Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

Naz, Safia; Shamoon, Muhammad; Wang, Rui; Zhang, Li; Zhou, Juan; Chen, Jinghua

doi:10.3390/ijms20040965

Cited by 64 publications

(50 citation statements)

References 104 publications

(103 reference statements)

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“…In addition, these nanostructures could modulate the drug release, and facilitate drug imaging, and monitoring its function. Besides, being flexible to various stimuli (i.e., temperature, pH, chemicals, pressure, and magnetic and electric fields) makes the CNTs a great catch for nanopharmacology (Naz et al, 2019).…”

Section: Carbon Nanotubes (Cnts) and Nanofibersmentioning

confidence: 99%

Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders

Moradi

Momtaz

Bayrami

et al. 2020

Front. Bioeng. Biotechnol.

113

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Nanotechnology is one of the methods that influenced human life in different ways and is a substantial approach that assists to overcome the multiple limitations of various diseases, particularly neurodegenerative disorders (NDs). Diverse nanostructures such as polymer nanoparticles, lipid nanoparticles, nanoliposomes, nano-micelles, and carbon nanotubes (CNTs); as well as different vehicle systems including poly lacticco-glycolic acid, lactoferrin, and polybutylcyanoacrylate could significantly increase the effectiveness, reduce the side effects, enhance the stability, and improve the pharmacokinetics of many drugs. NDs belong to a group of annoying and debilitating diseases that involve millions of people worldwide. Previous studies revealed that several nanoformulations from a number of natural products such as curcumin (Cur), quercetin (QC), resveratrol (RSV), piperine (PIP), Ginkgo biloba, and Nigella sativa significantly improved the condition of patients diagnosed with NDs. Drug delivery to the central nervous system (CNS) has several limitations, in which the blood brain barrier (BBB) is the main drawback for treatment of NDs. This review discusses the effects of herbalbased nanoformulations, their advantages and disadvantages, to manage NDs. In summary, we conclude that herbal-based nano systems have promising proficiency in treatment of NDs, either alone or in combination with other drugs.

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Section: Carbon Nanotubes (Cnts) and Nanofibersmentioning

confidence: 99%

Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders

Moradi

Momtaz

Bayrami

et al. 2020

Front. Bioeng. Biotechnol.

113

View full text Add to dashboard Cite

show abstract

“…Advance in Nanotechnology led to the development of various nanomaterials such as carbon nanotubes, fullerene and quantum dots that provide valuable materials for medical therapy and diagnosis. In particular, nanoparticles, tiny particles of the size range 40-400 nm are important for drug delivery and a variety of nanoparticles have been developed over the years [2,3]. These include Figure 3 shows MSN nanoparticles we used for biomedical application [26].…”

Section: Nanoparticlesmentioning

confidence: 99%

“…Nanotechnology that was initiated in 1960s has generated a variety of nanomaterials valuable for biomedical applications such as cancer therapy [1]. Of particular interest are nanoparticles, small particles of the size ranging from 40 to 400 nm [2][3][4]. Various materials have been used to generate nanoparticles including organic nanoparticles such as liposomes, synthetic polymers, micelles, protein and biomolecules as well as inorganic nanoparticles such as mesoporous silica nanoparticles, gold nanoparticles and diamond nanoparticles [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

Convergence of the Study on Monochromatic X-rays and the Research on Nanoparticles Opens Up a Possibility to Develop a New Type of Radiation Therapy

Tamanoi¹,

Matsumoto²,

Đoàn³

et al. 2020

Preprint

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Conventional radiation therapy uses white X-rays that consist of a mixture of X-ray waves with various energy levels. In contrast, a monochromatic X-ray (monoenergetic X-ray) has a single energy level. Irradiation of high Z elements with a synchrotron generated monochromatic X-ray with the energy at or higher than the K-edge energy of the element results in the production of the Auger electrons that cause DNA damage leading to cell killing. Delivery of high Z elements into cancer cells and tumor mass can be facilitated by the use of nanoparticles. Mesoporous silica nanoparticles (MSNs) have been shown to be effective in delivering high Z elements to cancer cells. A proof of principle experiment was reported that demonstrated the feasibility of this approach. This opens up a possibility to pursue the Auger cancer therapy by the combined use of MSNs loaded with high Z elements and monochromatic X-rays. Similar cancer therapies using other types of quantum beams such as neutron, proton and carbon ion beams can be envisioned.

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“…LDHs are reported as very efficient drug nanovehicles [218,219] since, in comparison to other inorganic nanovehicles, including silica and gold nanoparticles, quantum dots, and carbon nanotubes, they are featured with excellent biocompatibility [205], high drug loading capacity [220], and pH-responsive property [221], with biodegradability in the cellular cytoplasm [222]. Such outstanding properties make LDHs an efficient non-viral drug delivery vehicle, and also a reservoir for bioactive or bio-fragile molecules.…”

Section: Drug Deliverymentioning

confidence: 99%

Layered Double Hydroxides: A Toolbox for Chemistry and Biology

et al. 2019

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Layered double hydroxides (LDHs) are an emergent class of biocompatible inorganic lamellar nanomaterials that have attracted significant research interest owing to their high surface-to-volume ratio, the capability to accumulate specific molecules, and the timely release to targets. Their unique properties have been employed for applications in organic catalysis, photocatalysis, sensors, drug delivery, and cell biology. Given the widespread contemporary interest in these topics, time-to-time it urges to review the recent progresses. This review aims to summarize the most recent cutting-edge reports appearing in the last years. It firstly focuses on the application of LDHs as catalysts in relevant chemical reactions and as photocatalysts for organic molecule degradation, water splitting reaction, CO2 conversion, and reduction. Subsequently, the emerging role of these materials in biological applications is discussed, specifically focusing on their use as biosensors, DNA, RNA, and drug delivery, finally elucidating their suitability as contrast agents and for cellular differentiation. Concluding remarks and future prospects deal with future applications of LDHs, encouraging researches in better understanding the fundamental mechanisms involved in catalytic and photocatalytic processes, and the molecular pathways that are activated by the interaction of LDHs with cells in terms of both uptake mechanisms and nanotoxicology effects.

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Advances in Therapeutic Implications of Inorganic Drug Delivery Nano-Platforms for Cancer

Cited by 64 publications

References 104 publications

Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders

Nanoformulations of Herbal Extracts in Treatment of Neurodegenerative Disorders

Convergence of the Study on Monochromatic X-rays and the Research on Nanoparticles Opens Up a Possibility to Develop a New Type of Radiation Therapy

Layered Double Hydroxides: A Toolbox for Chemistry and Biology

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