Background: Children and adolescents with at-risk genotypes (AA/AT) of the rs9939609 polymorphism in FTO, a fat mass and obesity-associated gene, may exhibit different cardiometabolic profile responses than subjects with the TT genotype after an interdisciplinary intervention. Methods: The sample consisted of 36 school children from southern Brazil. We used DNA quantitation and real-time polymerase chain reaction (PCR) for polymorphism genotyping. We measured anthropometric parameters (body mass index (BMI), waist circumference, hip circumference, waist-hip ratio, body fat percentage and skinfold sum), biochemical parameters (glucose, lipid profile, ultra-sensitive C-reactive protein, uric acid, alanine aminotransferase, aspartate aminotransferase, insulin and adiponectin) and blood pressure. The 4-month intervention consisted of physical education classes, nutritional counseling, and postural and oral health counseling. results: We observed no significant differences among the groups (AA, AT and TT) after the intervention. However, we observed improvements in three parameters (waist circumference, hip circumference and C-reactive protein) in the AT/AA genotype group and in two parameters (hip circumference and uric acid) in the TT genotype group. conclusions: After an intervention program, carriers of at-risk genotypes for obesity (AA/AT) do not exhibit differences in biochemical parameters, blood pressure and anthropometric parameters compared with carriers of the TT genotype.
Estudo teve como objetivo analisar a associação do estado nutricional e aptidão cardiorrespiratória (APCR) com a prática de atividade física, indicadores de obesidade familiar, peso ao nascer e histórico de amamentação de escolares. A amostra foi de 1.254 alunos com idades entre sete e 17 anos (54,7% meninas). Foi avaliado o histórico de obesidade familiar, peso ao nascer, amamentação exclusiva por leite materno e prática de atividades físicas. A APCR e o Índice de Massa Corporal (IMC) foram agrupados em uma variável (APCR/IMC), contendo quatro categorias: 1) apto/eutrófico, 2) inapto/eutrófico, 3) apto/excesso de peso e 4) inapto/excesso de peso. Foi utilizada Regressão de Poisson para testar a associação da relação APCR/IMC com a prática de atividade física, o histórico de obesidade familiar, peso ao nascer e amamentação do escolar e análise ajustada incluindo sexo, idade e nível socioeconômico, adotando-se p<0,05. Observou-se elevada proporção de escolares inaptos/obesos (19,7% entre os meninos e 17,6% entre as meninas). A prática de atividade física e a amamentação exclusiva por leite materno até os seis meses apresentam-se como um fator de proteção para inaptidão/eutrofia ou inaptidão/excesso de peso. Já a obesidade do pai e o peso ao nascer do escolar apresentam-se como fatores de risco para inaptidão/excesso de peso. Conclui-se que a presença de inaptidão física e excesso de peso, de forma conjunta, está associada com a não prática de atividades físicas e ausência de amamentação exclusiva por leite materno, e com casos de obesidade do pai e o peso ao nascer elevado do escolar.
http: //dx.doi.org/10.17058/reci.v6i4.8191 Please cite this article in press as: Resultados: Houve predominância do sexo masculino (51,4%), com média de 63,41 anos. Foram identificados 2.087 medicamentos prescritos, com média de 7,9 (± 3,4) medicamentos por prescrição. Das 265 prescrições analisadas, foram encontradas interações medicamentosas em 25,6% e 2,3% de incompatibilidades medicamentosas. Realizaram-se intervenções de trocas de horários em 5,66% e 4,52% de reconciliação medicamentosa. Conclusões: O farmacêutico clínico é de fundamental importância no ambiente hospitalar, visto que o estudo revelou-se uma frequência de 25,66% de interações medicamentosas e 2,26% de incompatibilidades.Realizou-se ainda, intervenções farmacêuticas de trocas de horários de administração de medicamentos em 5,66% das prescrições e em 4,52% de reconciliação medicamentosa, ressaltando assim, que o Serviço de Farmácia Clínica tem grande impacto no aumento da segurança ao paciente e prevenção de eventos adversos. Background and Objectives:The practice of Clinical Pharmacy in hospitals is of utmost importance, as the pharmacist cares for the patient, making it possible the pharmacotherapy optimization, promoting the health and well-being, and preventing diseases and improving the quality of health care. Therefore, the aim of this study was to quantify the occurrence of potential drug interactions, incompatibilities and pharmaceutical interventions carried out on prescriptions of patients treated at an Emergency Care Unit (ECU). Methods: This is a descriptive and quantitative study. The activities were developed in a teaching hospital located in the interior of the state of Rio Grande do Sul from April to July 2016, by resident pharmacists. The study sample consisted of 265 prescriptions of 107 patients. Results: There was a predominance of males (51.4%), with a mean age of 63.41 years. 2,087 prescribed drugs were identified, with a mean of 7.9 (± 3.4) drugs per prescription. Of the 265 analyzed prescriptions, drug interactions were found in 25.6%, as well as 2.3% of drug incompatibilities. RESUMO ABSTRACT
Introduction: Recent studies have shown that the association of FTO rs9939609 gene polymorphism with obesity depends on the level of the individual’s physical activity. However, there are some studies that evaluated physical fitness, health, and motor performance in relation to the rs9939609 FTO gene polymorphism. Objective: To evaluate how the rs9939609 FTO gene polymorphism affects the results of physical fitness tests related to health and athletic performance in schoolchildren after 4 months of intervention of physical exercise. Method: The rs9939609 FTO gene polymorphism was genotyped in a total of 36 schoolchildren from southern Brazil, aged 8 to 16 years. Body mass index (BMI), health-related physical fitness (cardiorespiratory fitness, abdominal strength/endurance, and flexibility) and motor performance (upper and lower limb strength, agility, and speed) were evaluated. The intervention included exercise strategies based on Physical Education, healthy eating, and oral and postural care. Results: In the experimental group, after the intervention, significant differences were noted in individuals with the TT genotype. These individuals showed improvements in abdominal strength (p=0.025), lower limb strength (p=0.037) and agility (p=0.021). For individuals with the AA/AT genotype, improvements in flexibility (p=0.026), abdominal strength (p=0.002), upper limb strength (p=0.008) and lower limb strength (p=0.001) were observed. However, these differences were not statistically significant when comparing the TT and AT/AA genotypes. Conclusions: The experimental group showed improvements in abdominal strength, lower limb strength, and speed. Yet, individuals with different genotypes (AA/AT and TT) for polymorphism rs9939609 exhibited similar values for indicators of physical fitness, health, and motor performance. Level of Evidence II; Lesser quality RCT.
Inga semialata (Vell.) C. Mart. belongs to the family Fabaceae. It is known for its therapeutic properties, highlighting its antimicrobial and antioxidant potential. The objective of the present work was to obtain crude extract leaves of Inga semialata, to identify and quantify active compounds, to evaluate the antioxidant potential of the crude extract in vitro, as well as to determine its antimicrobial activity. The crude extract was obtained by the maceration process. The identified and quantified of compounds present in the crude extract of Inga semialata was performed by high performance liquid chromatography. The evaluation of the antioxidant potential of the
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