Gastrodin and Vascular Dementia: Advances and Current Perspectives

Abstract

Gastrodia elata, a traditional Chinese medicine, has been widely used since ancient times to treat diseases such as dizziness, epilepsy, stroke, and memory loss. Gastrodin, one of the active components of Gastrodia elata, has been used in the treatment of migraine, epilepsy, Parkinson’s disease, dementia, and depression in recent years. It can improve cognitive function and related neuropsychiatric symptoms through various effects and is considered as a promising treatment for dementia. Vascular dementia is a kind of severe cognitive impairment syndrome caused by vascular factors, and it is the dementia syndrome with the largest number of patients besides Alzheimer’s disease. Although there is still a lack of evidence-based explorations, the paper reviewed the mechanism and methods of gastrodin in the treatment of vascular dementia, providing a reference for clinical therapy.

The mechanism of microglia-mediated immune inflammation in ischemic stroke and the role of natural botanical components in regulating microglia: A review

“…Clinically, Gastrodia elata Bl. is generally used to treat vertebrobasilar insufficiency, vestibular neuritis and vertigo ( 193 ). Gastrodin is one of the main effective monomer components of Gastrodia elata Bl.…”

Post-stroke cognitive impairment and synaptic plasticity: A review about the mechanisms and Chinese herbal drugs strategies

“…Gastrodin the main active ingredient extracted from Rhizoma Gastrodiae has been widely applied in central nervous system disorders, and is a mature, sustainable industrial product used to treat vascular cognitive impairment (Deng et al, 2022). Gastrodin increases the activity of choline acetyltransferase, decreases the activity of acetylcholinesterase and glutamate, and regulates the brain cholinergic system after stroke (Zhang et al, 2008).…”

“…On the other hand, it can induce neural stem cell differentiation by regulating the cAMP/PKA/CREB signaling pathway (Ma et al, 2020). Furthermore, gastrodin can repair axons in the peripheral nervous system and to promote the growth of functional axons and myelin regeneration, and reconstruct the peripheral neural microvascular network (Deng et al, 2022;Yang et al, 2022).…”

Therapeutic Effects and Metabolic Spectrum of Traditional Chinese Medicine Hengqing II Prescription on Alzheimer’s Disease

“…Traditional Chinese medicine (TCM) is one of the most in uential alternative medicines in the world. Faced with the challenges of treating AD, TCM has gained importance in the prevention and treatment of AD, with a bright future [11][12][13][14]. To date, there is no theoretical basis for using TCM prescription to treat AD.…”