Gall stones size, number, biochemical analysis and lipidogram- an association with gall bladder cancer: a study of 200 cases

Narang, Shveta; Goyal, Parul; Bal, Manjit Singh; Bandlish, Usha; Goyal, Sunder

doi:10.14319/ijcto.0203.10

Cited by 8 publications

(8 citation statements)

References 29 publications

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“…In the studies of Barbhuiya et al, [13] Dipti Kalita et al [15] and Nissar Hussain et al [16] the gallstones were found in 77.67%, 72% and 86% cases of gallbladder carcinoma while in our study, 50% cases of gallbladder carcinoma were associated with stones. It suggests that gallstone is an important etiological factor for development of carcinoma which is also supported by the studies of Nissar Hussain et al [16] and Wang et al [17] Pigment stones were the most common type of stones found in our study which is concordant with the finding reported by Kimura et al [18] from Japan.…”

Section: Discussionsupporting

confidence: 93%

Clinicopathological Study of Gallbladder Lesions

Kumari¹,

Deshpande

Roy

2018

APALM

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Background: Gallbladder is one of the most frequently surgically resected organs which stores and concentrates the bile and is involved by both non neoplastic as well as neoplastic diseases. Chronic calculous cholecystitis is the most common benign lesion of gallbladder and pain abdomen is the commonest clinical presentation. Both non neoplastic and neoplastic lesions have similar clinical presentation and overlapping radiological findings. Methods:Total 550 cholecystectomy specimens were received in pathology department. Grossly, formalin fixed specimens were examined carefully and section were given from neck, fundus and body of gallbladder. Whenever it was necessary, additional sections were given. After processing, the H&E stained sections were studied thoroughly. All the clinical details were taken from case papers. Result:The commonly seen non neoplastic lesions were chronic calculous cholecystitis (405 cases), chronic cholecystitis (85 cases), Acute on chronic cholecystitis with or without stones (18 and 3 cases), acute necrotizing cholecystitis (2 cases), eosinophilic cholecystitis (3 cases), follicular cholecystitis (3cases), lymphoplasmacytic cholecystitis (1case), xathogranulomatous cholecystitis (9 cases), cholesterosis (4 cases), mucocele of gall bladder (2 cases), adenomyomatosis (3 cases) and gallbladder cholesterol polyp with cholecystitis (2 cases). Among neoplastic lesions 1 case was adenoma with severe dysplasia and 9 cases were adenocarcinoma. Conclusion:Chronic calculous cholecystitis was the most common lesion and out of 9 cases of carcinoma, 7 cases were diagnosed incidentally. Therefore, histopathological evaluation plays a critical role in identifying incidental gallbladder carcinoma for proper management of patients.

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Section: Discussionsupporting

confidence: 93%

Clinicopathological Study of Gallbladder Lesions

Kumari¹,

Deshpande

Roy

2018

APALM

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“…Crushed stone crystals were subjected to biochemical analysis for qualitative presence of cholesterol, bile pigments, and mixed components by the method described by Oser. [4]…”

Section: Methodsmentioning

confidence: 99%

Histopathological changes in gallbladder mucosa associated with cholelithiasis: A prospective study

Singh

Kaur

et al. 2019

Niger J Surg

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Background and Aims: Cholelithiasis is known to produce diverse histopathological changes in the gallbladder mucosa. In the present study, we aimed to find the correlation between various gallstone characteristics (i.e., number, size, and morphological type) with the type of mucosal response in gallbladder mucosa (i.e., inflammation, hyperplasia, metaplasia, and carcinoma). Methods: The present study was conducted prospectively on 100 patients undergoing cholecystectomy for symptomatic cholecystitis. Gallstones were assessed for various parameters, i.e., number, size, and morphological type. Gallbladder mucosa was subjected to histopathological examination. Sections were taken from body, fundus, and neck of gallbladder. Results: Of 100 cases, maximum type was of mixed stones (54%) and was multiple in number (46%). However, gallstone type and number are nonsignificant variables to produce precancerous lesions (i.e., hyperplasia and metaplasia). Statistically significant results were obtained while comparing the mucosal response with gallstone size ( P = 0.012). Conclusion: As the gallstone size increases, the response in gallbladder mucosa changes from cholecystitis, hyperplasia, and metaplasia to carcinoma. Gallstone type and number are nonsignificant variables to produce precancerous lesions.

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“…Maximum crowding of the cases was seen in the age group 20-40 yr (58%), and the incidence dropped in older age groups, with only 6% cases in the > 60 years age group. The calculated mean age was 39.5 ± 13.5 yr. Narang et al [2] demonstrated similar results with maximum cases (58%) in the 30-40 yr age group. Bansal et al [3] and Tyagi et al [4] reported the mean age of 43.6 and 42.5 yr, respectively, which was slightly older than the mean of our study.…”

Section: Discussionmentioning

confidence: 54%

Histopathological changes in gall bladder mucosa in relation to the number, and size of gallstones, and analysis of the findings in the context of age distribution of the patients: A perspective

Sharma,

Walia,

Randhawa

et al. 2023

Ann Hepatobiliary Pancreat Surg

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To study histopathological changes in gall bladder mucosa in cholelithiasis patients, and analyse their relation to the number and size of gallstones. These findings were evaluated in the context of age distribution of the study population. Methods: One hundred cases of cholecystectomy were part of the study, which was conducted in collaboration with the pathology department. The time period of the study was January 2020 to June 2021. Results: Maximum cases had multiple stones (69.0%), while one third cases (31.0%) had solitary stones. While initial univariate analysis showed age (odds ratio [OR], 6.882; p = 0.043), gallstone number (OR, 9.1; p = 0.050), gallstone size (OR, 17.111; p = 0.013), and duration of symptom (OR, 34.125; p = 0.001) to be significant risk factors associated with gallbladder carcinoma, multivariate analysis found none of these variables to be significant. However, conditional multivariate analysis for the duration of symptom (p = 0.008; OR, 21.118) yielded significant p-value. With histopathological diagnoses, 5% of cases had gallbladder cancer. Conclusions: This study shed light on the rising incidence of cholelithiasis in the young population and the high rate of gallbladder carcinoma in Punjab, India. Although gall stone characteristics (size, number) and patient age appeared to be significant risk factors when their individual relation with gallbladder carcinoma was studied, multivariate analysis, could not prove that. Conditional multivariate analysis showed the duration of symptom to be the only significant risk factor associated with gallbladder carcinoma. Further research with larger sample size is needed to study the rising incidence of gallbladder carcinoma, and the risk factors associated with it.

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Gall stones size, number, biochemical analysis and lipidogram- an association with gall bladder cancer: a study of 200 cases

Cited by 8 publications

References 29 publications

Clinicopathological Study of Gallbladder Lesions

Clinicopathological Study of Gallbladder Lesions

Histopathological changes in gallbladder mucosa associated with cholelithiasis: A prospective study

Histopathological changes in gall bladder mucosa in relation to the number, and size of gallstones, and analysis of the findings in the context of age distribution of the patients: A perspective

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