Gallbladder Carcinoma: Analysis of Prognostic Factors in 132 Cases

Xu, Xiayu; Liu, Jun; Liu, Chang

doi:10.7314/apjcp.2012.13.6.2511

Cited by 17 publications

(7 citation statements)

References 13 publications

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“…In the studies of Barbhuiya et al, [13] Dipti Kalita et al [15] and Nissar Hussain et al [16] the gallstones were found in 77.67%, 72% and 86% cases of gallbladder carcinoma while in our study, 50% cases of gallbladder carcinoma were associated with stones. It suggests that gallstone is an important etiological factor for development of carcinoma which is also supported by the studies of Nissar Hussain et al [16] and Wang et al [17] Pigment stones were the most common type of stones found in our study which is concordant with the finding reported by Kimura et al [18] from Japan.…”

Section: Discussionsupporting

confidence: 83%

Clinicopathological Study of Gallbladder Lesions

Kumari¹,

Deshpande

Roy

2018

APALM

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Background: Gallbladder is one of the most frequently surgically resected organs which stores and concentrates the bile and is involved by both non neoplastic as well as neoplastic diseases. Chronic calculous cholecystitis is the most common benign lesion of gallbladder and pain abdomen is the commonest clinical presentation. Both non neoplastic and neoplastic lesions have similar clinical presentation and overlapping radiological findings. Methods:Total 550 cholecystectomy specimens were received in pathology department. Grossly, formalin fixed specimens were examined carefully and section were given from neck, fundus and body of gallbladder. Whenever it was necessary, additional sections were given. After processing, the H&E stained sections were studied thoroughly. All the clinical details were taken from case papers. Result:The commonly seen non neoplastic lesions were chronic calculous cholecystitis (405 cases), chronic cholecystitis (85 cases), Acute on chronic cholecystitis with or without stones (18 and 3 cases), acute necrotizing cholecystitis (2 cases), eosinophilic cholecystitis (3 cases), follicular cholecystitis (3cases), lymphoplasmacytic cholecystitis (1case), xathogranulomatous cholecystitis (9 cases), cholesterosis (4 cases), mucocele of gall bladder (2 cases), adenomyomatosis (3 cases) and gallbladder cholesterol polyp with cholecystitis (2 cases). Among neoplastic lesions 1 case was adenoma with severe dysplasia and 9 cases were adenocarcinoma. Conclusion:Chronic calculous cholecystitis was the most common lesion and out of 9 cases of carcinoma, 7 cases were diagnosed incidentally. Therefore, histopathological evaluation plays a critical role in identifying incidental gallbladder carcinoma for proper management of patients.

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Section: Discussionsupporting

confidence: 83%

Clinicopathological Study of Gallbladder Lesions

Kumari¹,

Deshpande

Roy

2018

APALM

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“…Chronic inflammation, infection and gall stones -are currently believed to be the factors leading to malignant transformation of gall bladder epithelium (Hamdani et al, 2012;Wang et al, 2012). Our study also supports association between gall stone and malignancy.…”

Section: Discussionsupporting

confidence: 77%

“…Wang et al (2012) observed that early diagnosis and timely radical surgery are directly correlated to the prognosis of the patients. Incidental detection of gall bladder cancer in cholecystectomy specimen do has been reported in 0.3-2% of all cholecystectomy performed for benign conditions (Lam et al, 2005;Sun et al 2005;Misra et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

Kalita

Pant²,

Singh³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…The prognosis of GBC depends on multiple variables-stage of disease, lymph node status and cellular differentiation. 4,5 Very little evidence exists on the use of tumor markers for prognostication in GBC. Elevated carbohdrate antigen 19-9 (CA 19-9) has been shown to be associated with poorer prognosis in pancreatic adenocarcinomas.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value of CA19-9 and CA242 in Gallbladder Cancer - An Exploratory Study

Agarwal¹,

Tiwari²,

Kumari³

et al. 2019

IJCMR

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Introduction: There are, at present, no biomarkers to predict to prognosis of Gallbladder cancer. We conducted a prospective exploratory study to evaluate the role to serum CA 19-9 and CA 242 as prognostic markers. Material and Methods: We enrolled consecutive patients for this study and CA 19-9 and 242 were estimated from venous samples. Association of these markers with clinical variables and median overall survival (OS) difference between patients who has raised versus normal levels of these markers was determined. Results: Sixty-two patients were enrolled for this study. Forty-four (71%) patients had elevated CA19-9. Thirty-nine (62.9%) patients had an raised CA242 levels. CA 19-9 was found to be significantly associated with the presence of jaundice (p=0.038) and advanced stage (p=0.009). Median OS of patients who had elevated CA 19-9 was 5.73 months compared to 8.33 months in patients who had normal CA 19-9. The difference was not statistically different (p= 0.15). Median OS for patients who had elevated CA 242 was 5.53 months, which was inferior to those who had normal levels (9.1 months). This difference approached, but was not statistically significant (p=0.055). Conclusion: This is the first study to show association between CA 19-9 and stage of disease in GBC. At present, CA 19-9 and CA 242 cannot be recommended as prognostic markers. However, role of CA 242 needs to be examined in a larger cohort of patients of GBC to establish its usefulness.

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Gallbladder Carcinoma: Analysis of Prognostic Factors in 132 Cases

Cited by 17 publications

References 13 publications

Clinicopathological Study of Gallbladder Lesions

Clinicopathological Study of Gallbladder Lesions

Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

Prognostic Value of CA19-9 and CA242 in Gallbladder Cancer - An Exploratory Study

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