Fullerene-based amino acid ester chlorides self-assembled as spherical nano-vesicles for drug delayed release

Increasing the Resistance of Living Cells against Oxidative Stress by Nonnatural Surfactants as Membrane Guards

“…Other researchers working on amphiphilic fullerenes could also observe vesicle-like structures. 19,23,42,43 Investigations using cryogenic transmission electron microscopy (cryo-TEM) confirm this (Figure 3c). The size of the hollow aggregates is in agreement with the DLS data.…”

“…Because the packing parameter of ( 4 ) is close to 1, one can expect a tendency for the formation of bilayered or vesicle-like structures. Other researchers working on amphiphilic fullerenes could also observe vesicle-like structures. ,,, Investigations using cryogenic transmission electron microscopy (cryo-TEM) confirm this (Figure c). The size of the hollow aggregates is in agreement with the DLS data.…”

Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

“…In vitro drug release profiles revealed the potential of implication this NDDP under low pH conditions of cancerous cells where the drug delivery cluster is believed to be significantly protonated, thereby improving drug separation from B 24 N 24 fullerene and release kinetics from surface of the cluster [60]. Fullerene exhibiting amphiphilic and self-assembly characters is of particular interest for sustained and delayed drug release performance, and tumor imaging [61,62]. In this sense a C 60 R 5 Cl fullerene (R: 4-aminobutyric methyl ester or glutamic acid methyl ester or phenylalanine methyl ester; size 80–135 nm depending on R) has been successfully used for in vitro delayed release of several anti-cancer drugs (cyclophosphamide, 5-FU, cisplatin).…”

“…In this sense a C 60 R 5 Cl fullerene (R: 4-aminobutyric methyl ester or glutamic acid methyl ester or phenylalanine methyl ester; size 80–135 nm depending on R) has been successfully used for in vitro delayed release of several anti-cancer drugs (cyclophosphamide, 5-FU, cisplatin). The study demonstrated that drug loading and release rate depend on the nature of R [62]. Similarly another novel amphiphilic phototheranostic platform based on fullerene C 70 and Chlorin e6 (Ce6) nanovesicles (FCNVs) also showed effective tumor imaging and cancer treatment potential.…”

High shear spheroidal topological fluid flow induced coating of polystyrene beads with C60 spicules

“…Spheroidal like fullerene C 60 comprised of sp 2 carbon atoms arranged at the vertices of a truncated icosahedron 1 nm in diameter 1 can self-assemble into a variety of nano-structures, including rods, prisms, cones, spikes and vesicles. [1][2][3][4] Such structures, depending on their size and morphology, have a variety of applications including in photodetectors, sensors, solar cells, light emitting diodes and drug delivery. 2,5 In addition, chemically modified fullerene C 60 has application for controlled slow release of encapsulated drugs.…”