2013
DOI: 10.5560/znc.2013.68c0097
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Gastroprotective Effect of an Ethanolic Extract from Neoglaziovia variegata (Arruda) Mez (Bromeliaceae) in Rats and Mice

Abstract: This study investigates the gastroprotective effect of a crude ethanolic extract of Neoglaziovia variegata (Arruda) Mez (Bromeliaceae), designated Nv-EtOH, in experimental models of gastric ulcer. In the ethanol-induced gastric ulcer model, Nv-EtOH showed gastroprotection at doses of 200 and 400 mg/kg body weight (BW) (57.0% and 79.7%, respectively). Nv-EtOH also significantly reduced the formation of gastric lesions induced by ethanol/HCl (31.6% and 63.5%), ibuprofen (70.0% and 74.3%), or ischemia/reperfusion… Show more

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Cited by 5 publications
(3 citation statements)
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“…N. variegata is used as a fiber plant by rural communities in the Caatinga region where a variety of products are made from the white, soft and flexible fibres (Almeida et al., 2008; Oliveira-Júnior et al., 2012; Silveira et al., 2010; Silveira et al., 2009). Ethanol extracts of N. variegata have been reported to be of low toxicity in vivo in mice (Lima-Saraiva et al., 2012), and to exhibit antinociceptive effect in experimental models in mice (Lima-Saraiva et al., 2012), photoprotective potential, antioxidant effect (Oliveira-Júnior et al., 2012; Lima-Saraiva et al., 2012), gastroprotective effects in a mice model of gastric ulcer (Machado et al., 2013) and antibacterial effect against both Gram-positive (Oliveira-Júnior et al., 2012) and Gram-negative bacteria (Oliveira-Júnior et al., 2012; Silva et al., 2014). Only limited information about the natural products of N. variegata is available in current literature.…”
Section: Introductionmentioning
confidence: 99%
“…N. variegata is used as a fiber plant by rural communities in the Caatinga region where a variety of products are made from the white, soft and flexible fibres (Almeida et al., 2008; Oliveira-Júnior et al., 2012; Silveira et al., 2010; Silveira et al., 2009). Ethanol extracts of N. variegata have been reported to be of low toxicity in vivo in mice (Lima-Saraiva et al., 2012), and to exhibit antinociceptive effect in experimental models in mice (Lima-Saraiva et al., 2012), photoprotective potential, antioxidant effect (Oliveira-Júnior et al., 2012; Lima-Saraiva et al., 2012), gastroprotective effects in a mice model of gastric ulcer (Machado et al., 2013) and antibacterial effect against both Gram-positive (Oliveira-Júnior et al., 2012) and Gram-negative bacteria (Oliveira-Júnior et al., 2012; Silva et al., 2014). Only limited information about the natural products of N. variegata is available in current literature.…”
Section: Introductionmentioning
confidence: 99%
“…N. variegata is used as a fiber plant by rural communities in the Caatinga region where a variety of products are made from the white, soft and flexible fibers [ 12 , 13 , 14 , 15 ]. Ethanol extracts of N. variegata have been reported to be of low toxicity [ 16 ] , and to exhibit antinociceptive effect in experimental models in mice [ 16 ], photoprotective potential, antioxidant effect [ 13 , 16 ], gastroprotective effects in a mice model of gastric ulcer [ 17 ] and antibacterial effect against both Gram-positive [ 13 ] and Gram-negative bacteria [ 13 , 18 ]. There is no report of natural products characterized from N. variegata .…”
Section: Introductionmentioning
confidence: 99%
“…N. variegata is an endemic Bromeliaceae, popularly known as “caroá,” widely distributed in the northeast region of Brazil. Previous studies have shown that this plant has antimicrobial [ 14 ], antinociceptive [ 15 ], gastroprotective [ 16 ], and antioxidant and photoprotective activities [ 17 , 18 ], probably related to the presence of phenolic and flavonoids. Despite its ethnopharmacological potential, the application of N. variegata extracts in sunscreens formulations remains unexplored, with no scientific reports or patent deposits (using Derwent World Patents Index database).…”
Section: Introductionmentioning
confidence: 99%