Early detection of physiological deterioration has been shown to improve patient outcomes. Due to recent improvements in technology, comprehensive outpatient vital signs monitoring is now possible. This is the first review to collate information on all wearable devices on the market for outpatient physiological monitoring.A scoping review was undertaken. The monitors reviewed were limited to those that can function in the outpatient setting with minimal restrictions on the patient’s normal lifestyle, while measuring any or all of the vital signs: heart rate, ECG, oxygen saturation, respiration rate, blood pressure and temperature.A total of 270 papers were included in the review. Thirty wearable monitors were examined: 6 patches, 3 clothing-based monitors, 4 chest straps, 2 upper arm bands and 15 wristbands. The monitoring of vital signs in the outpatient setting is a developing field with differing levels of evidence for each monitor. The most common clinical application was heart rate monitoring. Blood pressure and oxygen saturation measurements were the least common applications. There is a need for clinical validation studies in the outpatient setting to prove the potential of many of the monitors identified.Research in this area is in its infancy. Future research should look at aggregating the results of validity and reliability and patient outcome studies for each monitor and between different devices. This would provide a more holistic overview of the potential for the clinical use of each device.

Oncological thermal ablation involves the use of hyperthermic temperatures to damage and treat solid cancers. Thermal ablation is being investigated as a method of treatment in colorectal cancers and has the potential to complement conventional anti-cancer treatments in managing local recurrence and metastatic disease. Photothermal therapy utilises photosensitive agents to generate local heat and induce thermal ablation. There is growing interest in developing nanotechnology platforms to deliver such photosensitive agents. An advantage of nanomedicines is their multifunctionality with the capability to deliver combinations of chemotherapeutics and cancer-imaging agents. To date, there have been no clinical studies evaluating photothermal therapy-based nanomedicines in colorectal cancers. This review presents the current scope of pre-clinical studies, investigating nanomedicines that have been developed for delivering multimodal photothermal therapy to colorectal cancers, with an emphasis on potential clinical applications.

Three-dimensional (3D) spheroidal cell cultures are now recognised as better models of cancers as compared to traditional cell cultures. However, established 3D cell culturing protocols and techniques are time-consuming, manually laborious and often expensive due to the excessive consumption of reagents. Microfluidics allows for traditional laboratory-based biological experiments to be scaled down into miniature custom fabricated devices, where cost-effective experiments can be performed through the manipulation and flow of small volumes of fluid. In this study, we characterise a 3D cell culturing microfluidic device fabricated from a 3D printed master. HT29 cells were seeded into the device and 3D spheroids were generated and cultured through the perfusion of cell media. Spheroids were treated with 5-Fluorouracil for five days through continuous perfusion and cell viability was analysed on-chip at different time points using fluorescence microscopy and Lactate dehydrogenase (LDH) assay on the supernatant. Increasing cell death was observed in the HT29 spheroids over the five-day period. The 3D cell culturing microfluidic device described in this study, permits on-chip anti-cancer treatment and viability analysis, and forms the basis of an effective platform for the high-throughput screening of anti-cancer drugs in 3D tumour spheroids.

This is a repository copy of The role of ABCG2 in modulating responses to anti-cancer photodynamic therapy.

Female representation in medicine is increasing, however women make up only a small percentage of senior roles in the NHS. Only 36% of consultants are female with wide variation between specialties ranging from 12% of surgeons to over half of paediatricians, gynaecologists, and directors of public health. Women comprise 77% of the NHS workforce and account for 44% of chief executives of all NHS Trusts and 47% of executive directors. This chapter analyses the role of women as leaders within the medical world and compares the representation of women in senior leadership roles within medicine and other parallel, male-dominated working environments. Alternative forms of leadership such as mentoring, coaching, and sponsorship are also considered.

This is a repository copy of Understanding the mechanisms of cell death in photothermal nanomedicines.

Female representation in medicine is increasing, however women make up only a small percentage of senior roles in the NHS. Only 36% of consultants are female with wide variation between specialties ranging from 12% of surgeons to over half of paediatricians, gynaecologists, and directors of public health. Women comprise 77% of the NHS workforce and account for 44% of chief executives of all NHS Trusts and 47% of executive directors. This chapter analyses the role of women as leaders within the medical world and compares the representation of women in senior leadership roles within medicine and other parallel, male-dominated working environments. Alternative forms of leadership such as mentoring, coaching, and sponsorship are also considered.