Background: Gallbladder is one of the most frequently surgically resected organs which stores and concentrates the bile and is involved by both non neoplastic as well as neoplastic diseases. Chronic calculous cholecystitis is the most common benign lesion of gallbladder and pain abdomen is the commonest clinical presentation. Both non neoplastic and neoplastic lesions have similar clinical presentation and overlapping radiological findings.
Methods:Total 550 cholecystectomy specimens were received in pathology department. Grossly, formalin fixed specimens were examined carefully and section were given from neck, fundus and body of gallbladder. Whenever it was necessary, additional sections were given. After processing, the H&E stained sections were studied thoroughly. All the clinical details were taken from case papers.
Result:The commonly seen non neoplastic lesions were chronic calculous cholecystitis (405 cases), chronic cholecystitis (85 cases), Acute on chronic cholecystitis with or without stones (18 and 3 cases), acute necrotizing cholecystitis (2 cases), eosinophilic cholecystitis (3 cases), follicular cholecystitis (3cases), lymphoplasmacytic cholecystitis (1case), xathogranulomatous cholecystitis (9 cases), cholesterosis (4 cases), mucocele of gall bladder (2 cases), adenomyomatosis (3 cases) and gallbladder cholesterol polyp with cholecystitis (2 cases). Among neoplastic lesions 1 case was adenoma with severe dysplasia and 9 cases were adenocarcinoma.
Conclusion:Chronic calculous cholecystitis was the most common lesion and out of 9 cases of carcinoma, 7 cases were diagnosed incidentally. Therefore, histopathological evaluation plays a critical role in identifying incidental gallbladder carcinoma for proper management of patients.
We report a case of a 6-year-old girl with primary Burkitt's lymphoma (BL) of endometrium and bilateral ovaries of 1-month duration. To the best of our knowledge, few cases of childhood primary BL of bilateral ovaries have been reported worldwide. However, extensive search of the published work did not reveal any case of primary BL of endometrium and both ovaries. Although rare, BL is a potentially curable malignancy with good prognosis.
Psammocarcinoma is a rare low-grade serous carcinoma arising either from ovary or peritoneum and is characterized by extensive psammomatous calcifications and invasion of surrounding structures. Prognostically, psammocarcinoma resembles borderline serous tumor and has a much more favorable outcome than the common serous carcinoma of ovary and peritoneum.
Cystic lesions of the thyroid encompass a wide and heterogeneous spectrum ranging from degenerative, developmental, inclusion, non neoplastic, benign to malignant tumors with no particular age and sex predilection. The most common differential diagnosis of cystic lesions include branchial cleft cyst, colloid cysts, thyroglossal cysts, papillary carcinoma and very rarely epidermal cyst. Epidermal inclusion cysts can be defined as epithelial cysts which grow slowly. The treatment is total excision together with cyst's capsule. We report this case of thyroid epidermoid cyst at a rare site in a 26 year old female which was diagnosed accurately on cytology and confirmed on histopathological examination.
Lymphomas account for 2%-5% of salivary gland neoplasms. The parotid gland is the most commonly involved, constituting 70% of the cases, followed by submandibular gland (25%), sublingual and minor salivary glands (<10%). In present study a 56 years old seropositive male presented with a submandibular gland swelling of 2 months duration; along with multiple cervical lymphadenopathy. Grossly a single, well encapsulated, grayish-white tissue measuring 3x2.5x2 cms was received. It was solid, grayish-white on cut section. Histology revealed features of diffuse large B cell lymphoma with myoepithelial sialadenitis. Immunohistochemistry showed positivity for LCA & CD20, thus confirming the histopathological diagnosis. Primary malignant lymphoma of salivary glands is uncommon. Inspite of malignant lymphoma being the second most common AIDS-associated neoplasm, it’s occurrence in submandibular gland is extremely rare.
Extraovarian peritoneal serous papillary carcinoma is an uncommon malignant tumour characterised by peritoneal involvement with ascites, which is similar to ovarian serous papillary carcinoma histologically. Our case involved only the surface and superficial cortex of the ovaries, with peritoneal involvement, as described in the literature.
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