A Luminescent 3d-4f-4d MOF Nanoprobe as a Diagnosis Platform for Human Occupational Exposure to Vinyl Chloride Carcinogen

Hao, Ji‐Na; Xu, Xiaoyu; Lian, Xiao; Zhang, Chi; Yan, Bing

doi:10.1021/acs.inorgchem.7b01549

Cited by 52 publications

(20 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some MOFs have extra-large surface areas, high-connectivity polyhedral cages, large pore volumes, high stability, nontoxicity, biocompatibility, and small sizes, making them potential excellent nanocarriers in the biomedical field [ 38 ]. These nanomedical materials can be used for various purposes, such as imaging agents for early and minimally invasive diagnosis, for specific cell and tissue (more commonly used in tumor tissue) targeting, entrapping high loadings of a drug, increased drug concentration in a local site, and creating drug-delivery formulations [ 39 , 40 , 41 ]. For example, Gordon, using an incipient wetness impregnation method, successfully loaded three model drugs (acetaminophen, progesterone, and stavudine) into MIL-53(Fe), MIL-101, and SBA-15 (20 wt %).…”

Section: Discussionmentioning

confidence: 99%

Biocompatible Fe-Based Micropore Metal-Organic Frameworks as Sustained-Release Anticancer Drug Carriers

et al. 2018

View full text Add to dashboard Cite

Sustained-release preparation is a hot spot in antitumor drug research, where the first task is to select suitable drug carriers. Research has revealed that carboxylic acid iron metal–organic frameworks (MOFs), constructed from iron (Fe) ions and terephthalic acid, are nontoxic and biocompatible. Due to the breathing effect, the skeleton of this mesoporous material is flexible and can reversibly adapt its pore size through drug adsorption. Therefore, we chose one kind of Fe-MOF, MIL-53(Fe), as a carrier for the anticancer drug oridonin (Ori). In this work, we report the design and synthesis of MIL-53(Fe) and explore its ability as a transport vehicle to deliver Ori. MIL-53(Fe) is characterized by scanning electron microscopy and X-ray powder diffraction. A loading capacity of 56.25 wt % was measured by high performance liquid chromatography. This carrier was safe and nontoxic (cell viability > 95.27%), depending on the results of 3-(4,5-dimethylthiazol-2-yl)--2,5-diphenyltetrazolium bromide assays, lactate dehydrogenase assays, and Annexin V-fluoresce isothiocyanate/propidium iodide double-staining assays. After loading the drug, the structure of the MIL-53(Fe) was not destroyed, and Ori was amorphous in MIL-53(Fe). Based on an analysis of the Ori release profile, results suggest that it lasts for more than seven days in vitro. The cumulative release rate of Ori at the seventh day was about 82.23% and 91.75% in phosphate buffer saline solution at 37 °C under pH 7.2 and pH 5.5, respectively. HepG2 cells were chosen to study the cytotoxicity of Ori@MIL-53(Fe), and the results show that the anticancer ratio of Ori@MIL-53(Fe) system reaches 90.62%. Thus, MIL-53 can be used as a carrier for anticancer drugs and Ori@MIL-53(Fe) is a promising sustained-release drug delivery system for the cancer therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Biocompatible Fe-Based Micropore Metal-Organic Frameworks as Sustained-Release Anticancer Drug Carriers

et al. 2018

View full text Add to dashboard Cite

show abstract

“…MOF‐based luminescent materials can be designed for the detection of target chemicals, such as vinyl chloride carcinogen and explosives . By adjusting the degree of functionalization and pore volumes of MOFs, the luminescent response can be efficiently altered for industrial purposes.…”

Section: Applicationsmentioning

confidence: 99%

Mesoporous Metal–Organic Frameworks: Synthetic Strategies and Emerging Applications

Liu

Zou

Zhu

et al. 2018

Small

150

117

View full text Add to dashboard Cite

Metal-organic frameworks (MOFs) have attracted much attention over the past two decades due to their highly promising applications not only in the fields of gas storage, separation, catalysis, drug delivery, and sensors, but also in relatively new fields such as electric, magnetic, and optical materials resulting from their extremely high surface areas, open channels and large pore cavities compared with traditional porous materials like carbon and inorganic zeolites. Particularly, MOFs involving pores within the mesoscopic scale possess unique textural properties, leading to a series of research in the design and applications of mesoporous MOFs. Unlike previous Reviews, apart from focusing on recent advances in the synthetic routes, unique characteristics and applications of mesoporous MOFs, this Review also mentions the derivatives, composites, and hierarchical MOF-based systems that contain mesoporosity, and technical boundaries and challenges brought by the drawbacks of mesoporosity. Moreover, this Review subsequently reveals promising perspectives of how recently discovered approaches to different morphologies of MOFs (not necessarily entirely mesoporous) and their corresponding performances can be extended to minimize the shortcomings of mesoporosity, thus providing a wider and brighter scope of future research into mesoporous MOFs, but not just limited to the finite progress in the target substances alone.

show abstract

“…Yan and coworkers were the first to design a diagnosis platform for vinyl chloride carcinogen based on a 3d–4f–4d heterometallic MOF (Eu 3+ /Cu 2+ -Zr 6 O 4 (OH) 4 (O 2 C-C 6 H 2 -CO 2 (CO 2 H) 2 ) 6 · x H 2 O) [ 128 ]. The nanoprobe exhibits high selectivity to thiodiglycolic acid (TDGA) with a luminescence enhancement of about 27.5-fold, the main metabolite of vinyl chloride monomer (VCM) in human urine.…”

Section: Lnmofs For Chemical Sensingmentioning

confidence: 99%

Luminescent Lanthanide MOFs: A Unique Platform for Chemical Sensing

et al. 2018

View full text Add to dashboard Cite

In recent years, lanthanide metal–organic frameworks (LnMOFs) have developed to be an interesting subclass of MOFs. The combination of the characteristic luminescent properties of Ln ions with the intriguing topological structures of MOFs opens up promising possibilities for the design of LnMOF-based chemical sensors. In this review, we present the most recent developments of LnMOFs as chemical sensors by briefly introducing the general luminescence features of LnMOFs, followed by a comprehensive investigation of the applications of LnMOF sensors for cations, anions, small molecules, nitroaromatic explosives, gases, vapors, pH, and temperature, as well as biomolecules.

show abstract

A Luminescent 3d-4f-4d MOF Nanoprobe as a Diagnosis Platform for Human Occupational Exposure to Vinyl Chloride Carcinogen

Cited by 52 publications

References 53 publications

Biocompatible Fe-Based Micropore Metal-Organic Frameworks as Sustained-Release Anticancer Drug Carriers

Biocompatible Fe-Based Micropore Metal-Organic Frameworks as Sustained-Release Anticancer Drug Carriers

Mesoporous Metal–Organic Frameworks: Synthetic Strategies and Emerging Applications

Luminescent Lanthanide MOFs: A Unique Platform for Chemical Sensing

Contact Info

Product

Resources

About