Fully physically cross-linked double network hydrogels with strong mechanical properties, good recovery and self-healing properties

Ye, Lina; Lv, Qiong; Sun, Xingyue; Liang, Yongzhi; Fang, Pengwei; Yuan, Xue-Ming; Li, Ming; Zhang, Xianzuo; Shang, Xifu; Liang, Haiyi

doi:10.1039/c9sm02071c

Cited by 27 publications

(18 citation statements)

References 36 publications

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“…Compared with mixed crosslinking or pure chemical crosslinking, Agar/PVA DN hydrogel demonstrated enhanced mechanical properties ( Sabzi et al, 2017 ). At the same time, double physical crosslinking hydrogel also showed good self-healing properties ( Sabzi et al, 2017 ; Ye et al, 2020 ). Some studies have reported that degradable DN hydrogels are used to induce cartilage differentiation.…”

Section: The Fabrication Methods Of Hydrogels With Different Stiffnessmentioning

confidence: 86%

A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair

Luo

Tan

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

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Tissue repair after trauma and infection has always been a difficult problem in regenerative medicine. Hydrogels have become one of the most important scaffolds for tissue engineering due to their biocompatibility, biodegradability and water solubility. Especially, the stiffness of hydrogels is a key factor, which influence the morphology of mesenchymal stem cells (MSCs) and their differentiation. The researches on this point are meaningful to the field of tissue engineering. Herein, this review focus on the design of hydrogels with different stiffness and their effects on the behavior of MSCs. In addition, the effect of hydrogel stiffness on the phenotype of macrophages is introduced, and then the relationship between the phenotype changes of macrophages on inflammatory response and tissue repair is discussed. Finally, the future application of hydrogels with a certain stiffness in regenerative medicine and tissue engineering has been prospected.

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Section: The Fabrication Methods Of Hydrogels With Different Stiffnessmentioning

confidence: 86%

A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair

Luo

Tan

Zhu

et al. 2022

Front. Bioeng. Biotechnol.

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“…Then, an AAm network is formed by UV irradiation. There are many other reports of one‐pot synthesis of DN gels combining such a network by chemical crosslinking and a network by physical crosslinking 25–29 …”

Section: Introductionmentioning

confidence: 99%

“…There are many other reports of one-pot synthesis of DN gels combining such a network by chemical crosslinking and a network by physical crosslinking. [25][26][27][28][29] In contrast, few studies have been reported of a simple one-shot (one-pot) polymerization method for the fabrication of gels having a structure in which both networks are connected by chemical crosslinking. We recently reported DN hydrogels synthesized by radical polymerization with the simultaneous addition of monomers and crosslinkers with different reactivity, that is, AAm and sodium p-styrenesulfonate (SS) as the monomers, and N,N'methylenebisacrylamide (bisAA) and sodium divinylbenzenesulfonate (DVBS) as the corosslinkers.…”

Section: Introductionmentioning

confidence: 99%

One‐shot radical polymerization of vinyl monomers with different reactivity accompanying spontaneous delay of polymerization for the synthesis of double‐network hydrogels

Dohi

Suzuki

Matsumoto

2020

Polymer International

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Double‐network hydrogels were conveniently synthesized by the one‐shot radical polymerization of an ionic monomer for the first network and a non‐ionic monomer for the second network in the presence of crosslinkers by simultaneous addition of the monomers, that is, one‐shot and spontaneous two‐step polymerization accompanying the delay of polymerization of a second network monomer. We analyzed the polymerization process based on the conversion of each monomer during the reaction in the absence of crosslinkers. Then we fabricated the double‐network hydrogels using several polymerization systems consisting of a conjugated monomer and a non‐conjugated monomer in the presence of the dual crosslinkers. We analyzed the swelling, mechanical and viscoelastic properties of hydrogels synthesized by one‐shot radical polymerization to confirm the production mechanism and the network structure of the hydrogels. © 2020 Society of Chemical Industry

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“…Indeed, the damping ability of the CDN-gel mainly depends on its elasticity. A stiff hydrogel cannot absorb enough of the shock, while a soft hydrogel does not have a sufficient response speed to resolve vibrations within a certain frequency [ 45 , 46 ]. The excellent elasticity and recovery properties of GEL-0.5 provide it with good damping ability.…”

Section: Resultsmentioning

confidence: 99%

Multi-Sacrificial Bonds Enhanced Double Network Hydrogel with High Toughness, Resilience, Damping, and Notch-Insensitivity

Sun

Qiu

et al. 2020

Polymers

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The engineering applications of hydrogels are generally limited by the common problem of their softness and brittlness. In this study, a composite double network ionic hydrogel (CDN-gel) was obtained by the facile visible light triggered polymerization of acrylic acid (AA), polyvinyl alcohol (PVA), and hydrolyzed triethoxyvinylsilane (TEVS) and subsequent salt impregnation. The resulting CDN-gels exhibited high toughness, recovery ability, and notch-insensitivity. The tensile strength, fracture elongation, Young’s modulus, and toughness of the CDN-gels reached up to ~21 MPa, ~700%, ~3.5 MPa, and ~48 M/m3, respectively. The residual strain at a strain of 200% was only ~25% after stretch-release of 1000 cycles. These properties will enable greater application of these hydrogel materials, especially for the fatigue resistance of tough hydrogels, as well as broaden their applications in damping.

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Fully physically cross-linked double network hydrogels with strong mechanical properties, good recovery and self-healing properties

Abstract: Fully physically cross-linked curdlan/HPAAm double network hydrogels show strong mechanical properties, good recovery and self-healing properties.

Cited by 27 publications

References 36 publications

A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair

A Review on the Design of Hydrogels With Different Stiffness and Their Effects on Tissue Repair

One‐shot radical polymerization of vinyl monomers with different reactivity accompanying spontaneous delay of polymerization for the synthesis of double‐network hydrogels

Multi-Sacrificial Bonds Enhanced Double Network Hydrogel with High Toughness, Resilience, Damping, and Notch-Insensitivity

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