer model in Wistar albino rats. Famotidine at a dose of 5 mg/kg or 20 mg/kg and CoQ 10 at a single dose of 10 mg/kg or 20 mg/kg and 30 mg/kg for 7 days were administered as pretreatment. All the rats in study groups received 2 ml/kg ethanol 95 % intragastrically, 30 minutes after pretreatment. Four hour after ethanol administration, all rats were sacrifi ced and their stomachs were removed under ketamin anaesthesia. Gastric protection was evaluated by measuring the ulcer index, MDA concentrations, and histopathological studies. Results and discussion: Rats pretreated either with famotidine or CoQ 10 had signifi cantly diminished gastric mucosal damage which was assessed with gross and microscopic analysis (p < 0.00625). MDA levels were signifi cantly lower in famotidine 20 mg/kg and CoQ 10 pretreatment for 7 days group (p < 0.00625). Conclusion: CoQ 10 affords gastroprotection against ethanol-induced gastric mucosal lesions in rats especially after repetitive administrations (Tab. 3, Fig. 2, Ref. 35). Text in PDF www.elis.sk.

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“…This assay was carried out according to the method of Arun et al, (2008) [34] . The enzyme Catalase (CAT), catalyzes the conversion of H 2 O 2 into water.…”

Section: Assay Of Catalase (Cat)mentioning

confidence: 99%

Studies on gastroprotective activity of ethyl acetate leave fraction obtained from Canthium coromandelicum (Burm.f.) Alston in albino rats

Patro¹,

Sasmal²,

Mazumder³

et al. 2014

IOSRJPBS

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Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models

Cited by 64 publications

References 29 publications

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Gastroprotective effects of CoQ10 on ethanol-induced acute gastric lesions

Studies on gastroprotective activity of ethyl acetate leave fraction obtained from Canthium coromandelicum (Burm.f.) Alston in albino rats

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Gastroprotective effect of Dodonaea viscosa on various experimental ulcer models

Cited by 64 publications

References 29 publications

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Gastroprotective effects of CoQ10 on ethanol-induced acute gastric lesions

Studies on gastroprotective activity of ethyl acetate leave fraction obtained from Canthium coromandelicum (Burm.f.) Alston in albino rats

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Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats

Phytochemical, antioxidant and protective effect of Rhus tripartitum root bark extract against ethanol-induced ulcer in rats