Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

Kalita, Dipti; Pant, Leela; Singh, Sompal; Jain, Gaurav; Kudesia, Madhur; Gupta, Kusum; Kaur, Charanjeet

doi:10.7314/apjcp.2013.14.5.3315

Cited by 42 publications

(57 citation statements)

References 25 publications

(22 reference statements)

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“…In the studies of Barbhuiya et al, [13] Dipti Kalita et al [15] and Nissar Hussain et al [16] the gallstones were found in 77.67%, 72% and 86% cases of gallbladder carcinoma while in our study, 50% cases of gallbladder carcinoma were associated with stones. It suggests that gallstone is an important etiological factor for development of carcinoma which is also supported by the studies of Nissar Hussain et al [16] and Wang et al [17] Pigment stones were the most common type of stones found in our study which is concordant with the finding reported by Kimura et al [18] from Japan.…”

Section: Discussionmentioning

confidence: 35%

“…Same authors Barbhuiya et al, [13] Dipti Kalita et al [15] and Nissar Hussain et al [16] did extensive study on gallbladder carcinoma and found that adenocarcinoma was the most common type microscopically which is also a common observation in our study.…”

Section: Discussionmentioning

confidence: 49%

“…Among neoplastic lesions the incidence was peak in the age group of 21-40 years with slight increase in younger age while in studies of Barbhuiya et al, [13] Sharma JD et al [14] and Dipti Kalita et al, [15] the peak incidence was found in the age group 40-60 years, 41-60 years and 50-60 years respectively. This indicates that there is an increase in the frequency of gallbladder carcinoma in younger age groups.…”

Section: Discussionmentioning

confidence: 96%

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Clinicopathological Study of Gallbladder Lesions

Kumari¹,

Deshpande

Roy

2018

APALM

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Background: Gallbladder is one of the most frequently surgically resected organs which stores and concentrates the bile and is involved by both non neoplastic as well as neoplastic diseases. Chronic calculous cholecystitis is the most common benign lesion of gallbladder and pain abdomen is the commonest clinical presentation. Both non neoplastic and neoplastic lesions have similar clinical presentation and overlapping radiological findings. Methods:Total 550 cholecystectomy specimens were received in pathology department. Grossly, formalin fixed specimens were examined carefully and section were given from neck, fundus and body of gallbladder. Whenever it was necessary, additional sections were given. After processing, the H&E stained sections were studied thoroughly. All the clinical details were taken from case papers. Result:The commonly seen non neoplastic lesions were chronic calculous cholecystitis (405 cases), chronic cholecystitis (85 cases), Acute on chronic cholecystitis with or without stones (18 and 3 cases), acute necrotizing cholecystitis (2 cases), eosinophilic cholecystitis (3 cases), follicular cholecystitis (3cases), lymphoplasmacytic cholecystitis (1case), xathogranulomatous cholecystitis (9 cases), cholesterosis (4 cases), mucocele of gall bladder (2 cases), adenomyomatosis (3 cases) and gallbladder cholesterol polyp with cholecystitis (2 cases). Among neoplastic lesions 1 case was adenoma with severe dysplasia and 9 cases were adenocarcinoma. Conclusion:Chronic calculous cholecystitis was the most common lesion and out of 9 cases of carcinoma, 7 cases were diagnosed incidentally. Therefore, histopathological evaluation plays a critical role in identifying incidental gallbladder carcinoma for proper management of patients.

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Section: Discussionmentioning

confidence: 35%

Section: Discussionmentioning

confidence: 49%

Section: Discussionmentioning

confidence: 96%

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Clinicopathological Study of Gallbladder Lesions

Kumari¹,

Deshpande

Roy

2018

APALM

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“…[3] Inapparent (Incidental) gall bladder carcinoma is defined as carcinoma of gall bladder that was unrecognised before or at operation and detected for the first time on histopathology examination of gall bladder. These account for approximately 0.25 to 3 % of all cholecystectomy procedures performed for presumably benign disease of gall bladder [1].…”

Section: Discussionmentioning

confidence: 99%

Incidental Detection of Carcinoma Gall Bladder in Laparoscopic Cholecystectomy Specimens: A Thirteen Year Study of 23 Cases and Literature Review

Gulwani

Gupta

Kaur

2015

Indian J Surg Oncol

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Carcinoma of gall bladder is the most common malignancy of the biliary tract worldwide and is usually associated with poor prognosis. In this era of laparoscopic cholecystectomy, there has been increase in detection of early stage incidental gall bladder carcinoma in cholecystectomy specimens. A retrospective study was carried out in tertiary care hospital in central India. A total of 2990 patients underwent laparoscopic cholecystectomy during the year 2001-2013. Hospital records and histopathology reports of these patients were studied in detail. Twenty three cases of gall bladder carcinoma were detected incidentally accounting for an incidence of 0.76 %. It was more common in females with an M: F ratio of 1:1.9. Mean age of presentation was 57.8 years. Gall stones were present in 22 cases and one patient presented with features of acute cholecystitis. Three patients had associated xanthogranulomatous inflammation and 10 had associated intestinal metaplasia. It is not uncommon to encounter incidental malignancies of gall bladder in laparoscopic cholecystectomy specimens sent to histopathology for presumably benign disease. Histopathology reports must include comments on extent of infiltration, perineural invasion, tumor differentiation and nodal involvement for oncologist information and subsequent management of patients.

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“…UPGC has been reported in 0.3-2% of all cholecystectomy cases. 8 Early detection of this aggressive cancer is important, but the prognosis and consequences of UPGC have not been clarified. We evaluated the results of routine pathology of the gallbladder after cholecystectomy for benign gallbladder diseases with regard to UPGC.…”

mentioning

confidence: 99%

Incidental findings during routine pathological evaluation of gallbladder specimens: review of 1,747 elective laparoscopic cholecystectomy cases

Başak

Hasbahçeci

Canbak

et al. 2016

annals

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INTRODUCTION Cholecystectomy for benign gallbladder diseases can lead to previously undiagnosed gallbladder cancer during histopathological evaluation. Despite some controversy over its usefulness, histopathological evaluation of all gallbladder specimens is common in most hospitals. We evaluated the results of routine pathology of the gallbladder after cholecystectomy for benign gallbladder diseases with regard to unexpected primary gallbladder cancer (UPGC). METHODS Patients undergoing cholecystectomy because of benign gallbladder diseases between 2009 and 2013 were enrolled in this study. All gallbladder specimens were sent to the pathology department, and histopathological reports were examined in detail. The impact of demographic features on pathological diagnoses and prevalence of UPGC assessed. Data on additional interventions and postoperative survival for patients with UPGC were collected. RESULTS We enrolled 1,747 patients (mean age, 48.7±13.6 years). Chronic cholecystitis was the most common diagnosis (96.3%) and was associated significantly with being female (p=0.001). Four patients had UPGC (0.23%); one was stage T3 at the time of surgery, and the remaining three cases were stage T2. CONCLUSIONS Routine histopathological examination of the gallbladder is valuable for identification of cancer that requires further postoperative management.

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Impact of Routine Histopathological Examination of Gall Bladder Specimens on Early Detection of Malignancy - A Study of 4,115 Cholecystectomy Specimens

Cited by 42 publications

References 25 publications

Clinicopathological Study of Gallbladder Lesions

Clinicopathological Study of Gallbladder Lesions

Incidental Detection of Carcinoma Gall Bladder in Laparoscopic Cholecystectomy Specimens: A Thirteen Year Study of 23 Cases and Literature Review

Incidental findings during routine pathological evaluation of gallbladder specimens: review of 1,747 elective laparoscopic cholecystectomy cases

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