Čerenkov excited fluorescence tomography using external beam radiation

Demers, Jennifer-Lynn H.; Davis, Scott C.; Zhang, Rongxiao; Gladstone, David J.; Pogue, Brian W.

doi:10.1364/ol.38.001364

Cited by 35 publications

(36 citation statements)

References 17 publications

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“…Č erenkov radiation has been the subject of considerable research in recent years for potential applications in life sciences and engineering. A number of articles have appeared introducing its potential applications in molecular imaging, [12][13][14][15][16][17][18][19] monitoring of tissue optical properties, 20 ionizing radiation beam monitoring, quality assurance and dosimetry, [21][22][23][24][25][26][27][28][29][30][31][32][33] and particle detection. [34][35][36][37][38] When optical fibers pass through ionizing radiation fields of high energy, as in fiber-optic dosimetry, Č erenkov radiation generated inside the fibers' core is guided through the fiber if the emitted ray hits the core-cladding boundary with an angle greater than the critical angle satisfying the total internal reflection condition required for guided rays.…”

Section: Introductionmentioning

confidence: 99%

Spectroscopic separation of Čerenkov radiation in high-resolution radiation fiber dosimeters

et al. 2015

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Abstract. We have investigated Č erenkov radiation generated in phosphor-based optical fiber dosimeters irradiated with clinical electron beams. We fabricated two high-spatial resolution fiber-optic probes, with 200 and 400 μm core diameters, composed of terbium-based phosphor tips. A generalizable spectroscopic method was used to separate Č erenkov radiation from the transmitted signal by the fiber based on the assumption that the recorded signal is a linear superposition of two basis spectra: characteristic luminescence of the phosphor medium and Č erenkov radiation. We performed Monte Carlo simulations of the Č erenkov radiation generated in the fiber and found a strong dependence of the recorded Č erenkov radiation on the numerical aperture of the fiber at shallow phantom depths; however, beyond the depth of maximum dose that dependency is minimal. The simulation results agree with the experimental results for Č erenkov radiation generated in fibers. The spectroscopic technique used in this work can be used for development of high-spatial resolution fiber micro dosimeters and for optical characterization of various scintillating materials, such as phosphor nanoparticles, in ionizing radiation fields of high energy. © The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.

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Section: Introductionmentioning

confidence: 99%

Spectroscopic separation of Čerenkov radiation in high-resolution radiation fiber dosimeters

et al. 2015

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“…Čerenkov radiation has been the subject of considerable research in recent years for potential applications in life sciences and engineering.A number of articles has appeared introducing its potential application in molecular imaging [10][11][12][13][14][15][16][17][18], monitoring of tissue optical properties [19], ionizing radiation beam monitoring, quality assurance, and dosimetry [20][21][22][23][24][25][26][27][28][29][30][31], and particle detection [32][33][34][35][36].When optical fibers pass through ionizing radiation fields of high energy, as in fiber optic dosimetry, Čerenkov radiation generated inside the fibers' core is guided through the fiber if the emitted ray hits the core-cladding boundary with an angle greater than the critical angle satisfying total internal reflection condition required for guided rays. Transmission of Čerenkov radiation is, therefore, dependent on the angle between the particle's track and the fiber's axis.Therefore, the recorded raw signal is not directly related to the absorbed dose by the scintillator.…”

Section: Introductionmentioning

confidence: 99%

Separation of Čerenkov radiation in irradiated optical fibers by optical spectroscopy

Darafsheh¹,

Zhang

Kanick

et al. 2015

SPIE Proceedings

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We studied Čerenkov radiation generated in irradiated optical fibers and demonstrated a generic spectroscopic method for separation of Čerenkov radiation from the transmitted signal in fiber optic dosimetry based on the assumption that the recorded signal is a linear superposition of two basis spectra: Čerenkov radiation and characteristic luminescence of the phosphor medium. Experimentally, we evaluated thistechnique by using fiber optic probes irradiated by electron beams generated by a clinical linear accelerator. This method can be used for optical characterization of various scintillating materials, such as phosphor nanoparticles, in ionizing radiation fields of high energy. We performed MonteCarlo simulations of the Čerenkov radiation generated in the fiber and found astrong dependence of the recorded Čerenkov radiation on the numerical aperture of the fiber at shallow phantom depths; however, beyond the depth of maximum dose that dependency is minimal. Oursimulation results agree well withthe experimental results for Čerenkov radiation generated in fibers irradiated with 6 MeV electrons.

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“…When we deal with organs with the same density but different radiotracer uptakes, their anatomical imaging may be invalid; however, Cerenkov imaging can be used to distinguish them. Cerenkov imaging can be divided into two types: Cerenkov luminescence imaging (CLI) [6][7][8][9][10][11][12][13][14][15][16] and Cerenkov luminescence tomography (CLT) [17][18][19][20][21][22][23][24][25][26]. CLI is a type of 2D planar imaging, whereas CLT was developed to reconstruct the 3D distribution of radiotracers inside a living animal.…”

Section: Introductionmentioning

confidence: 99%

“…A solution to the inverse problem can generally be divided into two types. One is a statistical method, e.g., a Monte Carlo [26,27] or Bayesian [28,29] method. The other is optimization using a least-squares criterion [18,19,30,31], a regularization method [18][19][20][21][22][23], a level set method [32,33], etc.…”

Section: Introductionmentioning

confidence: 99%

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Probability method for Cerenkov luminescence tomography based on conformance error minimization

Ding¹,

Wang²,

Jie³

et al. 2014

Biomed. Opt. Express

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Cerenkov luminescence tomography (CLT) was developed to reconstruct a three-dimensional (3D) distribution of radioactive probes inside a living animal. Reconstruction methods are generally performed within a unique framework by searching for the optimum solution. However, the ill-posed aspect of the inverse problem usually results in the reconstruction being non-robust. In addition, the reconstructed result may not match reality since the difference between the highest and lowest uptakes of the resulting radiotracers may be considerably large, therefore the biological significance is lost. In this paper, based on the minimization of a conformance error, a probability method is proposed that consists of qualitative and quantitative modules. The proposed method first pinpoints the organ that contains the light source. Next, we developed a 0-1 linear optimization subject to a space constraint to model the CLT inverse problem, which was transformed into a forward problem by employing a region growing method to solve the optimization. After running through all of the elements used to grow the sources, a source sequence was obtained. Finally, the probability of each discrete node being the light source inside the organ was reconstructed. One numerical study and two in vivo experiments were conducted to verify the performance of the proposed algorithm, and comparisons were carried out using the hp-finite element method (hp-FEM). The results suggested that our proposed probability method was more robust and reasonable than hp-FEM.

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Čerenkov excited fluorescence tomography using external beam radiation

Cited by 35 publications

References 17 publications

Spectroscopic separation of Čerenkov radiation in high-resolution radiation fiber dosimeters

Spectroscopic separation of Čerenkov radiation in high-resolution radiation fiber dosimeters

Separation of Čerenkov radiation in irradiated optical fibers by optical spectroscopy

Probability method for Cerenkov luminescence tomography based on conformance error minimization

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