Gastrodin modified polyurethane conduit promotes nerve repair via optimizing Schwann cells function

Yang, Hongcai; Li, Qing; Li, Limei; Chen, Shaochun; Zhao, Yu; Hu, Yingrui; Wang, Lu; Lan, Xiaoqian; Zhong, Lianmei; Lü, Di

doi:10.1016/j.bioactmat.2021.06.020

Cited by 35 publications

(29 citation statements)

References 55 publications

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“…CREB promotes nerve cell survival, synaptic plasticity, and neurogenesis by increasing the expression of BDNF gene and antiapoptotic protein gene Bcl-2. Gastrodin has been proved to have the ability to repair axons in the peripheral nervous system [ 82 ]. In order to illustrate its role in the central system, relevant studies have shown that GAS can promote the reconstruction of peripheral nerve's microvascular network by reducing the expression of TNF- α and iNOS.…”

Section: Resultsmentioning

confidence: 99%

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Deng

Chen

Meng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Gastrodia elata, a traditional Chinese medicine, has been widely used since ancient times to treat diseases such as dizziness, epilepsy, stroke, and memory loss. Gastrodin, one of the active components of Gastrodia elata, has been used in the treatment of migraine, epilepsy, Parkinson’s disease, dementia, and depression in recent years. It can improve cognitive function and related neuropsychiatric symptoms through various effects and is considered as a promising treatment for dementia. Vascular dementia is a kind of severe cognitive impairment syndrome caused by vascular factors, and it is the dementia syndrome with the largest number of patients besides Alzheimer’s disease. Although there is still a lack of evidence-based explorations, the paper reviewed the mechanism and methods of gastrodin in the treatment of vascular dementia, providing a reference for clinical therapy.

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Section: Resultsmentioning

confidence: 99%

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Deng

Chen

Meng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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“…A drug-eluting NGC is another approach that has been taken to stimulate peripheral nerve regeneration. Yang et al 130 The studies reviewed here approached nerve regeneration with a variety of strategies, as one would expect given the complex biological and biomechanical cues that direct tissue regeneration in peripheral nerves. In vitro evidence, which has been reviewed at length elsewhere, supports the use of microstructurally aligned scaffolds, electrical stimulation, drug-loaded scaffolds, and pre-seeding with cells.…”

Section: Peripheral Nervementioning

confidence: 99%

“…A drug‐eluting NGC is another approach that has been taken to stimulate peripheral nerve regeneration. Yang et al 130 synthesized a PU incorporating a soft segment of PCL, hard segment of IPDI, and chain extender of l ‐lysine ethyl ester. The authors added 1 or 5 wt% of gastrodin to impart neuroprotective and angiogenic attributes before fabricating NGCs using salt leaching.…”

Section: Pre‐clinical Applications Of Biodegradable Pu Scaffoldsmentioning

confidence: 99%

Biodegradable polyurethane scaffolds in regenerative medicine: Clinical translation review

Pedersen

Kim

Wagner

2022

J Biomedical Materials Res

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Early explorations of tissue engineering and regenerative medicine concepts commonly utilized simple polyesters such as polyglycolide, polylactide, and their copolymers as scaffolds. These biomaterials were deemed clinically acceptable, readily accessible, and provided processability and a generally known biological response. With experience and refinement of approaches, greater control of material properties and integrated bioactivity has received emphasis and a broadened palette of synthetic biomaterials has been employed. Biodegradable polyurethanes (PUs) have emerged as an attractive option for synthetic scaffolds in a variety of tissue applications because of their flexibility in molecular design and ability to fulfill mechanical property objectives, particularly in soft tissue applications. Biodegradable PUs are highly customizable based on their composition and processability to impart tailored mechanical and degradation behavior. Additionally, bioactive agents can be readily incorporated into these scaffolds to drive a desired biological response. Enthusiasm for biodegradable PU scaffolds has soared in recent years, leading to rapid growth in the literature documenting novel PU chemistries, scaffold designs, mechanical properties, and aspects of biocompatibility. Despite the enthusiasm in the field, there are still few examples of biodegradable PU scaffolds that have achieved regulatory approval and routine clinical use. However, there is a growing literature where biodegradable PU scaffolds are being specifically developed for a wide range of pathologies and where relevant pre‐clinical models are being employed. The purpose of this review is first to highlight examples of clinically used biodegradable PU scaffolds, and then to summarize the growing body of reports on pre‐clinical applications of biodegradable PU scaffolds.

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“…16,17 Myriad strategies have been attempted to increase the cell adhesiveness of PU-based polymers for use in clinical settings. [18][19][20] The aromatic diisocyanates, which has an isocyanate (N C O) group directly attached to the aromatic ring, could improve the cell-adhesive functionalities when used in synthesizing PU polymers and enhance mechanical properties, [21][22][23][24][25][26] but the utilization of these materials in clinical settings is limited due to the low degradation rate and to tumorigenesis induced by degradation or unreacted monomers. 27,28 Instead, aliphatic diisocyanates has been introduced as a component of PU polymers due to its superior biocompatibility without toxic degradation byproducts, but they had compromised mechanical properties with moderate cell adhesiveness.…”

Section: Introductionmentioning

confidence: 99%

“…Myriad strategies have been attempted to increase the cell adhesiveness of PU‐based polymers for use in clinical settings 18–20 . The aromatic diisocyanates, which has an isocyanate (NCO) group directly attached to the aromatic ring, could improve the cell‐adhesive functionalities when used in synthesizing PU polymers and enhance mechanical properties, 21–26 but the utilization of these materials in clinical settings is limited due to the low degradation rate and to tumorigenesis induced by degradation or unreacted monomers 27,28 .…”

Section: Introductionmentioning

confidence: 99%

Hyperelastic, shape‐memorable, and ultra‐cell‐adhesive degradable polycaprolactone‐polyurethane copolymer for tissue regeneration

Hong

Yoon

Cha

et al. 2022

Bioengineering & Transla Med

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Novel polycaprolactone-based polyurethane (PCL-PU) copolymers with hyperelasticity, shape-memory, and ultra-cell-adhesion properties are reported as clinically applicable tissue-regenerative biomaterials. New isosorbide derivatives (propoxylated or ethoxylated ones) were developed to improve mechanical properties by enhanced reactivity in copolymer synthesis compared to the original isosorbide. Optimized PCL-PU with propoxylated isosorbide exhibited notable mechanical performance (50 MPa tensile strength and 1150% elongation with hyperelasticity under cyclic load). The shape-memory effect was also revealed in different forms (film, thread, and 3D scaffold) with 40%-80% recovery in tension or compression mode after plastic deformation. The ultra-cell-adhesive property was proven in various cell types which were reasoned to involve the heat shock protein-mediated integrin (α5 and αV) activation, as analyzed by RNA sequencing and inhibition tests. After the tissue regenerative potential (muscle and bone) was confirmed by the myogenic and osteogenic Suk-Min Hong, Ji-Young Yoon, and Jae-Ryung Cha contributed equally to this work.

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Gastrodin modified polyurethane conduit promotes nerve repair via optimizing Schwann cells function

Cited by 35 publications

References 55 publications

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Gastrodin and Vascular Dementia: Advances and Current Perspectives

Biodegradable polyurethane scaffolds in regenerative medicine: Clinical translation review

Hyperelastic, shape‐memorable, and ultra‐cell‐adhesive degradable polycaprolactone‐polyurethane copolymer for tissue regeneration

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