GAMOS: An easy and flexible way to use GEANT4

Arce, P.; Lagáres, J.I.; Harkness, L. J.; Desorgher, L.; Lorenzo, G. De; Abreu, Y.; Wang, Zhentian

doi:10.1109/nssmic.2011.6154455

Cited by 22 publications

(24 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Simulations made with GAMOS [14] show that ∼ 2/3 of the events with energy below 350 keV have scattered outside the detector and are detected afterwards, the remaining events are due to photons that underwent a Compton scattering inside the diode before escaping.…”

Section: Resultsmentioning

confidence: 99%

Energy and coincidence time resolution measurements of CdTe detectors for PET

et al. 2013

View full text Add to dashboard Cite

We report on the characterization of 2 mm thick CdTe diode detector with Schottky contacts to be employed in a novel conceptual design of PET scanner. Results at -8 • C with an applied bias voltage of -1000 V/mm show a 1.2% FWHM energy resolution at 511 keV. Coincidence time resolution has been measured by triggering on the preamplifier output signal to improve the timing resolution of the detector. Results at the same bias and temperature conditions show a FWHM of 6 ns with a minimum acceptance energy of 500 keV.These results show that pixelated CdTe Schottky diode is an excellent candidate for the development of next generation nuclear medical imaging devices such as PET, Compton gamma cameras, and especially PET-MRI hybrid systems when used in a magnetic field immune configuration.

show abstract

Section: Resultsmentioning

confidence: 99%

Energy and coincidence time resolution measurements of CdTe detectors for PET

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Unlike traditional fluorescence tomography measurements, where excitation is done with a laser entering the medium at the surface, our fluorophore was excited by Čerenkov radiation, which was generated throughout the interior of the phantom. To approximate the excitation field, distribution and photon intensity, Monte Carlo modeling was performed using GAMOS [10, 11]. The resultant field calculations were interpolated onto our mesh and used in the diffusion forward model, see Figure 3a.…”

mentioning

confidence: 99%

Čerenkov excited fluorescence tomography using external beam radiation

Demers¹,

Davis²,

Zhang³

et al. 2013

Opt. Lett.

View full text Add to dashboard Cite

Radiation treatment of cancer induces an optical Čerenkov emission throughout the treated volume, which could be used to excite molecular reporters in vivo, allowing molecular sensing of tissue response during fractionated therapy. In this letter, the idea that spatial mapping of this signal can be achieved with tomographic recovery of the fluorophore distribution is tested for the first time, using 6 MeV photons from a linear accelerator in a heterogeneous tissue phantom. Čerenkov light excited fluorophore throughout the tissue phantom, and diffuse tomography was used to recover images. Measurements from13 locations were used, with spectrometer detection and spectral fitting, to separate the fluorophore emission from the Čerenkov continuum. Fluorescent diffuse tomographic images showed a linear response between the concentration and the reconstructed values. The potential to apply this molecular imaging in treatment with molecular reporters appears promising.

show abstract

“…2) (34, 35). The gamma ray excitation profiles and subsequent Cherenkov photons were simulated using GAMOS, a Geant4-based Monte Carlo toolbox (48,49). For the purposes of this simulation, the phantom was discretized into a set of uniform voxels with an edge size of 0.2 mm and modeled using water-equivalent energy response values in GAMOS.…”

Section: Phantom Experimentsmentioning

confidence: 99%

Cherenkov excited phosphorescence-based pO₂estimation during multi-beam radiation therapy: phantom and simulation studies

Holt¹,

Zhang²,

Esipova³

et al. 2014

Phys. Med. Biol.

View full text Add to dashboard Cite

Megavoltage radiation beams used in External Beam Radiotherapy (EBRT) generate Cherenkov light emission in tissues and equivalent phantoms. This optical emission was utilized to excite an oxygen-sensitive phosphorescent probe, PtG4, which has been developed specifically for NIR lifetime-based sensing of the partial pressure of oxygen (pO2). Phosphorescence emission, at different time points with respect to the excitation pulse, was acquired by an intensifier-gated CCD camera synchronized with radiation pulses delivered by a medical linear accelerator. The pO2 distribution was tomographically recovered in a tissue-equivalent phantom during EBRT with multiple beams targeted from different angles at a tumor-like anomaly. The reconstructions were tested in two different phantoms that have fully oxygenated background, to compare a fully oxygenated and a fully deoxygenated inclusion. To simulate a realistic situation of EBRT, where the size and location of the tumor is well known, spatial information of a prescribed region was utilized in the recovery estimation. The phantom results show that region-averaged pO2 values were recovered successfully, differentiating aerated and deoxygenated inclusions. Finally, a simulation study was performed showing that pO2 in human brain tumors can be measured to within 15mmHg for edge depths less than 10-20mm using the Cherenkov Excited Phosphorescence Oxygen imaging (CEPhOx) method and PtG4 as a probe. This technique could allow non-invasive monitoring of pO2 in tumors during the normal process of EBRT, where beams are generally delivered from multiple angles or arcs during each treatment fraction.

show abstract

GAMOS: An easy and flexible way to use GEANT4

Cited by 22 publications

References 19 publications

Energy and coincidence time resolution measurements of CdTe detectors for PET

Energy and coincidence time resolution measurements of CdTe detectors for PET

Čerenkov excited fluorescence tomography using external beam radiation

Cherenkov excited phosphorescence-based pO₂estimation during multi-beam radiation therapy: phantom and simulation studies

Contact Info

Product

Resources

About

GAMOS: An easy and flexible way to use GEANT4

Cited by 22 publications

References 19 publications

Energy and coincidence time resolution measurements of CdTe detectors for PET

Energy and coincidence time resolution measurements of CdTe detectors for PET

Čerenkov excited fluorescence tomography using external beam radiation

Cherenkov excited phosphorescence-based pO2estimation during multi-beam radiation therapy: phantom and simulation studies

Contact Info

Product

Resources

About

Cherenkov excited phosphorescence-based pO₂estimation during multi-beam radiation therapy: phantom and simulation studies