FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention

Zlatohlávek, L.; Vrablík, M.; Motyková, Eva; Češka, R.; Vasickova, L.; Dlouhá, Dana; Hubacek, Jaroslav A.

doi:10.1016/j.clinbiochem.2012.11.017

Cited by 43 publications

(53 citation statements)

References 20 publications

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“…Interestingly, it has been demonstrated that MTNRB1 is associated with type 2 diabetes mellitus and more recently with gestational diabetes mellitus [18,19]. The effect of the MTNR1B gene on the obesity phenotype is still controversial, but its interactions with other polymorphisms near or within genes involved in body weight loss, such as fat mass and the obesity-associated gene (FTO) , the melanocortin-4 receptor gene (MC4R) and gene-diet interactions, may partly explain the discrepancies [20,21]. …”

Section: Introductionmentioning

confidence: 99%

Gene-Gene Interplay and Gene-Diet Interactions Involving the MTNR1B rs10830963 Variant with Body Weight Loss

et al. 2014

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Background/Aims: Investigation of the genetic makeup may facilitate the implementation of more personalized nutritional interventions. The aims were to examine whether the rs10830963 MTNR1B polymorphism affects weight loss in response to a hypocaloric diet and to find potential gene-gene interplays and gene-diet interactions. Methods: 167 subjects enrolled in a personalized nutritional intervention for weight loss (3-6 weeks) were examined for anthropometric measurements, dietary habits and physical activity at baseline and at the first follow-up visit. Three polymorphisms, which have previously been associated with body weight regulation, rs10830963 (MTNR1B), rs9939609 (FTO) and rs17782313 (MC4R), were analyzed using the Luminex® 100/200™ System. Results: After adjusting for covariates, females with the rs10830963 CG/GG genotype showed lower weight loss than those with the CC genotype. In the total population, carriers of variant alleles of both FTO and MC4R showed a significant association with MTNR1B and weight loss outcome. Moreover, among women, higher total protein and animal protein intakes were associated with a lower weight loss in G allele carriers of the MTNR1B variant. Conclusions: Our data evidenced that rs10830963 MTNR1B polymorphism could be associated with individual differences in weight loss induced by a hypocaloric diet. This association was influenced by FTO and MC4R loci and modified by baseline protein intake.

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Section: Introductionmentioning

confidence: 99%

Gene-Gene Interplay and Gene-Diet Interactions Involving the MTNR1B rs10830963 Variant with Body Weight Loss

et al. 2014

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“…Recent studies addressing the FTO gene and lifestyle and weight loss interventions have offered contradictory results (Moleres et al 2012, Delahanty et al 2012. Certain studies found no relationship between these factors (Delahanty et al 2012, Schum et al 2012, whereas other studies report significant results (Zlatohlavek et al 2013, Reinehr et al 2014). The cause of the different results remains unclear.…”

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confidence: 89%

“…Zlatohlavek et al (2013) investigated two obesity-risk genes (FTO and MC4R rs17817449 rs17782313) in a 4-week intervention study using 357 Czech children (13.7±4.9 years old with an initial BMI of 30.8±4.6 kg/m 2 ). Although these researchers' evaluated polymorphisms different from that evaluated in our study, they observed positive and significant changes in BMI and WC after intervention that suggested a decrease in subjects' fat percentages.…”

Section: Discussionmentioning

confidence: 99%

“…Important genetic changes include changes to the FTO gene, which was first identified in 2007(Jonsson et al 2009). The FTO gene is one of the most recently studied genes (Zlatohlavek et al 2013, Song et al 2014, and its association with obesity has been confirmed in several studies performed using children and adolescents (Liu et al 2010, Foraita et al 2015, Yang et al 2014. FTO rs9939609, which is a single nucleotide polymorphism (SNP), affects body mass index (BMI) in large Caucasian populations (Jonsson et al 2009, González-Sánchez et al 2009).…”

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confidence: 95%

“…Certain individuals do not respond to diet and exercise interventions, suggesting that genetic determinants play a role (Zlatohlavek et al 2013). Recent studies addressing the FTO gene and lifestyle and weight loss interventions have offered contradictory results (Moleres et al 2012, Delahanty et al 2012.…”

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confidence: 99%

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Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention

Moraes

Reuter

Renner

et al. 2016

An. Acad. Bras. Ciênc.

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Background: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention. Methods: The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate aminotransferase, insulin and adiponectin) and blood pressure. The 4-month intervention consisted of physical education classes, nutritional counseling, and postural and oral health counseling. results: We observed no significant differences among the groups (AA, AT and TT) after the intervention. However, we observed improvements in three parameters (waist circumference, hip circumference and C-reactive protein) in the AT/AA genotype group and in two parameters (hip circumference and uric acid) in the TT genotype group. conclusions: After an intervention program, carriers of at-risk genotypes for obesity (AA/AT) do not exhibit differences in biochemical parameters, blood pressure and anthropometric parameters compared with carriers of the TT genotype.

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Obesity Genes and Weight Loss During Lifestyle Intervention in Children With Obesity

et al. 2021

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IMPORTANCE Genome-wide association studies have identified genetic loci influencing obesity risk in children. However, the importance of these loci in the associations with weight reduction through lifestyle interventions has not been investigated in large intervention trials.OBJECTIVE To evaluate the associations between various obesity susceptibility loci and changes in body weight in children during an in-hospital, lifestyle intervention program.DESIGN, SETTING, AND PARTICIPANTS Long-term Effects of Lifestyle Intervention in Obesity and Genetic Influence in Children (LOGIC), an interventional prospective cohort study, enrolled 1429 children with overweight or obesity to participate in an in-hospital lifestyle intervention program. Genotyping of 56 validated obesity single-nucleotide variants (SNVs) was performed, and the associations between the SNVs and body weight reduction during the intervention were evaluated using linear mixed-effects models for each SNV.

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FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention

Cited by 43 publications

References 20 publications

Gene-Gene Interplay and Gene-Diet Interactions Involving the <b><i>MTNR1B </i></b>rs10830963 Variant with Body Weight Loss

Gene-Gene Interplay and Gene-Diet Interactions Involving the <b><i>MTNR1B </i></b>rs10830963 Variant with Body Weight Loss

Genotypic carriers of the obesity-associated FTO polymorphism exhibit different cardiometabolic profiles after an intervention

Obesity Genes and Weight Loss During Lifestyle Intervention in Children With Obesity

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