Histopathological changes in gallbladder mucosa associated with cholelithiasis: A prospective study

Abstract

Background and Aims: Cholelithiasis is known to produce diverse histopathological changes in the gallbladder mucosa. In the present study, we aimed to find the correlation between various gallstone characteristics (i.e., number, size, and morphological type) with the type of mucosal response in gallbladder mucosa (i.e., inflammation, hyperplasia, metaplasia, and carcinoma). Methods: The present study was conducted prospectively on 100 patients undergoing cholecystectomy for symptomatic cholecystitis. Gallstones were assessed for various parameters, i.e., number, size, and morphological type. Gallbladder mucosa was subjected to histopathological examination. Sections were taken from body, fundus, and neck of gallbladder. Results: Of 100 cases, maximum type was of mixed stones (54%) and was multiple in number (46%). However, gallstone type and number are nonsignificant variables to produce precancerous lesions (i.e., hyperplasia and metaplasia). Statistically significant results were obtained while comparing the mucosal response with gallstone size ( P = 0.012). Conclusion: As the gallstone size increases, the response in gallbladder mucosa changes from cholecystitis, hyperplasia, and metaplasia to carcinoma. Gallstone type and number are nonsignificant variables to produce precancerous lesions.

Bacterial Profile of Bile Culture from Patients Undergoing Cholecystectomy

“…On the other hand in the present study, 70% of patients were female, with male:female ratio 1:2.3. This is in line with Singh et al [11] who reported that 85% of their patients were female. Similar results have been reported in the studies of Mathur et al [16] and Mohan et al [17] who reported that 86.97% and 86.54% of patients were female, respectively.…”

“…Many of the previous studies are in accordance with these results. In a recent study, Singh et al [11] studied the incidence of GB malignancy in 100 Indian patients with cholecystitis. The majority of the patients in this study were in the age group between 40 and 49 years, with a mean age of 44.1 years.…”

The Spectrum of Gallbladder Histopathology at a Tertiary Hospital in a Developing Country: A Retrospective Study

“…The spectrum of ailments that afflict the gallbladder (GB) can be inflammatory, congenital, or neoplastic in nature [1,2]. The signs and symptoms elicited by these pathologies evoke the need for surgical intervention through the means of either open or laparoscopic cholecystectomy.…”

Histopathologic Spectrum of Gallbladder in Cholecystectomy Specimens

“…Thickening of gall bladder wall is striking feature in cholecystitis. 8 In our study, Gall stone disease was predominantly seen in females (80.12%) as compared to males (19.87%). Female sex hormones appear to play a role, especially between the ages of 30 and 50 years.…”