Functional Graphene Oxide-Based Nanosheets for Photothermal Therapy

Lim, Jae Hyun; Kim, Da Eun; Kim, Eun-Joong; Ahrberg, Christian D.; Chung, Bong Geun

doi:10.1007/s13233-018-6067-3

Cited by 58 publications

(39 citation statements)

References 48 publications

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“…Graphene, graphene oxide, and other derivatives have been extensively explored for theranostic applications in nanomedicines due to their low cost, large molecular surface area, chemical and mechanical stability, low toxicity and biocompatibility. Graphene also exhibits high photonic energy absorption in the NIR range, making it a suitable candidate for PTT 70,71 . Fiorica et al developed a hyaluronic acid based nanogel network with graphene oxide incorporated into the nano-structure.…”

Section: Graphene Oxide-based Nanomedicinesmentioning

confidence: 99%

A Review on the Scope of Photothermal Therapy–Based Nanomedicines in Preclinical Models of Colorectal Cancer

Khot

Andrew

Svavarsdottir

et al. 2019

Clinical Colorectal Cancer

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Oncological thermal ablation involves the use of hyperthermic temperatures to damage and treat solid cancers. Thermal ablation is being investigated as a method of treatment in colorectal cancers and has the potential to complement conventional anti-cancer treatments in managing local recurrence and metastatic disease. Photothermal therapy utilises photosensitive agents to generate local heat and induce thermal ablation. There is growing interest in developing nanotechnology platforms to deliver such photosensitive agents. An advantage of nanomedicines is their multifunctionality with the capability to deliver combinations of chemotherapeutics and cancer-imaging agents. To date, there have been no clinical studies evaluating photothermal therapy-based nanomedicines in colorectal cancers. This review presents the current scope of pre-clinical studies, investigating nanomedicines that have been developed for delivering multimodal photothermal therapy to colorectal cancers, with an emphasis on potential clinical applications.

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Section: Graphene Oxide-based Nanomedicinesmentioning

confidence: 99%

A Review on the Scope of Photothermal Therapy–Based Nanomedicines in Preclinical Models of Colorectal Cancer

Khot

Andrew

Svavarsdottir

et al. 2019

Clinical Colorectal Cancer

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“…These findings promise the potential use of this system for complete tumor ablation and metastasis prevention. Several research groups have designed hybrid materials comprising photosensitizer-linked graphene/GO (GO-fullerene C60) [72], RGO-Ru-PEG [73], folic acid-GO-manganese dioxide [74], GO-enwrapped SiO 2 /TiO 2 hollow nanoparticles loaded with protoporphyrin IX [75], and NGO-UCNP-Ce6 [76] for combined PTT and PDT in a single platform. Effective delivery of photosensitizers for PDT along with enhanced fluorescence imaging was achieved by Yan et al [77].…”

Section: Graphene Substrates For Photothermal Therapy and Photodynamimentioning

confidence: 99%

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

2019

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HIGHLIGHTS• The introduction of graphene will certainly uncover new advanced materials, and many more future technologies will become realistic in the forthcoming years.• The present review article includes more recent publications about the biomedical application and cellular interaction of graphene. It is also updated with modern approaches such as use of graphene inks for 3D printing application.• Moreover, the importance of protein corona in modulating the cellular interaction, which was overlooked in previous review publications, is also included in this article.• The possible biological outcomes and toxicity when graphene is exposed to living organisms at the cellular and organ level are explained.ABSTRACT Graphene, sp 2 hybridized carbon framework of one atom thickness, is reputed as the strongest material to date. It has marked its impact in manifold applications including electronics, sensors, composites, and catalysis. Current state-of-the-art graphene research revolves around its biomedical applications. The two-dimensional (2D) planar structure of graphene provides a large surface area for loading drugs/biomolecules and the possibility of conjugating fluorescent dyes for bioimaging. The high near-infrared absorbance makes graphene ideal for photothermal therapy. Henceforth, graphene turns out to be a reliable multifunctional material for use in diagnosis and treatment.It exhibits antibacterial property by directly interacting with the cell membrane. Potential application of graphene as a scaffold for the attachment and proliferation of stem cells and neuronal cells is captivating in a tissue regeneration scenario. Fabrication of 2D graphene into a 3D structure is made possible with the help of 3D printing, a revolutionary technology having promising applications in tissue and organ engineering. However, apart from its advantageous application scope, use of graphene raises toxicity concerns. Several reports have confirmed the potential toxicity of graphene and its derivatives, and the inconsistency may be due to the lack of standardized consensus protocols. The present review focuses on the hidden facts of graphene and its biomedical application, with special emphasis on drug delivery, biosensing, bioimaging, antibacterial, tissue engineering, and 3D printing applications.

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“…Herein, the modification of GO‐based drug delivery with a PDA coating to prepare PDA composites has been proposed as an approach to improve the biocompatibility and dispersitivity of GO . In addition, the synergistic effect between GO and PDA can further improve the photothermal therapy . The applications of PDA composites for biomedical purposes are summarized in Table .…”

Section: Pda Composite Structuresmentioning

confidence: 99%

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

Tran

Batul

Bhave

et al. 2019

Biotechnology Journal

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Since the first time mussel‐inspired polymer polydopamine (PDA) was discovered, it has gained enormous attention from numerous scientists, especially those working in the field of drug delivery and bacterial and tumor treatment, due to its distinctive properties, such as surface chemistry, biocompatibility, capability to adhere to any surface, and excellent photothermal conversion. Studies using PDA in various types of structures for therapeutic purposes have been carried out extensively in recent years. Considering the rapid development in the area, this review aims to cover and highlight the latest achievements (from 2016 to present) with respect to PDA‐based materials for therapeutic purposes. A description of the diverse structures of PDA and its formation strategy, including colloidal particles, hollow structures, and coating films, are discussed. In addition, the main focus of this review is on the therapeutic applications of these PDA nanostructures.

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Functional Graphene Oxide-Based Nanosheets for Photothermal Therapy

Cited by 58 publications

References 48 publications

A Review on the Scope of Photothermal Therapy–Based Nanomedicines in Preclinical Models of Colorectal Cancer

A Review on the Scope of Photothermal Therapy–Based Nanomedicines in Preclinical Models of Colorectal Cancer

Comprehensive Application of Graphene: Emphasis on Biomedical Concerns

Current Advances in the Utilization of Polydopamine Nanostructures in Biomedical Therapy

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