Gas-chromatographic determination of thiodiglycolic acid in urine using derivatization and liquid microextraction

Zhurba, O. M.; Alekseenko, A. N.

doi:10.1134/s106193481309013x

Cited by 3 publications

(2 citation statements)

References 6 publications

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“…Thus, the precise determination of TDGA is necessary. At present, there a variety of analytical techniques have been used to detect TDGA, such as gas chromatography [ 7 ], isokinetic electrophoresis [ 8 ], voltammetry [ 9 ] and liquid chromatography–mass spectrometry [ 10 ]. However, these methods are difficult to use for fast and real-time monitoring because of their complicated sample pretreatment, long processing time and inadequate detection limits [ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA

et al. 2022

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Thiodiglycolic acid (TDGA) is a biomarker for monitoring vinyl chloride exposure. Exploring a facile, rapid and precise analysis technology to quantify TDGA is of great significance. In this research, we demonstrate a fluorescent sensor based on dual-emissive UiO-66 for TDGA detection. This ratiometric fluorescent material named C460@Tb-UiO-66-(COOH)2 was designed and synthesized by introducing organic dye 7-diethylamino-4-methylcoumarin (C460) and Tb3+ into UiO-66-(COOH)2. The as-obtained C460@Tb-UiO-66-(COOH)2 samples showed highly selective recognition, excellent anti-interference and rapid response characteristics for the recognition of TDGA. The detection limit is 0.518 mg·mL−1, which is much lower than the threshold of 20 mg·mL−1 for a healthy person. In addition, the mechanism of TDGA-induced fluorescence quenching is discussed in detail. This sensor is expected to detect TDGA content in human urine.

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Section: Introductionmentioning

confidence: 99%

A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA

et al. 2022

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“…Thiodiglycolic acid (TDGA), the main metabolite of VCM in human urine, is taken as a sensitive biomarker in biological monitoring of VCM exposure, since there is a strong proportional correlation between the content of TDGA excreted in urine and the personal VCM exposure level. ,− Therefore, measurement of the urinary TDGA, as markers of internal dose, is an important way of assessing VCM exposure. To date, some methods such as gas chromatography (GC), GC-mass spectrography (GC-MS), , isotachophoresis, , voltammetry, capillary electrophoresis, and liquid chromatography-MS (LC-MS) have been well developed to detect TDGA.…”

Section: Introductionmentioning

confidence: 99%

A Luminescent 3d-4f-4d MOF Nanoprobe as a Diagnosis Platform for Human Occupational Exposure to Vinyl Chloride Carcinogen

Hao

Lian

et al. 2017

Inorg. Chem.

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A luminescent nanoprobe based on a lanthanide-transition heterometallic metal-organic framework (MOF) is first designed for specific detection of urinary thiodiglycolic acid (TDGA) which is the biomarker of carcinogenic vinyl chloride monomer (VCM) and represents the internal dose of human exposure to VCM. The nanoprobe demonstrates high selectivity to TDGA with about 27.5-fold luminescence enhancement. It also displays excellent sensitivity with a detection limit as low as 89 ng·mL and fast response to TDGA within 4 min, while refraining from the interference of other coexisting species in urine. Such good sensing performance enables the nanoprobe to practically monitor TDGA levels in human urine. Moreover, a portable urine dipstick based on the sensor is developed to conveniently evaluate individuals' intoxication degree of VCM. This fast, sensitive, and selective nanoprobe has promising potential to be a useful tool for point-of-care diagnosis of disease associated with VCM exposure.

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Microextraction in Urine Samples for Gas Chromatography: A Review

2014

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Since the complexity origin of biological samples, the research trends have been directed to the development of new miniaturized sample preparation techniques. This review provides a comprehensive survey of past and present microextraction methods followed by GC analysis for preconcentration and determination of various analytes in urine samples. These techniques have been classified in three general groups, including liquid-, solid- and membrane-based techniques. The principal of different microextraction methods that are located in each general group as well as their various extraction modes and the recent developments introduced for them has been presented. Subsequently, a comparison survey has been carried out among different microextraction techniques and finally a future perspective has been predicted based on the existing literature.

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Gas-chromatographic determination of thiodiglycolic acid in urine using derivatization and liquid microextraction

Cited by 3 publications

References 6 publications

A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA

A Ratiometric Fluorescent Sensor Based on Dye/Tb (III) Functionalized UiO-66 for Highly Sensitive Detection of TDGA

A Luminescent 3d-4f-4d MOF Nanoprobe as a Diagnosis Platform for Human Occupational Exposure to Vinyl Chloride Carcinogen

Microextraction in Urine Samples for Gas Chromatography: A Review

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