Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure

Jin, Li; Sun, Simei; Ryu, Yuhee; Piao, Zhe; Liu, Bin; Choi, Sin Young; Kim, Gwi Ran; Kim, Hyung-Seok; Kee, Hae Jin; Cho, Jeong Gwan

doi:10.1038/s41598-018-27599-4

Cited by 61 publications

(42 citation statements)

References 40 publications

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“…Cardiac hypertrophy is an important characteristic of many cardiovascular diseases; it usually results in heart failure and is a major cause of mortality worldwide [1]. Cardiac hypertrophy results in myocardial adverse remodeling, which includes myocardial fibrosis, cardiomyocyte death, and cardiac dysfunction [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Wnt-C59 Attenuates Pressure Overload-Induced Cardiac Hypertrophy via Interruption of Wnt Pathway

Zhao

Liu

et al. 2020

Med Sci Monit

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Departmental sources Background: Cardiac hypertrophy usually results in heart failure and is an important cause of mortality worldwide. Wnt/bcatenin signaling pathway hyper-activation is involved in the pathogenesis and progression of cardiac hypertrophy. Wnt-C59 is a small molecular compound, which strongly and specifically targets at Porcupine to pharmacologically inhibit Wnt palmitoylation, secretion, and other biological activities. However, the role of Wnt-C59 in cardiac hypertrophy remains unknown. Material/Methods: We performed transverse aortic constriction (TAC) in adult male mice to induce pressure overload and establish an in vivo model of cardiac hypertrophy. Angiotensin II (Ang-II) was utilized to culture cardiomyocyte to establish a model of in vitro cardiomyocyte hypertrophy. Daily administration of Porcupine inhibitor Wnt-C59 was performed for 4 weeks after TAC surgery. Results: Wnt-C59 significantly improved cardiac function and enhanced survival of mice subjected to TAC surgery. Histologically, Wnt-C59 attenuated TAC-induced increase in heart mass, cross-section area of cardiomyocyte, cardiac fibrosis, cardiomyocyte apoptosis, and expression of the hypertrophic biomarkers b-MHC, ANP, and BNP. TAC-induced oxidative stress was also ameliorated by Wnt-C59. Wnt-C59 attenuated Ang-II-induced in vitro cardiomyocyte hypertrophy, as indicated by decreased cell size and lower expression of ANP, BNP, and b-MHC. Moreover, Wnt/b-catenin activation was blocked by Wnt-C59 in cardiac hypertrophy, as indicated by decreased protein expression of Wnt3a and b-catenin and the Wnt target genes cyclin D1 and c-Myc. Conclusions: Collectively, Porcupine inhibitor Wnt-C59 attenuates pressure overload-induced cardiac hypertrophic via interruption of the Wnt/b-catenin signaling pathway, and it might be a promising drug for patients with cardiac hypertrophy.

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Section: Introductionmentioning

confidence: 99%

Wnt-C59 Attenuates Pressure Overload-Induced Cardiac Hypertrophy via Interruption of Wnt Pathway

Zhao

Liu

et al. 2020

Med Sci Monit

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“…GA has been attributed a wide range of biological effects, including antioxidant, anti-inflammatory, antimicrobial, and antitumor (Farhoosh & Nyström, 2018;Rajan & Muraleedharan, 2017;Yao et al, 2017). In addition, the effect of GA on the reduction of chronic degenerative diseases such as diabetes (Abdel-Moneim, El-Twab, Yousef, Reheim, & Ashour, 2018;Abdel-Moneim, Yousef, El-Twab, Reheim, & Ashour, 2017), obesity (Huang, Chang, Yang, Wu, & Shen, 2018), heart disease (Jin, Piao et al, 2017;Jin, Sun et al, 2018), and cancer (Liao, Chen, Huang, & Wang, 2018;Sales et al, 2018) has been studied. However, GA exhibits poor stability at high temperatures, in oxygen, in light, and in alkaline pH, in addition to its low absorption after oral administration (Acevedo et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Tapia-Hernández

Del‐Toro‐Sánchez

Cinco-Moroyoqui

et al. 2019

Journal of Food Science

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Currently, electrospraying is a novel process for obtaining the nanoparticles from biopolymers. Zein nanoparticles have been obtained by this method and used to protect both hydrophilic and hydrophobic antioxidant molecules from environmental factors. The objective of this work was to prepare and characterize gallic acid‐loaded zein nanoparticles obtained by the electrospraying process to provide protection to gallic acid from environmental factors. Thus, it was related to the concentration of gallic acid in physicochemical and rheological properties of the electrosprayed solution, and also to equipment parameters, such as voltage, flow rate, and distance of the collector in morphology, and particle size. The physicochemical properties showed a relationship in the formation of a Taylor cone, in which at a low concentration of gallic acid (1% w/v), low viscosity (0.00464 ± 0.00001 Pa·s), and density (0.886 ± 0.00002 g/cm3), as well as high electrical conductivity (369 ± 4.3 µs/cm), forms a stable cone‐jet mode. The rheological properties and the Power Law model of the gallic acid‐zein electrosprayed solution demonstrated Newtonian behavior (n = 1). The morphology and size of the particle were dependent on the concentration of gallic acid. Electrosprayed parameters with high voltage (15 kV), low flow rate (0.1 mL/hr), and short distance (10 cm) exhibited a smaller diameter and spherical morphology. FT–IR showed interaction in the gallic acid‐loaded zein nanoparticle by hydrogen bonds. Therefore, the electrospraying process is a feasible technique for obtaining gallic acid‐loaded zein nanoparticles and providing potential protection to gallic acid from environmental factors.

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“…This importance of this compound in cardiovascular protection has also been demonstrated in other experimental models. Jin et al [72], for example, observed that 7 also had positive effects on cardiac dysfunction and fibrosis in a mouse model of pressure overload-induced heart failure, demonstrating its potential as therapeutic agent for cardiac dysfunction and fibrosis in chronic heart failure. Jin et al…”

Section: Isolated Compounds From Brazilian Medicinal Plants With Diurmentioning

confidence: 99%

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

et al. 2020

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Medicinal plants are used in traditional medicine to treat a wide range of ailments. The knowledge of them is handed down from generation to generation and is described in several pharmacopoeia and in the general literature. The immense biodiversity of the Brazilian flora, covering about 25% of all plant species worldwide, makes Brazil a huge potential source of medicinal plants. Indeed, many of these plant species are already used in the Brazilian ethnopharmacology for their probable effect to induce diuresis, to reduce fluid retention, and to treat cardiovascular and renal disorders. This review article describes and discusses the main native Brazilian medicinal plants (including some of their isolated compounds) used as diuretics. It also gives a comprehensive analysis of the most relevant scientific studies presented to date, as well as addressing a special topic with future prospects for plant species that have not yet been scientifically studied. In brief, several plants can be indicated for more detailed study, with a view to obtain scientific subsidies for a new and effective diuretic medicine in the future. These include Bauhinia forficata, Leandra dasytricha, and Tropaeolum majus. Other species have reputed medicinal properties but lack experimental assays to demonstrate their pharmacological effects (e.g., Mikania hirsutissima, Phyllanthus niruri, and Tagetes minuta). Several active principles are indicated as responsible for the diuretic effects of the plants studied, with emphasis on phenolic compounds as flavonoids, phenolic acids, and xanthones. These results should encourage more detailed preclinical, clinical, and phytochemical investigations on Brazilian plants in the future.

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Gallic acid improves cardiac dysfunction and fibrosis in pressure overload-induced heart failure

Cited by 61 publications

References 40 publications

Wnt-C59 Attenuates Pressure Overload-Induced Cardiac Hypertrophy via Interruption of Wnt Pathway

Wnt-C59 Attenuates Pressure Overload-Induced Cardiac Hypertrophy via Interruption of Wnt Pathway

Gallic Acid‐Loaded Zein Nanoparticles by Electrospraying Process

Promising Medicinal Plants with Diuretic Potential Used in Brazil: State of the Art, Challenges, and Prospects

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