Functional biomaterials for tendon/ligament repair and regeneration

Tang, Yunkai; Wang, Zhen; Xiang, Lei; Zhao, Zhenyu; Cui, Wenguo

doi:10.1093/rb/rbac062

Cited by 25 publications

(11 citation statements)

References 185 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After these and other modifications, two proα1 chains and one proα2 chain are folded into a triple helix structure from the C- to the N-terminus [ 49 ]. Subsequent to folding, an offset, parallel packing of triple-helices is generated to form microfibrils [ 50 ]. The three-dimensional structure is featured by a 67-nm D-periodic repeat [ 51 ].…”

Section: Discussionmentioning

confidence: 99%

Human extracellular matrix (ECM)-like collagen and its bioactivity

Zhou,

Li,

Pan

et al. 2024

Regenerative Biomaterials

View full text Add to dashboard Cite

Collagen, the most abundant structural protein in the human extracellular matrix (ECM), provides essential support for tissues and guides tissue development. Despite its widespread use in tissue engineering, there remains uncertainty regarding the optimal selection of collagen sources. Animal-derived sources pose challenges such as immunogenicity, while the recombinant system is hindered by diminished bioactivity. In this study, we hypothesized that human ECM-like collagen (hCol) could offer an alternative for tissue engineering. In this study, a facile platform was provided for generating hCol derived from mesenchymal stem cells (MSCs) with a hierarchical structure and biochemical properties resembling native collagen. Our results further demonstrated that hCol could facilitate basal biological behaviors of human adipose-derived stem cells (hASCs), including viability, proliferation, migration and adipocyte-like phenotype. Additionally, it could promote cutaneous wound closure. Due its high similarity to native collagen and good bioactivity, hCol holds promise as a prospective candidate for in vitro and in vivo applications in tissue engineering.

show abstract

Section: Discussionmentioning

confidence: 99%

Human extracellular matrix (ECM)-like collagen and its bioactivity

Zhou,

Li,

Pan

et al. 2024

Regenerative Biomaterials

View full text Add to dashboard Cite

show abstract

“…Although cells contain genetic information about the structural patterns of the tissue, mechanical stimuli can condition the genetic instructions stored in the cells. 84 Cyclic uniaxial mechanical loading of TSCs has demonstrated that proliferative capability increases and a loading magnitude-dependent differentiation effect has been observed, promoting either symmetric or asymmetric division. 85 In the symmetric division, TSCs divide into two identical daughter cells, in the asymmetric one instead, one daughter cell is identical to the original one (self-renewal) while another becomes specialized.…”

Section: Tendon Mechanical Propertiesmentioning

confidence: 99%

Tendon tissue engineering: An overview of biologics to promote tendon healing and repair

Citro,

Clerici,

Boccaccini

et al. 2023

J Tissue Eng

View full text Add to dashboard Cite

Tendons are dense connective tissues with a hierarchical polarized structure that respond to and adapt to the transmission of muscle contraction forces to the skeleton, enabling motion and maintaining posture. Tendon injuries, also known as tendinopathies, are becoming more common as populations age and participation in sports/leisure activities increases. The tendon has a poor ability to self-heal and regenerate given its intrinsic, constrained vascular supply and exposure to frequent, severe loading. There is a lack of understanding of the underlying pathophysiology, and it is not surprising that disorder-targeted medicines have only been partially effective at best. Recent tissue engineering approaches have emerged as a potential tool to drive tendon regeneration and healing. In this review, we investigated the physiochemical factors involved in tendon ontogeny and discussed their potential application in vitro to reproduce functional and self-renewing tendon tissue. We sought to understand whether stem cells are capable of forming tendons, how they can be directed towards the tenogenic lineage, and how their growth is regulated and monitored during the entire differentiation path. Finally, we showed recent developments in tendon tissue engineering, specifically the use of mesenchymal stem cells (MSCs), which can differentiate into tendon cells, as well as the potential role of extracellular vesicles (EVs) in tendon regeneration and their potential for use in accelerating the healing response after injury.

show abstract

“…Electrospinning technology occurs when a viscoelastic polymer fluid is extruded from a spinneret under the electrostatic repulsive force of a strong electric field, and the surface tension produces a hanging droplet. After electrification, the electrostatic repulsion between surface charges with the same symbol causes the droplet to be deformed into a Taylor cone, and the charged jet is ejected from the Taylor cone [ 47 ]. Different preparation processes will produce multiscale structure repair products.…”

Section: Functional Electrospinning Products Of 3d Structures For Ten...mentioning

confidence: 99%

Biodegradable Polymer Electrospinning for Tendon Repairment

et al. 2023

View full text Add to dashboard Cite

With the degradation after aging and the destruction of high-intensity exercise, the frequency of tendon injury is also increasing, which will lead to serious pain and disability. Due to the structural specificity of the tendon tissue, the traditional treatment of tendon injury repair has certain limitations. Biodegradable polymer electrospinning technology with good biocompatibility and degradability can effectively repair tendons, and its mechanical properties can be achieved by adjusting the fiber diameter and fiber spacing. Here, this review first briefly introduces the structure and function of the tendon and the repair process after injury. Then, different kinds of biodegradable natural polymers for tendon repair are summarized. Then, the advantages and disadvantages of three-dimensional (3D) electrospun products in tendon repair and regeneration are summarized, as well as the optimization of electrospun fiber scaffolds with different bioactive materials and the latest application in tendon regeneration engineering. Bioactive molecules can optimize the structure of these products and improve their repair performance. Importantly, we discuss the application of the 3D electrospinning scaffold’s superior structure in different stages of tendon repair. Meanwhile, the combination of other advanced technologies has greater potential in tendon repair. Finally, the relevant patents of biodegradable electrospun scaffolds for repairing damaged tendons, as well as their clinical applications, problems in current development, and future directions are summarized. In general, the use of biodegradable electrospun fibers for tendon repair is a promising and exciting research field, but further research is needed to fully understand its potential and optimize its application in tissue engineering.

show abstract

Functional biomaterials for tendon/ligament repair and regeneration

Cited by 25 publications

References 185 publications

Human extracellular matrix (ECM)-like collagen and its bioactivity

Human extracellular matrix (ECM)-like collagen and its bioactivity

Tendon tissue engineering: An overview of biologics to promote tendon healing and repair

Biodegradable Polymer Electrospinning for Tendon Repairment

Contact Info

Product

Resources

About