Gallic acid attenuates pulmonary fibrosis in a mouse model of transverse aortic contraction-induced heart failure

Jin, Li; Piao, Zhe; Sun, Simei; Liu, Bin; Ryu, Yuhee; Choi, Sin Young; Kim, Gwi Ran; Kim, Hyung-Seok; Kee, Hae Jin; Cho, Jeong Gwan

doi:10.1016/j.vph.2017.10.007

Cited by 18 publications

(16 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Gallic acid (GA) is a potent antioxidant discovered in plants and many fruits and is beneficial in inhibiting metastasis in glioma [128], gastric [129], and prostate cancer cells [130]. Some reports showed that GA shows efficacy against EMT-related markers, and it is a potential therapeutic agent in pulmonary fibrosis in mice [131].…”

Section: Gallic Acidmentioning

confidence: 99%

Nanomaterials as Inhibitors of Epithelial Mesenchymal Transition in Cancer Treatment

Cordani

Strippoli

Somoza

2019

Cancers

View full text Add to dashboard Cite

Epithelial-mesenchymal transition (EMT) has emerged as a key regulator of cell invasion and metastasis in cancers. Besides the acquisition of migratory/invasive abilities, the EMT process is tightly connected with the generation of cancer stem cells (CSCs), thus contributing to chemoresistance. However, although EMT represents a relevant therapeutic target for cancer treatment, its application in the clinic is still limited due to various reasons, including tumor-stage heterogeneity, molecular-cellular target specificity, and appropriate drug delivery. Concerning this last point, different nanomaterials may be used to counteract EMT induction, providing novel therapeutic tools against many different cancers. In this review, (1) we discuss the application of various nanomaterials for EMT-based therapies in cancer, (2) we summarize the therapeutic relevance of some of the proposed EMT targets, and (3) we review the potential benefits and weaknesses of each approach.

show abstract

Section: Gallic Acidmentioning

confidence: 99%

Nanomaterials as Inhibitors of Epithelial Mesenchymal Transition in Cancer Treatment

Cordani

Strippoli

Somoza

2019

Cancers

View full text Add to dashboard Cite

show abstract

“…GA has been attributed a wide range of biological effects, including antioxidant, anti-inflammatory, antimicrobial, and antitumor (Farhoosh & Nyström, 2018;Rajan & Muraleedharan, 2017;Yao et al, 2017). In addition, the effect of GA on the reduction of chronic degenerative diseases such as diabetes (Abdel-Moneim, El-Twab, Yousef, Reheim, & Ashour, 2018;Abdel-Moneim, Yousef, El-Twab, Reheim, & Ashour, 2017), obesity (Huang, Chang, Yang, Wu, & Shen, 2018), heart disease (Jin, Piao et al, 2017;Jin, Sun et al, 2018), and cancer (Liao, Chen, Huang, & Wang, 2018;Sales et al, 2018) has been studied. However, GA exhibits poor stability at high temperatures, in oxygen, in light, and in alkaline pH, in addition to its low absorption after oral administration (Acevedo et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Tapia-Hernández

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

View full text Add to dashboard Cite

Currently, electrospraying is a novel process for obtaining the nanoparticles from biopolymers. Zein nanoparticles have been obtained by this method and used to protect both hydrophilic and hydrophobic antioxidant molecules from environmental factors. The objective of this work was to prepare and characterize gallic acid‐loaded zein nanoparticles obtained by the electrospraying process to provide protection to gallic acid from environmental factors. Thus, it was related to the concentration of gallic acid in physicochemical and rheological properties of the electrosprayed solution, and also to equipment parameters, such as voltage, flow rate, and distance of the collector in morphology, and particle size. The physicochemical properties showed a relationship in the formation of a Taylor cone, in which at a low concentration of gallic acid (1% w/v), low viscosity (0.00464 ± 0.00001 Pa·s), and density (0.886 ± 0.00002 g/cm3), as well as high electrical conductivity (369 ± 4.3 µs/cm), forms a stable cone‐jet mode. The rheological properties and the Power Law model of the gallic acid‐zein electrosprayed solution demonstrated Newtonian behavior (n = 1). The morphology and size of the particle were dependent on the concentration of gallic acid. Electrosprayed parameters with high voltage (15 kV), low flow rate (0.1 mL/hr), and short distance (10 cm) exhibited a smaller diameter and spherical morphology. FT–IR showed interaction in the gallic acid‐loaded zein nanoparticle by hydrogen bonds. Therefore, the electrospraying process is a feasible technique for obtaining gallic acid‐loaded zein nanoparticles and providing potential protection to gallic acid from environmental factors.

show abstract

“…Recently, we reported that gallic acid attenuates pulmonary fibrosis in a mouse model of TAC-induced heart failure 17 . In the present study, gallic acid significantly reduced the levels of heart failure markers including ANP, BNP, skeletal α-actin, and β-MHC in the hearts of mice in the TAC group.…”

Section: Discussionmentioning

confidence: 99%

“…Gallic acid, losartan, carvedilol, and furosemide were dissolved in DMSO. The dosage of gallic acid (100 mg/kg/day) used for in vivo experiments was chosen because of the lack of toxicity and tolerable concentration in previous studies 14 , 15 , 17 , 18 . After drug administration for 2 weeks, the mice were sacrificed.…”

Section: Methodsmentioning

confidence: 99%

Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure

Jin

Sun

Ryu

et al. 2018

Sci Rep

Self Cite

View full text Add to dashboard Cite

Gallic acid is a trihydroxybenzoic acid found in tea leaves and some plants. Here, we report the effect of gallic acid on cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure and in primary rat cardiac fibroblasts, and compare the effects of gallic acid with those of drugs used in clinics. Gallic acid reduces cardiac hypertrophy, dysfunction, and fibrosis induced by transverse aortic constriction (TAC) stimuli in vivo and transforming growth factor β1 (TGF-β1) in vitro. It decreases left ventricular end-diastolic and end-systolic diameter, and recovers the reduced fractional shortening in TAC. In addition, it suppresses the expression of atrial natriuretic peptide, brain natriuretic peptide, skeletal α-actin, and β-myosin heavy chain. Administration of gallic acid decreases perivascular fibrosis, as determined by Trichrome II Blue staining, and reduces the expression of collagen type I and connective tissue growth factor. However, administration of losartan, carvedilol, and furosemide does not reduce cardiac dysfunction and fibrosis in TAC. Moreover, treatment with gallic acid inhibits fibrosis-related genes and deposition of collagen type I in TGF-β1-treated cardiac fibroblasts. These results suggest that gallic acid is a therapeutic agent for cardiac dysfunction and fibrosis in chronic heart failure.

show abstract

Gallic acid attenuates pulmonary fibrosis in a mouse model of transverse aortic contraction-induced heart failure

Cited by 18 publications

References 42 publications

Nanomaterials as Inhibitors of Epithelial Mesenchymal Transition in Cancer Treatment

Nanomaterials as Inhibitors of Epithelial Mesenchymal Transition in Cancer Treatment

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure

Contact Info

Product

Resources

About